Letter to the Editor regarding Adams HL, Jaunoo SS. Hyperbilirubinaemia in appendicitis: the diagnostic value for prediction of appendicitis and appendiceal perforation. Eur J Trauma Emerg Surg. 2016; 42:249–52

Scholz, Peter; Lenoir, U.; Borbély, Yves Michael

doi:10.1007/s00068-016-0699-9

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Hyperbilirubinaemia is highly specific with regards to perforation, a finding supported by other studies. However, possibly because of the few perforated cases in this study, we cannot recommend that hyperbilirubinaemia be used to predict perforation [44].…”

Section: International Journal Of Surgery and Orthopedicsmentioning

confidence: 85%

“…A safe alternative seems to be appendectomy as soon as the condition is suspected, a strategy that increases the number of unnecessary appendectomies [4,5]. A timelier and more accurate diagnosis has been attempted by the employment of additional laboratory tests [6][7][8][9][10][11], scoring systems [12-Manuscript Received: 30 th November 2016 Reviewed: 10 th December 2016 Author Corrected: 20 th December 2016 Accepted for Publication: 31 st December 2016 15], ultrasound imaging [16,17], computed tomography (CT) scan [18,19], scintigraphy [20], MRI [21], and laparoscopy [22][23][24]. None of these methods stands alone as they all come in support of, and are secondary to a primary clinical assessment.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of hyperbilirubinaemia as a new diagnostic marker for acute appendicitis & its role in prediction of appendicular perforation

et al. 2016

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Introduction: Acute appendicitis is the most common general surgical emergency and early surgical intervention improves outcomes. The diagnosis of appendicitis can be elusive, and a high index of suspicion is important in preventing serious complications from this disease. The present study was undertaken to assess relationship between hyperbilirubinemia and acute appendicitis to evaluate its credibility as a diagnostic marker for acute appendicitis. Material & methods: The case control study was carried out on 60 patients who were clinically diagnosed as having acute/perforated appendicitis and on 60 healthy volunteers from the community having no signs and symptoms of acute appendicitis. The evaluation of acute appendicitis was done by history taking ,clinical examination and investigations including CBC, Ultrasonography and confirmed by histopathological examination of appendicectomy specimen. For the final analysis various statistical methods like descriptive, crosstabs, chi-square test were applied using the SPSS (version 20.0). Results: Total serum bilirubin level was raised in 43 patients (71.7%) out of the total sample of 60 cases. Of these, 42(70%) cases were positive for appendicitis on HPE (True Positive), and 1(1.7%) was negative on HPE (false positive). Among the 17(28.3%) cases in whom serum bilirubin was not raised, in 3(5%) cases HPE was negative (True Negative), and in 14 (23.3%) cases HPE was positive (False Negative). In 60 healthy individuals mean serum bilirubin was 0.7±0.3 mg%. In 46 cases of histopathologically proved acute appendicitis (non-perforated) the mean serum bilirubin was 1.3±7mg% while in perforated group it was 2.5±1.1mg% (P value was significant i.e. <0.001). Conclusion: Serum bilirubin is an important adjunct in diagnosing the presence of gangrenous/perforated appendicitis. Our findings confirm that hyperbilirubinaemia has a high specificity for distinguishing acute appendicitis.

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Section: International Journal Of Surgery and Orthopedicsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Evaluation of hyperbilirubinaemia as a new diagnostic marker for acute appendicitis & its role in prediction of appendicular perforation

et al. 2016

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“…Life table suggests a risk of 12% for men as well as 25% for the women. 7 The major factor responsible for acute appendicitis is obstruction of the lumen. Fecolith is found in most cases.…”

Section: Discussionmentioning

confidence: 99%

Role of C reactive protein, hyperbilirubinemia and mean platelet volume in diagnosis of acute appendicitis and its correlation post operatively with histo-pathological examination

Mahendra

Agrawal

2023

Int Surg J

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Background: Acute appendicitis is one of the most common abdominal emergencies requiring emergency surgery. The diagnosis based on the onset of symptoms and physical examination. Therefore, inaccuracies caused by subjective interpretation are frequent. This raises the need for tests to help diagnose acute appendicitis and predict the severity of the condition. aim of the study to investigate whether mean platelet volume, C-reactive protein, and hyperbilirubinemia can be used as inflammatory markers for the diagnosis of acute appendicitis and its correlation with histopathological examination. Methods: we prospectively analyzed 60 patients who were full fulling the inclusion criteria patients analysed for CBC, LFT and CRP and underwent for appendicectomy (Laparoscopic/open). Per-operative diagnosis was confirmed by histopathological examination from November 2020 to November 2022. Results: patients with CRP level > 6 and hyperbilirubinemia patients most likely to have acute appendicitis. Mean CRP level was 13.21±4.0 and mean bilirubin level 1.04±0.29 in case of acute appendicitis. CRP, hyperbilirubinemia levels were significantly higher in cases of acute appendicitis (p<0.01) while MPV value was not found significant. All patients was confirmed with histopathology examination. Conclusions: Serum bilirubin level and CRP estimation, which is a simple, cheap, and easily available laboratory test, can be added to the routine investigations in the diagnosis and severity of acute appendicitis and help in decreasing negative appendicectomy rates, especially in low modified Alvarado score.

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Hyperbilirubinemia as a predictive factor in acute appendicitis

Eren

Tombalak

Özemir

et al. 2015

Eur J Trauma Emerg Surg

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Letter to the Editor regarding Adams HL, Jaunoo SS. Hyperbilirubinaemia in appendicitis: the diagnostic value for prediction of appendicitis and appendiceal perforation. Eur J Trauma Emerg Surg. 2016; 42:249–52

Cited by 3 publications

References 4 publications

Evaluation of hyperbilirubinaemia as a new diagnostic marker for acute appendicitis & its role in prediction of appendicular perforation

Evaluation of hyperbilirubinaemia as a new diagnostic marker for acute appendicitis & its role in prediction of appendicular perforation

Role of C reactive protein, hyperbilirubinemia and mean platelet volume in diagnosis of acute appendicitis and its correlation post operatively with histo-pathological examination

Hyperbilirubinemia as a predictive factor in acute appendicitis

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