Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Zhang, Bingjie; Wang, Tao

doi:10.21037/apm-22-665

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…In T-ALL, leukemic infiltration appears in the dermis and the subcutaneous tissue; however, in contrast to primary cutaneous T-cell lymphoma, the epidermis is uninvolved. Leukemic cells typically display T lineage-specific antigens, including CD3, CD4, or CD8, and one or more precursor immature T-cell antigens, including TdT, CD99, CD34, and CD1a [111]. The prognosis of LC in ALL is rather poor.…”

Section: Acute Lymphoblastic Leukemiamentioning

confidence: 99%

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Robak,

Braun,

Robak

2023

Cancers

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Leukemia cutis (LC) is defined as the leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding a number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as the genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, the complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis, and treatment of leukemic skin involvement in different types of leukemia.

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Section: Acute Lymphoblastic Leukemiamentioning

confidence: 99%

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Robak,

Braun,

Robak

2023

Cancers

View full text Add to dashboard Cite

show abstract

“…In T-ALL, leukemic infiltration appears in the dermis and in the subcutaneous tissue; however, in contrast to primary cutaneous T-cell lymphoma, the epidermis is uninvolved. Leukemic cells typically display T lineage-specific antigens including CD3, CD4, or CD8 and one or more precursor immature T-cell antigens including TdT, CD99, CD34, and CD1a [114]. The prognosis of LC in ALL is rather poor.…”

Section: Acute Lymphoblastic Leukemiamentioning

confidence: 99%

Leukemia Cutis—the Current View on Pathogenesis, Diagnosis and Treatment

Robak,

Braun,

Robak

2023

Preprint

View full text Add to dashboard Cite

Leukemia cutis (LC) is defined as leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and in T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis and treatment of leukemic skin involvement in different types of leukemia

show abstract

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Cited by 2 publications

References 11 publications

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Leukemia Cutis—The Current View on Pathogenesis, Diagnosis, and Treatment

Leukemia Cutis—the Current View on Pathogenesis, Diagnosis and Treatment

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