Leucoxenols A and B, two new phenolics from Bornean medicinal plant Syzygium leucoxylon

Abstract

The medicinal plant, Syzygium leucoxylon or commonly known as Obah found in North Borneo was considered as traditional medicine by local committee. Two new phenolics, leucoxenols A (1) and B (2) were isolated and identified as major secondary metabolites from the leaves of S. leucoxylon. Their chemical structures were elucidated based on spectroscopic data such as NMR and HRESIMS. Furthermore, these compounds were active against selected strains of fungi.

A New Epi-neoverrucosane-type Diterpenoid from the Liverwort Pleurozia subinflata in Borneo

“…The minimum inhibitory concentration (MIC) of the fungistatic on hyphae was performed by incorporating the pure compound solutions (12.5, 25.0, 50.0, 100.0 μg/mL) onto PYGS agar in a petri dish followed by inoculation of six tested fungal strains [21][22][23]. The MIC was determined visually as the lowest concentration showing no hyphal growth after they were incubated at 25 °C for 7 days.…”

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

“…The most important phenolics identified from pomegranate are punicalin, gallic acid, ellagic acid, pyrogallol, salycillic acid, coumaric acid, vanillic acid, sesamin, and caffeic [ 86 ], and phenolic compounds have been discovered to have inhibitory effects again α-glucosidase activities [ 87 ]. Two new phenolics, leucoxenols A and B, were obtained and identified as major secondary metabolites from the leaves of Syzygium leucoxylon [ 88 ]. Phenolics are main phytochemicals found in Cyathea species, and Cyathea has been considered to be a potential source of novel cancer therapeutic compounds [ 89 ].…”