Leukemic transformation in patients with myelodysplastic syndromes after treatment with granulocyte colony-stimulating factor

Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug

“…38,39 In studies of patients with MDS, cytokine therapy has not been associated with an increased risk of progression to AML. 40,41 Eltrombopag increases megakaryocytic proliferation when added to mononuclear cells from patients with AML and MDS but in the majority of samples inhibited blast cell proliferation. 42 Romiplostim, a subcutaneous For personal use only.…”