Leukocytes in peripheral blood in patients with bipolar disorder – Trait and state alterations and association with levels of cytokines and C-reactive protein

Munkholm, Klaus; Jacoby, Anne Sophie; Lenskjold, Toke; Bruunsgaard, Helle; Vinberg, Maj; Kessing, Lars Vedel

doi:10.1016/j.psychres.2018.01.022

Cited by 16 publications

(11 citation statements)

References 32 publications

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“…However, less is known on the role of MPO in individuals without symptomatic CVD, but epidemiologic studies demonstrate that MPO may predict future risk of coronary artery disease ( 50 ). Furthermore, elevated neutrophil counts have been reported in BD and SCZ ( 51 – 53 ) and based on the increased MPO levels observed in our study, it is tempting to speculate that abnormalities in neutrophil activation could represent an early event in the progression of CVD in patients with psychotic disorders. The stronger association with the TC/HDL compared to the TG/HDL, could suggest that the enhanced MPO is more directly linked to atherogenesis and not only a marker of this process.…”

Section: Discussionsupporting

confidence: 57%

Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders

et al. 2020

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Results: A markedly higher proportion (26%-31%) of patients had increased TC/HDL and TG/HDL ratios compared with HC. Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO) were higher (p<0.05, p<0.001) in patients with psychotic disorders than in HC, and hs-CRP and MPO were independently associated with atherogenic lipid ratios in the multivariable analyses. Conclusions: Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development of novel risk evaluation strategies.

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Section: Discussionsupporting

confidence: 57%

Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders

et al. 2020

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“…Recent evidence has also suggested that the levels of specific inflammatory cytokines are associated with cognitive function (Barbosa et al, 2012;Hope et al, 2015) and neuroanatomical alterations (Magioncalda et al, 2018) in patients. Moreover, further peripheral findings in BD have suggested altered proportions of monocytes and lymphocytes subsets in blood from BD patients compared to controls (Barbosa et al, 2014c;Munkholm et al, 2018).…”

Section: Peripheral Inflammatory Markers In Bdmentioning

confidence: 98%

Revisiting inflammation in bipolar disorder

Fries

Walss‐Bass

Bauer

et al. 2019

Pharmacology Biochemistry and Behavior

121

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“…Peripheral inflammation markers are frequently reported in MDD [5,6] and BD. [7–9] Cytokines are cell signal transducing proteins or polypeptides that mediate and regulate immune responses and inflammation. Cytokines have been shown to cross the blood-brain barrier, [10] thereby influencing many aspects of mood disorder pathophysiology, including neurotransmitter metabolism, neuroendocrine function, neural plasticity, [11] and subsequently altering the activation of the brain and affecting emotion and behavior.…”

Section: Introductionmentioning

confidence: 99%

High concentrations of serum interleukin-6 and interleukin-8 in patients with bipolar disorder

Rao

Mou

et al. 2019

Medicine

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Immune system dysregulation plays a key role in the physiopathology of bipolar disorder (BD) and major depressive disorder (MDD). However, whether interleukins might be biomarkers to distinguish these 2 affective disorders is unclear. Here, we assessed the differences in serum levels of interleukin 6 (IL-6) and interleukin 8 (IL-8) as well as C-reactive protein (CRP) in patients with MDD and BD. In total, we enrolled 21 MDD patients, 26 BD patients, and 20 healthy controls. We collected a total of 35 samples from BD patients in 3 different phases, depression phase, manic phase, and remission stage, and 27 samples from MDD patients in acute and remission phases. Serum IL-6 and IL-8 levels were assessed with solid phase sandwich ELISA-based quantitative arrays, and CRP levels were determined with an automatic analyzer. Both serum IL-6 and IL-8 levels were elevated in BD patients but not MDD patients. Subgroup analysis indicated elevated serum IL-6 in both the depression and manic phases in BD patients. The serum CRP levels did not change in either BD or MDD patients. However, sex differences in CRP concentrations were observed in healthy controls. Furthermore, there were linear correlations between the CRP levels and Bech-Rafaelsen Mania Rating Scale (BRMS) scores in BD patients. IL-6 and IL-8 levels may serve as biomarkers to differentiate between MDD and BD patients, even when the clinical manifestations are atypical. IL-6 may be used for the differential diagnosis of MDD and depressive episodes in BD.

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Leukocytes in peripheral blood in patients with bipolar disorder – Trait and state alterations and association with levels of cytokines and C-reactive protein

Cited by 16 publications

References 32 publications

Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders

Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders

Revisiting inflammation in bipolar disorder

High concentrations of serum interleukin-6 and interleukin-8 in patients with bipolar disorder

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