Leucocyte Motion During Gravity Sedimentation of Whole Blood

Bogár, Lajos; Horváth, Júlia; Tekeres, M

doi:10.1007/978-3-642-60735-6_2

Cited by 5 publications

(10 citation statements)

References 8 publications

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“…LAR was determined by measuring leucocyte count in the upper (U) and lower (L) half of the sedimentation tube after one hour of gravity sedimentation. 6 The formula LAR = 100*(U2L)/ (U+L) was used for calculating the percentage of leucocytes crossing the midline of the sedimentation blood column upward during one hour of sedimentation. The inter-assay coefficient of variation for both PCT and LAR measurements was less than 5%.…”

Section: Methodsmentioning

confidence: 99%

“…7 This fall in specific gravity is caused by cell swelling secondary to water uptake occurring during activation of the cells. 7 It has also been shown that a raised LAR is positively correlated with enhanced cellular adherence, 8 increased cell volume, and higher vacuole content of PMNs. 7 LAR can take negative values when the leucocyte count is smaller in the upper blood column than in the lower one after one hour of sedimentation, indicating increased cellular specific gravity relative to the serum.…”

mentioning

confidence: 99%

“…5 We previously reported a simple leucocyte function test measuring the number of upward floating (that is, antisedimenting) leucocytes in a sedimentation tube during one hour of gravity sedimentation. 6 The leucocyte antisedimentation rate (LAR), as a percentage, indicates the proportion of leucocytes crossing the midline of a blood column in an upward direction during one hour of sedimentation. The upward flotation is driven by the ascending plasma and it is further enhanced by a decrease in the specific gravity of polymorphonuclear leucocytes (PMNs) relative to plasma.…”

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confidence: 99%

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Sedimentation characteristics of leucocytes can predict bacteraemia in critical care patients: Figure 1

et al. 2006

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Background: Early detection of blood stream infection can be lifesaving, but the results of blood cultures are not usually available before 24 hours after blood sampling. An earlier indication would lead to the initiation of immediate and adequate antibiotic treatment with obvious advantages for the patient. Objective: To evaluate the ability of leucocyte count, serum procalcitonin (PCT) concentration, erythrocyte sedimentation rate (ESR), and leucocyte antisedimentation rate (LAR) in predicting the blood culture results in critical care patients. Methods: 39 consecutive patients with their first febrile episode were investigated prospectively. LAR was determined as the percentage of leucocytes crossing the midline of a blood column upward during one hour of gravity sedimentation. The relevance of the different variables was estimated by likelihood ratio tests and area under receiver operating characteristic curves (AUC). Results: 23 patients had positive blood culture results and 16 negative. LAR was significantly higher in bacteraemic patients than in non-bacteraemic patients (p = 0.001), but leucocyte count, ESR and PCT level failed to show significant differences. Leucocyte count, PCT, and ESR yielded low discriminative values with the AUCs of 0.66, 0.64, and 0.52, respectively. LAR provided a likelihood ratio of 3.6 and an AUC of 0.80 (95% confidence interval, 0.64 to 0.95) (p = 0.002). Conclusions:The simple LAR test can predict blood culture results and support urgent treatment decisions in critical care patients in their first febrile episode.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Sedimentation characteristics of leucocytes can predict bacteraemia in critical care patients: Figure 1

et al. 2006

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“…LAR was determined as described previously 19 20. In short, Westergren blood sedimentation rate technique was modified for measuring leucocyte motion during gravity sedimentation of the whole blood.…”

Section: Methodsmentioning

confidence: 99%

“…The leucocyte antisedimentation rate (LAR) indicates the percentage of leucocytes crossing the middle line of the blood column upwards during 1 hour of sedimentation 19. It has been shown that a raised LAR is positively correlated with enhanced leucocyte adherence proportional to activation, with an increased cell volume and higher vacuole content of polymorphonuclear leucocytes 20.…”

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confidence: 99%

Deficient leucocyte antisedimentation is related to post-stroke infections and outcome

et al. 2008

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An early activation of leucocytes indicated by an increase of LAR is characteristic of acute ischaemic cerebrovascular events. A delayed and ameliorated leucocyte activation represented by LAR is characteristic of TIA in contrast to stroke. Deficient early activation predisposes to post-stroke infections related to poor outcome. In addition, the extent of tissue injury correlates with the magnitude of innate immune responses.

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Serum procalcitonin level and leukocyte antisedimentation rate as early predictors of respiratory dysfunction after oesophageal tumour resection

et al. 2006

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Leucocyte Motion During Gravity Sedimentation of Whole Blood

Cited by 5 publications

References 8 publications

Sedimentation characteristics of leucocytes can predict bacteraemia in critical care patients: Figure 1

Sedimentation characteristics of leucocytes can predict bacteraemia in critical care patients: Figure 1

Deficient leucocyte antisedimentation is related to post-stroke infections and outcome

Serum procalcitonin level and leukocyte antisedimentation rate as early predictors of respiratory dysfunction after oesophageal tumour resection

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