Letter to the Editor: Is eliminating METTL1‐mediated accumulation of PMN‐MDSCs sufficient to prevent hepatocellular carcinoma recurrence after radiofrequency ablation?

Yang, Fan; Jiang, Shimin; Zheng, Yongchang

doi:10.1002/hep.32638

Cited by 1 publication

(1 citation statement)

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“…Studies in HCC reported similar function of METTL1 in regulating PMN-MDSCs infiltration. The translation of TGF-β2 was upregulated by METTL1-dependent tRNA m7G modification, which could induce the differentiation of peripheral blood mononuclear cells (PBMCs) into PMN-MDSCs and increase their infiltration, thereby suppress the function of CD8 + T cells and promote HCC progression 76 , 113 . Moreover, clustering analysis in HCC demonstrated that the m7G modification level positively correlated with abundance of MDSCs in TIME, and some novel regulators such as NUDT16 and KIF2C were involved in MDSCs regulation 114 , 115 .…”

Section: The Roles Of M7g Modification In Immune Cell Biologymentioning

confidence: 99%

M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets

Han,

Huang,

et al. 2024

Int. J. Biol. Sci.

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RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level. Among these modifications, N7-methylguanosine (m7G) stands out as one of the most prevalent. Over recent years, significant attention has been directed towards understanding the implications of m7G modification. This modification is present in diverse RNA molecules, including transfer RNAs, messenger RNAs, ribosomal RNAs, and other noncoding RNAs. Its regulation occurs through a series of specific methyltransferases and m7G-binding proteins. Notably, m7G modification has been implicated in various diseases, prominently across multiple cancer types. Earlier studies have elucidated the significance of m7G modification in the context of immune biology regulation within the tumor microenvironment. This comprehensive review culminates in a synthesis of findings related to the modulation of immune cells infiltration, encompassing T cells, B cells, and various innate immune cells, all orchestrated by m7G modification. Furthermore, the interplay between m7G modification and its regulatory proteins can profoundly affect the efficacy of diverse adjuvant therapeutics, thereby potentially serving as a pivotal biomarker and therapeutic target for combinatory interventions in diverse cancer types.

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