Leukocyte proliferation in vitro against cottontail rabbit papillomavirus in rabbits with persisting papillomas/cancer or after regression

Höpfl, Reinhard; hristensen, N D; Angell, Michael G.; Kreider, John W.

doi:10.1007/bf00371738

Cited by 9 publications

(5 citation statements)

References 28 publications

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“…Other HPV proteins such as E1, E2 and L1 are also capable to elicit lymphocyte proliferation (59,60). In animal models, a positive lymphoproliferative response to cottontail rabbit papillomavirus L1 and L2 protein was detected in animals with regressing papilloma (61).…”

Section: Immunological Response Against Hpvmentioning

confidence: 89%

Genetic susceptibility to HPV infection and cervical cancer

Maciag¹,

Villa²

1999

Braz J Med Biol Res

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Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation.

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Section: Immunological Response Against Hpvmentioning

confidence: 89%

Genetic susceptibility to HPV infection and cervical cancer

Maciag¹,

Villa²

1999

Braz J Med Biol Res

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“…Immune cell infiltration is correlated with CRPV-induced tumor regression, as demonstrated in other PV models and HPV [41,[103][104][105][106][107][108]. The changes at the transcription level of the host genes that were identified and correlated with CRPV infection have been reported [82,90,112,113], including common signal transduction pathways/ molecules in HPV specimens.…”

Section: Host Changes During Viral Infectionmentioning

confidence: 78%

“…The contribution of the host immune control of papillomavirus infections has benefited from studies on tumors that regressed [97][98][99]. Tumor regression correlated with infiltration of the CD4 and CD8 T cells that target early genes, such as E2 and E6 [100][101][102][103][104][105][106][107][108]. The CRPV model will be a useful tool to gain deeper understanding of the roles of infiltrating cells in the regression, using novel technology such as single-cell omics.…”

Section: Early Gene E6 Is Important For Tumor Regressionmentioning

confidence: 99%

Modeling HPV-Associated Disease and Cancer Using the Cottontail Rabbit Papillomavirus

Cladel

Peng

et al. 2022

Viruses

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Approximately 5% of all human cancers are attributable to human papillomavirus (HPV) infections. HPV-associated diseases and cancers remain a substantial public health and economic burden worldwide despite the availability of prophylactic HPV vaccines. Current diagnosis and treatments for HPV-associated diseases and cancers are predominantly based on cell/tissue morphological examination and/or testing for the presence of high-risk HPV types. There is a lack of robust targets/markers to improve the accuracy of diagnosis and treatments. Several naturally occurring animal papillomavirus models have been established as surrogates to study HPV pathogenesis. Among them, the Cottontail rabbit papillomavirus (CRPV) model has become known as the gold standard. This model has played a pivotal role in the successful development of vaccines now available to prevent HPV infections. Over the past eighty years, the CRPV model has been widely applied to study HPV carcinogenesis. Taking advantage of a large panel of functional mutant CRPV genomes with distinct, reproducible, and predictable phenotypes, we have gained a deeper understanding of viral–host interaction during tumor progression. In recent years, the application of genome-wide RNA-seq analysis to the CRPV model has allowed us to learn and validate changes that parallel those reported in HPV-associated cancers. In addition, we have established a selection of gene-modified rabbit lines to facilitate mechanistic studies and the development of novel therapeutic strategies. In the current review, we summarize some significant findings that have advanced our understanding of HPV pathogenesis and highlight the implication of the development of novel gene-modified rabbits to future mechanistic studies.

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“…The lymphoproliferative assays were positive in animals with regressing warts, whereas in progressors the reactivity to CRPV was decreased. 164 Lymphoproliferative responses to oncoproteins of genital HPV16 have disclosed that E7 could serve as a tumor rejection antigen. 165 This assay may be of some value for monitoring specific cellular immunity in anogenital infec-tions and genital cancer.…”

Section: Clinically Applicable Assays For the Assessment Of Anti-hpv mentioning

confidence: 99%