Leukotriene C4 generation from human eosinophils stimulated with IgG-Aspergillus fumigatus antigen immune complexes

Cromwell, Oliver; Moqbel, Redwan; Fitzharris, Penny; Kurlak, Lesia O.; Harvey, C; Walsh, Garry Michael; Shaw, R.J.; Kay, A. B.

doi:10.1016/0091-6749(88)90962-1

Cited by 20 publications

(4 citation statements)

References 24 publications

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“…In ABPA, significant amounts of Aspergillus-specific IgA antibodies are produced within BALT and are present within the bronchial mucus. Thus, both IgE and IgA anti-Aspergillus antibodies bound to their Fc receptors on eosinophils trigger mediator release when they engage allergen [142,171]. When eosinophil-bound IgE, IgA, and IgG are cross-linked by Aspergillus antigens, the eosinophils are triggered to secrete inflammatory mediators, such as major basic protein and eosinophil-derived neurotoxin [142].…”

Section: Immunopathogenesis Of Abpa In Cfmentioning

confidence: 98%

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

et al. 2003

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Because of the difficulties of recognizing allergic bronchopulmonary aspergillosis (ABPA) in the context of cystic fibrosis (because of overlapping clinical, radiographic, microbiologic, and immunologic features), advances in our understanding of the pathogenesis of allergic aspergillosis, new possibilities in therapy, and the need for agreed-upon definitions, an international consensus conference was convened. Areas addressed included fungal biology, immunopathogenesis, insights from animal models, diagnostic criteria, epidemiology, the use of new immunologic and genetic techniques in diagnosis, imaging modalities, pharmacology, and treatment approaches. Evidence from the existing literature was graded, and the consensus views were synthesized into this document and recirculated for affirmation. Virulence factors in Aspergillus that could aggravate these diseases, and particularly immunogenetic factors that could predispose persons to ABPA, were identified. New information has come from transgenic animals and recombinant fungal and host molecules. Diagnostic criteria that could provide a framework for monitoring were adopted, and helpful imaging features were identified. New possibilities in therapy produced plans for managing diverse clinical presentations.

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Section: Immunopathogenesis Of Abpa In Cfmentioning

confidence: 98%

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

et al. 2003

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“…CD32 (FcγRII) is constitutively expressed on resting human eosinophils (Hartnell et al 1990), and is upregulated by IFN‐γ (Hartnell et al 1992). These receptors not only function as IgG receptors but also appear to have a role in stimulating eosinophil survival, degranulation, and generation of leukotrienes (Cromwell et al 1988, 1990; Kita et al 1991; Kim et al 1999). Eosinophils do not constitutively express FcγRI (CD64) or low‐affinity FcγRIII (CD16), although expression can be upregulated by cytokines, IFN‐γ, complement (C5a), and PAF (Hartnell et al 1992).…”

Section: Eosinophil Surface Markersmentioning

confidence: 99%

Eosinophils: Biological Properties and Role in Health and Disease

Hogan¹,

Rosenberg²,

Moqbel³

et al. 2008

Clin Experimental Allergy

715

430

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SUMMARYEosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of diverse inflammatory responses, as well as modulators of innate and adaptive immunity. In this review, the biology of eosinophils is summarized, focusing on transcriptional regulation of eosinophil differentiation, characterization of the growing properties of eosinophil granule proteins, surface proteins and pleiotropic mediators, and molecular mechanisms of eosinophil degranulation. New views on the role of eosinophils in homeostatic function are examined, including developmental biology and innate and adaptive immunity (as well as their interaction with mast cells and T cells) and their proposed role in disease processes including infections, asthma, and gastrointestinal disorders. Finally, strategies for targeted therapeutic intervention in eosinophil-mediated mucosal diseases are conceptualized.

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“…Furthermore, there have been several functional studies that have involved the interaction of eosinophils witb IgG-coated particles. For example, eosinophils kill helminthic targets opsonized with specilic IgG antibody [47]; release granule-associated basic proteins after IgG-mediated activation [48] and generate leukotriene C4 [4,49] and secrete granule-associated cationic proteins [50] when incubated with IgG-coated Sepharose beads. Various studies have identified differences in the functional responsiveness of low-and normal-density eosinophils, including the fact tbat low-density eosinophils generate significantly more of the lipid mediator leukotriene C4 when stimulated with IgG-coated beads [4], serum-treated zymosan [51] or calcium ionophore A23187 [52] than do normal-density cells from the same patients.…”

Section: Paf Generation By Eosinophilsmentioning

confidence: 99%

Biological properties of eosinophils

Kay¹

1991

Clin Experimental Allergy

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Leukotriene C4 generation from human eosinophils stimulated with IgG-Aspergillus fumigatus antigen immune complexes

Cited by 20 publications

References 24 publications

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

Eosinophils: Biological Properties and Role in Health and Disease

Biological properties of eosinophils

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