Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women

Kim, Moo-Young; Lee, Jiwon; Kang, Hee Cheol; Kim, Eosu; Lee, Duk Chul

doi:10.1016/j.archger.2010.11.019

Cited by 77 publications

(53 citation statements)

References 27 publications

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“…Regarding mtDNA in peripheral cells, Kim et al (2011) found decreased mtDNA content in leukocytes of patients with depression. Their study, however, did not use any diagnostic tool.…”

Section: Discussionmentioning

confidence: 96%

“…Their study, however, did not use any diagnostic tool. Moreover, Kim et al (2011) evaluated elderly patients with depressive symptoms while our sample comprised young adults with bipolar depression. Our study used standard tools for diagnosis and symptom evaluation, enhancing the validity of the findings.…”

Section: Discussionmentioning

confidence: 99%

“…In BD, only one post-mortem study found subtle changes in mtDNA (Vawter et al, 2006), while others found no differences compared to controls Sabunciyan et al, 2007;Torrell et al, 2013). Importantly, a study of elderly patients showed decreased mtDNA content associated with depressive symptoms (Kim et al, 2011). Lithium is a gold standard treatment for mood episodes and maintenance in BD (Machado-Vieira et al, 2009).…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Leukocyte mitochondrial DNA copy number in bipolar disorder

Sousa

Uno

Zanetti

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Regarding mtDNA in peripheral cells, Kim et al (2011) found decreased mtDNA content in leukocytes of patients with depression. Their study, however, did not use any diagnostic tool.…”

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Leukocyte mitochondrial DNA copy number in bipolar disorder

Sousa

Uno

Zanetti

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…mtDNA copy number has been reported to be high in autism (25), and reduced in a recent study of bipolar disorder (26) but not others (27–31). A few studies have assessed mtDNA copy number in patients with MDD: no difference was found between MDD patients and controls in a small post-mortem study of brain tissue (31) or in a large study in outpatients with MDD and matched controls (32), but there is some evidence of reduced leukocyte mtDNA copy number in association with depression in women over age 60 (33). We are not aware of any investigations of mtDNA copy number in relation to anxiety disorders, alcohol or substance disorder, or psychosocial stress exposure.…”

Section: Introductionmentioning

confidence: 99%

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Tyrka

Parade

Price

et al. 2016

Biological Psychiatry

234

177

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Background Telomere shortening and alterations of mitochondrial biogenesis are involved in cellular aging. Childhood adversity is associated with telomere shortening, and several investigations have shown short telomeres in psychiatric disorders. Recent studies have examined whether mitochondria might be involved in neuropsychiatric conditions; findings are limited and no prior work has examined this in relation to stress exposure. Methods Two-hundred and ninety healthy adults provided information on childhood parental loss and maltreatment and completed diagnostic interviews. Participants were categorized into four groups based upon the presence or absence of childhood adversity and the presence or absence of lifetime psychopathology (depressive, anxiety, and substance use disorders). Telomere length and mtDNA copy number were measured from leukocyte DNA by qPCR. Results Childhood adversity and lifetime psychopathology were each associated with shorter telomeres (p < .01) and higher mtDNA copy numbers (p < .001). Significantly higher mtDNA copy numbers and shorter telomeres were seen in individuals with major depression, depressive disorders, and anxiety disorders, as well as those with parental loss and childhood maltreatment. A history of substance disorders was also associated with significantly higher mtDNA copy numbers. Conclusion This study provides the first evidence of an alteration of mitochondrial biogenesis with early life stress and with anxiety and substance use disorders. We replicate prior work on telomere length and psychopathology, and show that this effect is not secondary to medication use or comorbid medical illness. Finally, we show that early life stress and psychopathology are each associated with these markers of cellular aging.

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“…Reduced mtDNAcn has been reported in post-traumatic stress disorder 47 and in relation to depressive symptoms among elderly communitydwelling women without MDD. 48,49 Higher leukocyte mtDNA-cn has been reported in autism 50 and lifetime psychopathology in healthy people. 51 MtDNA-cn has been found to be lower 52 and unchanged 53 in bipolar disorder.…”

Section: Discussionmentioning

confidence: 99%

Stress: A deadly weapon

Peñagarikano

2016

Sci. Transl. Med.

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Preclinical data suggest that chronic stress may cause cellular damage and mitochondrial dysfunction, potentially leading to the release of mitochondrial DNA (mtDNA) into the bloodstream. Major depressive disorder has been associated with an increased amount of mtDNA in leukocytes from saliva samples and blood; however, no previous studies have measured plasma levels of free-circulating mtDNA in a clinical psychiatric sample. In this study, free circulating mtDNA was quantified in plasma samples from 37 suicide attempters, who had undergone a dexamethasone suppression test (DST), and 37 healthy controls. We hypothesized that free circulating mtDNA would be elevated in the suicide attempters and would be associated with hypothalamic-pituitaryadrenal (HPA)-axis hyperactivity. Suicide attempters had significantly higher plasma levels of free-circulating mtDNA compared with healthy controls at different time points (pre-and post-DST; all P-values o2.98E − 12, Cohen's d ranging from 2.55 to 4.01). Pre-DST plasma levels of mtDNA were positively correlated with post-DST cortisol levels (rho = 0.49, P o 0.003). Suicide attempters may have elevated plasma levels of free-circulating mtDNA, which are related to impaired HPA-axis negative feedback. This peripheral index is consistent with an increased cellular or mitochondrial damage. The specific cells and tissues contributing to plasma levels of free-circulating mtDNA are not known, as is the specificity of this finding for suicide attempters. Future studies are needed in order to better understand the relevance of increased free-circulating mtDNA in relation to the pathophysiology underlying suicidal behavior and depression.

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Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women

Cited by 77 publications

References 27 publications

Leukocyte mitochondrial DNA copy number in bipolar disorder

Leukocyte mitochondrial DNA copy number in bipolar disorder

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Stress: A deadly weapon

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