Leukocyte development, kinetics, and functions

Omman, Reeba; Kini, Ameet R.

doi:10.1016/b978-0-323-53045-3.00018-0

Cited by 7 publications

(13 citation statements)

References 92 publications

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“…Lymphocytes consist of three major groups: T cells, B cells, and NK cells. The major players in adaptive immunity are T and antibody‐producing B cells, which develop in the thymus and bone marrow, respectively, whereas NK cells are part of the innate immunity 123,124 . It is well‐documented that histamine through different receptor subtypes plays an important role in the modulation of lymphocytes during immune responses and inflammatory reactions 5,85,88 (Figure 1).…”

Section: Histamine Modulation Of the Anti‐tumor Immunitymentioning

confidence: 99%

Histamine in cancer immunology and immunotherapy. Current status and new perspectives

Sarasola

Delgado

Nicoud

et al. 2021

Pharmacology Res & Perspec

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Cancer is the second leading cause of death globally and its incidence and mortality are rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells determines the clinical outcome of cancer. Immunotherapy comes to the forefront of cancer treatments, resulting in impressive and durable responses but only in a fraction of patients. Thus, understanding the characteristics and profiles of immune cells in the tumor microenvironment (TME) is a necessary step to move forward in the design of new immunomodulatory strategies that can boost the immune system to fight cancer. Histamine produces a complex and fine‐tuned regulation of the phenotype and functions of the different immune cells, participating in multiple regulatory responses of the innate and adaptive immunity. Considering the important actions of histamine‐producing immune cells in the TME, in this review we first address the most important immunomodulatory roles of histamine and histamine receptors in the context of cancer development and progression. In addition, this review highlights the current progress and foundational developments in the field of cancer immunotherapy in combination with histamine and pharmacological compounds targeting histamine receptors.

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Section: Histamine Modulation Of the Anti‐tumor Immunitymentioning

confidence: 99%

Histamine in cancer immunology and immunotherapy. Current status and new perspectives

Sarasola

Delgado

Nicoud

et al. 2021

Pharmacology Res & Perspec

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“…However, they are also indispensable in humoral immunity via their helper effector functions, such as cytokines release. Whereas B lymphocytes are the major players of humoral immunity and the exclusive source of antibodies ( 12 , 13 ), NK cells are crucial to the innate immune system, which function in a cell-mediated and cytotoxic way that is essential in defending against tumors and viral infections ( 13 ). These three types of lymphocytes help form a sophisticated immune network to recognize and eliminate non-self antigens, thus maintaining the stability of the internal environment in humans.…”

Section: Introductionmentioning

confidence: 99%

The Actin Regulators Involved in the Function and Related Diseases of Lymphocytes

Sun

Zhong

et al. 2022

Front. Immunol.

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Actin is an important cytoskeletal protein involved in signal transduction, cell structure and motility. Actin regulators include actin-monomer-binding proteins, Wiskott-Aldrich syndrome (WAS) family of proteins, nucleation proteins, actin filament polymerases and severing proteins. This group of proteins regulate the dynamic changes in actin assembly/disassembly, thus playing an important role in cell motility, intracellular transport, cell division and other basic cellular activities. Lymphocytes are important components of the human immune system, consisting of T-lymphocytes (T cells), B-lymphocytes (B cells) and natural killer cells (NK cells). Lymphocytes are indispensable for both innate and adaptive immunity and cannot function normally without various actin regulators. In this review, we first briefly introduce the structure and fundamental functions of a variety of well-known and newly discovered actin regulators, then we highlight the role of actin regulators in T cell, B cell and NK cell, and finally provide a landscape of various diseases associated with them. This review provides new directions in exploring actin regulators and promotes more precise and effective treatments for related diseases.

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“…The adaptive immune response of the human body depends on the action of lymphocytes that respond to external antigens, such as viruses, bacteria and fungi. The number of lymphocytes is about 2 × 10 12 and includes the B cells, the T cells and the natural killer (NK) cells [1].…”

Section: Introductionmentioning

confidence: 99%

“…Each B cell has a receptor that is specific for an antigen. Additionally known as hematogones, the immature B cells migrate to secondary lymphatic organs (e.g., spleen, lymph nodes and tonsils), where they bind to an antigen to become memory cells and effector cells [1][2][3]. The memory cells enhance and speed up the response of the immune system if the same foreign antigen enters the body again.…”

Section: Introductionmentioning

confidence: 99%

“…As for B cells, after binding to antigens, T cells turn into memory and effector cells. T cells are about 51-88% of circulating lymphocytes and can be grouped into two categories, according to the presence of CD4 + or CD8 + antigens on their surfaces [1][2][3]. CD4 + T cells can be divided into helper (T h ) and regulatory (T reg ) T cells.…”

Section: Introductionmentioning

confidence: 99%

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Biosensors for Detecting Lymphocytes and Immunoglobulins

et al. 2020

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Lymphocytes (B, T and natural killer cells) and immunoglobulins are essential for the adaptive immune response against external pathogens. Flow cytometry and enzyme-linked immunosorbent (ELISA) kits are the gold standards to detect immunoglobulins, B cells and T cells, whereas the impedance measurement is the most used technique for natural killer cells. For point-of-care, fast and low-cost devices, biosensors could be suitable for the reliable, stable and reproducible detection of immunoglobulins and lymphocytes. In the literature, such biosensors are commonly fabricated using antibodies, aptamers, proteins and nanomaterials, whereas electrochemical, optical and piezoelectric techniques are used for detection. This review describes how these measurement techniques and transducers can be used to fabricate biosensors for detecting lymphocytes and the total content of immunoglobulins. The various methods and configurations are reported, along with the advantages and current limitations.

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Leukocyte development, kinetics, and functions

Cited by 7 publications

References 92 publications

Histamine in cancer immunology and immunotherapy. Current status and new perspectives

Histamine in cancer immunology and immunotherapy. Current status and new perspectives

The Actin Regulators Involved in the Function and Related Diseases of Lymphocytes

Biosensors for Detecting Lymphocytes and Immunoglobulins

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