Leucocyte count and leucocyte differential in smoking and non-smoking females during pregnancy

Mercelina-Roumans, P.E.A.M.; Ubachs, J.M.H.; Wersch, J. W. J. Van

doi:10.1016/0028-2243(94)90033-7

Cited by 11 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our work, the absolute count and the percentage of neutrophils and monocytes increases throughout pregnancy, which is in agreement with the results of other authors (Nasu et al. , 1992; Mercelina‐Roumans, Ubachs & vanWersch, 1994). However, Kühnert et al.…”

Section: Discussionsupporting

confidence: 94%

See 1 more Smart Citation

Immature granulocyte detection by the SE-9000 haematology analyser during pregnancy

Fernández-Suárez

Pascual

Gimenez

et al. 2003

Clinical &Amp; Laboratory Haematology

View full text Add to dashboard Cite

The objective of this study was to determine the nature of the alarm for immature granulocytes appearing in haemograms from pregnant women, as detected by the immature cell information channel (IMI) of the SE-9000 automated haematology analyser. Of all tests run on pregnant women in a 4-month period (n = 698), the first 100 haemograms with immature granulocyte alarms (14.33%) were collected. Each of these samples was then stained with Wright-Giemsa stain. The following variables were also analysed: age of the mother, trimester and days of gestation, type of delivery, weight and sex of the baby, and Apgar score. Most pregnant women were in the third trimester of gestation (82%) when an alarm was noted on the IMI channel. Of the patients, 62% had normal deliveries. The most frequent complication was obstructed delivery (23%). Mean percentages by microscopic counts of band cells, metamyelocytes, and myelocytes were 2.99, 0.45, and 0.19%, respectively. There was a statistically significant correlation for all cell types between the SE-9000 and the manual count method. No association was observed between the presence of immature granulocytes and the clinical variables analysed. The SE-9000 analyser shows high sensitivity in the IMI channel for detection of immature forms.

show abstract

Section: Discussionsupporting

confidence: 94%

“…In either case, eosinophils are not responsible for the left shift observed during gestation. Mercelina‐Roumans et al. (1994) did not observe variations in the numbers of eosinophils and basophils; however, they did find an increase in lymphocyte numbers both in smoking and nonsmoking pregnant women.…”

Section: Discussionmentioning

confidence: 64%

Immature granulocyte detection by the SE-9000 haematology analyser during pregnancy

Fernández-Suárez

Pascual

Gimenez

et al. 2003

Clinical &Amp; Laboratory Haematology

View full text Add to dashboard Cite

show abstract

“…WBC have been reported to increase throughout gestation in women, despite the hemodilutional effect that occurs (10,40,46 (56) and another has reported no change (12), many others have reported decreases (38,43,49). Decreases in platelet numbers were attributed solely to hemodilution because no evidence of increased platelet turnover (e.g., increased mean platelet volume, reticulated platelets) was observed.…”

Section: Methodsmentioning

confidence: 99%

Changes in Clinical Pathology Parameters During Gestation in the New Zealand White Rabbit

et al. 1999

View full text Add to dashboard Cite

Hematology and serum chemistry parameters were analyzed in 2 groups of pregnant rabbits to assess changes in these parameters over the course of gestation. These data were used to generate a historical control reference range for embryofetal development regulatory toxicology studies. During the 28-day gestation period, the following major changes were observed. Red blood cell counts, hemoglobin, and hematocrit increased slightly up to day 13

show abstract

“…Giant Trophoblasts (Days [14][15][16][17][18][19][20][21]: Necrosis and aggregation of in ammatory cells occurred at different time periods in the various layers. Necrosis of giant trophoblasts surrounding embryofetal tissue started at day 14 at the placental side and included aggregation of in ammatory cells, predominantly neutrophilic granulocytes.…”

Section: In Ammatory Cells and Necrosismentioning

confidence: 99%

Pregnancy Dating in the Rat: Placental Morphology and Maternal Blood Parameters

Rijk¹,

Esch²,

Flik

2002

Toxicol Pathol

106

View full text Add to dashboard Cite

The rat is commonly used as a model in studies on embryology and reproduction toxicology. Surprisingly, the current literature does not provide a comprehensive reference data set on placental development in rat. Therefore, we have evaluated morphological changes of the placenta and maternal blood parameters during pregnancy of the Sprague-Dawley rat. The morphologic data presented in this study may be useful as reference material. This study revealed that placental development in the rat is a well-defined process, characterized by key synchronized morphological events at specific points in time, convenient for laboratory practice and provides the toxicologist with a sensitive tool to distinguish between normal and abnormal placental development and to detect fetal and placental mismatches. During rat pregnancy, significant changes were observed in maternal blood parameters strongly reminiscent of those observed in pregnant women. These changes included: (a) decreased blood cell volume as a result of hemodilution, (b) increased white blood cell counts reflecting the response of the mother to the fetal allograft, (c) increased blood clotting values, (d) decreased plasma glucose and increased lipid content maximizing fetal glucose availability and maternal energy conservation, and (e) decreased electrolyte values reflecting plasma volume expansion. It was concluded that the combined data set on placental morphology and maternal blood parameters in pregnant rats provides powerful tools for recognition of abnormal pregnancies.

show abstract

Leucocyte count and leucocyte differential in smoking and non-smoking females during pregnancy

Cited by 11 publications

References 20 publications

Immature granulocyte detection by the SE-9000 haematology analyser during pregnancy

Immature granulocyte detection by the SE-9000 haematology analyser during pregnancy

Changes in Clinical Pathology Parameters During Gestation in the New Zealand White Rabbit

Pregnancy Dating in the Rat: Placental Morphology and Maternal Blood Parameters

Contact Info

Product

Resources

About