Leucemia linfoblástica aguda estirpe B Philadelphia negativa en adolescentes y adultos jóvenes: Resultados del Protocolo Terapéutico LLA 15-30, Programa Nacional de Cáncer del Adulto (PANDA), Ministerio de Salud, Chile

Puga, Bárbara; Guerra, Carolina; Molina, Javiera; Cabrera, María Elena; Pilleux, Lilian; Calderón, Susana; Rojas, Christine; Vergara, Carmen; Rojas, Hernán; Munoz, Lina Aguilera; Lois, Vivianne; Aspillaga, Augusto; Pizarro, Álvaro

doi:10.4067/s0034-98872014000600004

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…The main chemotherapy regimens consisted of HyperCVAD and the Chilean young-adult protocol known as "15–30" [4] . In the case of BCR-ABL fusion gene detection, a tyrosine kinase inhibitor was added, and Rituximab was added for CD20-positive marker.…”

Section: Methodsmentioning

confidence: 99%

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Epidemiological and clinical characteristics of adult acute lymphoblastic leukemia patients in Chile: A single-center analysis

Jerez,

Goldschmidt,

Guerra

et al. 2024

Leukemia Research Reports

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Section: Methodsmentioning

confidence: 99%

“…In 2014, results from the national protocol known as “15–30” were reported. This was an adaptation of the Children's Oncology Group AALL0232 protocol [3] , which included 68 patients between the ages of 15 and 32, and reported a 3-year overall survival of 61% [4] . T-lineage patients were not included.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and clinical characteristics of adult acute lymphoblastic leukemia patients in Chile: A single-center analysis

Jerez,

Goldschmidt,

Guerra

et al. 2024

Leukemia Research Reports

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“…En el día decimosegundo tenía paraplejia fláccida, ROT abolidos, sin nivel sensitivo. Un hemograma con recaída leucémica en el día decimo-Tabla 1. protocolo nacional pANDA inducción Quimioterapia intratecal triple (Metotrexato 15 mg, Citarabina 50 mg, Betametasona 4 mg) día 8 y 29 Dexametasona 10 mg/m 2 /día, IV, días 1 al 14 Vincristina 1,5 mg/m 2 /día, IV, (dosis máx 2 mg), días 1,8,15,22 Daunorrubicina 25 mg/m 2 /día, IV, días 1, 8, 15, 22 L-asparaginasa **6.000 U/m 2 ,IM,días 15,17,19,22,24,26 y 29 nono obligó a continuar con cuidados paliativos en su domicilio. El compromiso neurológico no progresó, falleciendo de la LLA.…”

Section: Casounclassified

“…Salvador 364, Providencia, Santiago, Chile. lcartier@med.uchile.cl L a triple asociación de Metrotrexato, Citarabina y Betametazona es un esquema habitual en la quimioterapia intratecal (QI), usada de manera profiláctica, o en el tratamiento de Leucemias Linfoblásticas agudas (LLA) 1 . Esporádicamente, desde la implementación de la QI, se han comunicado casos de mielopatías tóxicas asociadas a este tipo de tratamiento 2 .…”

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Síndrome de degeneración combinada de la médula espinal y radiculopatía en dos pacientes por quimioterapia intratecal con metrotrexato y citarabina. Casos clínicos

et al. 2018

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Intrathecal chemotherapy may be complicated with the development of myelopathies or toxic radiculopathies. This myeloradicular involvement, of toxic character, is unpredictable, since these patients have repeatedly received Intrathecal chemotherapy with the same drugs without apparent injury. The toxic effect should be mainly attributed to Cytarabine and not to methotrexate, since the central nervous system lacks Cytidine deaminase, the enzyme that degrades Cytarabine. We report two patients, an 18-year-old woman and a 16 years old male, who received systemic and intrathecal chemotherapy (methotrexate, cytarabine) for the treatment of an acute lymphoblastic leukemia and developed, in relation to this procedure, a spinal subacute combined degeneration. They had a proprioceptive and motor alteration of the lower extremities and neuroimaging showed selective rear and side spinal cord hyper intensity produced by central axonopathy. Two weeks later the woman developed a quadriplegia and the young man a flaccid paraplegia due to added root involvement.

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Real-world outcomes of treatment for acute lymphoblastic leukemia during adolescence in a financially restricted environment: Results at a single center in Latin America

Jaime‐Pérez

Jiménez-Castillo

Pinzón-Uresti

et al. 2016

Pediatr Blood Cancer

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Objective: There is a paucity of the studies of adolescents with acute lymphoblastic leukemia (ALL). This is more noticeable in low-and middle-income countries. The international 5-year event-free survival (EFS) and overall survival (OS) for this age group is around 80%, with pediatricinspired protocols offering better results. Results:Five-year EFS and OS for 57 adolescents were 23.3% and 48.9%, respectively. From the 41 patients who achieved complete remission, 24 (58.5%) relapsed. Bone marrow and central nervous system were the most frequent sites of relapse. Hazard ratio of treatment failure and death for patients with organomegaly at diagnosis was 2.026 and 2.970, respectively. Treatment-related toxicity developed in 31 (54.4%) patients and febrile neutropenia was the most frequent in 14 (24.6%) cases. Twelve patients (21.1%) had poor adherence to treatment. Conclusions:High relapse rate and low 5-year EFS compared with international standards, was documented. Use of intensified pediatric regimens, adherence to proven effective medications, improved supportive care, and prevention of abandonment are necessary to improve survival rates in these patients.

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Leucemia linfoblástica aguda estirpe B Philadelphia negativa en adolescentes y adultos jóvenes: Resultados del Protocolo Terapéutico LLA 15-30, Programa Nacional de Cáncer del Adulto (PANDA), Ministerio de Salud, Chile

Cited by 5 publications

References 20 publications

Epidemiological and clinical characteristics of adult acute lymphoblastic leukemia patients in Chile: A single-center analysis

Epidemiological and clinical characteristics of adult acute lymphoblastic leukemia patients in Chile: A single-center analysis

Síndrome de degeneración combinada de la médula espinal y radiculopatía en dos pacientes por quimioterapia intratecal con metrotrexato y citarabina. Casos clínicos

Real-world outcomes of treatment for acute lymphoblastic leukemia during adolescence in a financially restricted environment: Results at a single center in Latin America

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