Letter to the Editor High altitude pulmonary edema and hypoxia-related genes - Genet. Mol. Res. 14 (3): 11562-11572 “Correlation between single nucleotide polymorphisms in hypoxia-related genes and susceptibility to acute high-altitude pulmonary edema”

Sikri, Gaurav; Dua, Sanchi

doi:10.4238/2015.december.3.3

Cited by 1 publication

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“…The control subjects were defined as HAPE- resistant cohorts due to their resistance to HAPE during exposure to similar high-altitude environment. No subjects reported any history of HAPE or other cardiopulmonary disorders in a questionnaire sheet that contained the components of Lake Louise Score [18]. Blood samples were taken from the study participants, and immediately frozen and stored at −70 C until analysis.…”

Section: Methodsmentioning

confidence: 99%

Angiotensin II receptor 1 gene variants are associated with high-altitude pulmonary edema risk

et al. 2016

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Previous studies demonstrated that Angiotensin II Receptor 1 (AGTR1) may play an important role in the development of high-altitude pulmonary edema. We envisaged a role for AGTR1 gene variants in the pathogenesis of HAPE and investigated their potential associations with HAPE in a Han Chinese population. We genotyped seven AGTR1 polymorphisms in 267 patients with diagnosed HAPE and 304 controls and evaluated their association with risk of HAPE. Statistically significant associations were found for the single nucleotide polymorphisms (SNPs) rs275651 (p = 0.017; odds ratio [OR] = 0.65) and rs275652 (p = 0.016; OR = 0.64). Another SNP rs10941679 showed a marginally significant association after adjusting for age and sex in the additive genetic model (adjusted OR = 1.44, 95% CI = 1.01-2.04, p = 0.040). Haplotype analysis confirmed that the haplotype “AG” was associated with a 35% reduction in the risk of developing HAPE, while the haplotype “AA” increased the risk of developing HAPE by 44%. These results provide the first evidence linking genetic variations in AGTR1 with HAPE risk in Han Chinese individuals.

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Section: Methodsmentioning

confidence: 99%