Leukocyte integrin activation mediates transient neutropenia after G-CSF administration

G-CSF maintains controlled neutrophil mobilization during acute inflammation by negatively regulating CXCR2 signaling

“…Although G-CSF has been routinely used to treat neutropenia, transient neutropenia often occurs shortly after G-CSF administration. A recent study suggests that this transient neutropenia is mainly caused by neutrophil accumulation in pulmonary vasculature ( DeJesus et al, 2011 ) and might be mediated by leukocyte integrin activation after G-CSF administration ( Donahue et al, 2011 ). Our results indicate that G-CSF–induced inhibition of CXCR2 signaling may be an alternative mechanism leading to G-CSF–elicited transient neutropenia.…”

Oxandrolone for the treatment of bone marrow failure in Fanconi anemia

“…Oxandrolone appears to be well-tolerated, has limited toxicities at the administered doses in FA with patients, and may be an alternative androgen for the treatment of BMF in FA. Pediatr Blood Cancer 2014;61: [11][12][13][14][15][16][17][18][19]. # 2013 Wiley Periodicals, Inc.…”

“…Also alternative therapies may be employed in event of infection or organ complications requiring treatment or which obviate a safe HCT. Alternative therapies might include growth factors such as granulocyte colony stimulating factor for profound neutropenia, although hemoglobin and platelet counts may continue to decline . Another alternate therapy used for BMF in FA is androgen therapy.…”

Assessment of CD11b and CD11/18 integrin expression on leukocytes of dogs with atopic dermatitis

“…β2 integrins (CD18), which are present on leukocyte membranes bind to the ICAM group and are responsible for adhesion of leukocytes to the endothelium during inflammation. They combine with αL, αM, and αX integrin subunits to form CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1, CR3), and CD11c/ CD18 (gp150/95, CR4), respectively (1,3,10,15). The CD11a/18 integrin mainly occurs on lymphocytes and is responsible for adhesion of T cells to antigen-presenting cells and of leukocytes to endothelial cells.…”