Leucocyte Concentrate from Acidified Plasma

Langfelder, M; Jakschitz, Maria; Ónody, Clara; Zsdánszky, L.

doi:10.1111/j.1423-0410.1972.tb04644.x

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1973

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“…Whether or not antithrombin III, present in our con centrate, is identical to heparin co-factor, the addition of heparin prolonged the recalcification time and proved effective in preventing thrombin develop ment during storage. Storage in the frozen liquid form at -35 °C was ade quate for up to six months; other factor IX concentrates have also been stored satisfactorily in this way [34], However, freeze-drying would be pre ferable for long-term storage.…”

Section: Discussionmentioning

confidence: 99%

Small Scale Preparation and Clinical Use of Factor IX-Prothrombin Complex

Barrowcliffe¹,

Stableforth²,

Dormandy³

1973

Vox Sanguinis

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A procedure is described for the preparation of a concentrate of factors II, VII, IX and X, using a modification of the method of Bruning and Loeliger, involving aluminium hydroxide adsorption of ACD plasma followed by phosphate elution and dialysis. The concentrate produced had an average factor IX activity of 7.4 U/ml with a yield of 61% and a purification of 34.5. Clinical trials in patients with either a congenital deficiency of factor IX or liver disease showed that the concentrate was well tolerated and was an effective haemostatic agent. The average factor IX response was 1.09% for each U/kg injected, giving a recovery of 48%.

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Section: Discussionmentioning

confidence: 99%