Leucocyte telomere length as marker for cardiovascular ageing

Zietzer, Andreas; Hillmeister, Philipp

doi:10.1111/apha.12284

Cited by 16 publications

(10 citation statements)

References 68 publications

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“…Telomere length can also be used as a biomarker for replicative senescence (Mather et al 2011;Zietzer & Hillmeister 2014;Bekaert et al 2005.). However, the shortening of telomeres associated with replicative senescence has yet to be translated into a common assay.…”

Section: Dna-related Senescence Biomarkersmentioning

confidence: 99%

Biomarkers to identify and isolate senescent cells

Matjusaitis

Chin

Sarnoski

et al. 2016

Ageing Research Reviews

123

108

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Highlights There is no single biomarker which can robustly identify senescent cells. Widely used senescent cell biomarkers should be used in combination for accuracy. Technologies like tangential flow filtration can be used to isolate senescent cells. Other methods, like senolytic viruses, could be used to remove senescent cells. AbstractAging is the main risk factor for many degenerative diseases and declining health. Senescent To better understand cell aging and to reap the benefits of senescent cell removal, it is necessary to have a reliable biomarker to identify these cells. Following an introduction to cellular senescence, we discuss several classes of biomarkers in the context of their utility in identifying and/or removing senescent cells from tissues. Although senescence can be induced by a variety of stimuli, senescent cells share some characteristics that enable their identification both in vitro and in vivo. Nevertheless, it may prove difficult to identify a single biomarker capable of distinguishing senescence in all cell types. Therefore, this will not be a comprehensive review of all senescence biomarkers but rather an outlook on technologies and markers that are most suitable to identify and isolate senescent cells.

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Section: Dna-related Senescence Biomarkersmentioning

confidence: 99%

Biomarkers to identify and isolate senescent cells

Matjusaitis

Chin

Sarnoski

et al. 2016

Ageing Research Reviews

123

108

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“…Telomeres are repetitive DNA sequences that cap and protect the ends of chromosomes. Some researchers consider telomere length a measure of cellular ageing (Parks et al, 2009;Zietzer & Hillmeister, 2014), as shorter telomeres are associated with poor health (Epel, 2012;Starkweather et al, 2014) and earlier death (Broer et al, 2013;Epel, 2012). For example, studies have found that shorter leukocyte telomere length is associated with an increased risk of cancer and that individuals in the lowest 10% for leukocyte telomere length are 23% more likely to die in the following 3 years than others (Starkweather et al, 2014).…”

mentioning

confidence: 99%

The Relationship Between Perceived Stress and Telomere Length: A Meta‐analysis

Schutte

Malouff

2014

Stress and Health

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Telomeres protect the ends of chromosomes, and short telomere length is associated with poor health and mortality. This study reports a meta-analytic investigation of the relationship between perceived stress and telomere length, including results from eight studies with a total of 1143 participants. A meta-analytic effect size of r = -0.25, p < 0.001, indicated that higher levels of perceived stress were associated with shorter telomere length. Examination of the studies for moderators of effect size identified some significant moderators, such as a difference in effect sizes between samples comprised of only women and mixed-sex samples. These results are only suggestive as they are based on a small set of studies, and funnel plot analyses indicated a publication bias. A significant relationship between more perceived stress and shorter telomere length is consistent with theoretical frameworks positing that stress induces physiological changes that result in shortened telomeres. Copyright © 2014 John Wiley & Sons, Ltd.

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“…Furthermore, PBMC telomere length correlates with that of other tissues and was shown to be an accurate indicator of human vascular ageing and disease processes (Wilson et al . , Zietzer & Hillmeister ). In this context, PMBC telomere length attrition has been established as an independent risk factor for myocardial infarction (Haycock et al .…”

mentioning

confidence: 99%

“…Chronic inflammation and oxidative stress are key processes in atherosclerosis and vascular regeneration and provide a mechanistic link between vascular biology and telomere biology (Aviv 2009). Furthermore, PBMC telomere length correlates with that of other tissues and was shown to be an accurate indicator of human vascular ageing and disease processes (Wilson et al 2008, Zietzer & Hillmeister 2014. In this context, PMBC telomere length attrition has been established as an independent risk factor for myocardial infarction (Haycock et al 2014).…”

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confidence: 99%