Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

Samuelsson, Bengt; Dahlén, Sven‐Erik; Lindgren, Jan; Rouzer, Carol A.; Serhan, Charles N.

doi:10.1126/science.2820055

Cited by 2,161 publications

(1,307 citation statements)

References 50 publications

Supporting

Mentioning

1,270

Contrasting

Unclassified

Order By: Relevance

“…In addition, we detected 5-LO expression in renal tissue that also exhibited positive staining for viral antigens in serial sections; 5-LO is an essential enzyme for the biosynthesis of leukotrienes, which are potent proinflammatory mediators (15). Recently, we demonstrated that HCMV induces 5-LO expression in vitro and in patients with inflammatory bowel disease (16).…”

Section: Discussionmentioning

confidence: 85%

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection

Varani¹,

Mastroianni²,

Frascaroli³

et al. 2009

Arthritis & Rheumatism

View full text Add to dashboard Cite

Human cytomegalovirus (HCMV) is frequently detected in autoimmune diseases, but its role in such disorders is poorly understood. Herein we describe the case of a young woman who developed generalized Wegener's granulomatosis (WG) after HCMV mononucleosis and urinary tract infection. During mononucleosis, the patient had extraordinarily high plasma levels of proinflammatory cytokines such as interleukin-5 and lymphotoxin ␣, autoantibodies, and a higher blood level of viral DNA than were found in other immunocompetent patients infected with HCMV or healthy controls. Active HCMV replication was detected after the onset of vasculitis, and HCMV genomes or antigens were found in blood, urine, and inflammatory lesions on the kidney. Thus, HCMV may have triggered or exacerbated inflammation and autoimmunity in this case of WG.

show abstract

Section: Discussionmentioning

confidence: 85%

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection

Varani¹,

Mastroianni²,

Frascaroli³

et al. 2009

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Both NO [2,20] and lipoxygenase products such as leukotrienes and hydroxy fatty acids [21][22][23] are messenger molecules which exhibit a variety of biologically relevant properties. So far no direct interaction of both pathways in mammalian cells has been described.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre‐activated ferric species

et al. 1996

View full text Add to dashboard Cite

Nitric oxide is known as an inhibitor of soybean lipoxygenase-1. Investigating the interaction of a mammalian 15-lipoxygenase with nitric oxide, we found that this enzyme is also inhibited reversibly when incubated with nitric oxide for a short time period (5 s) under anaerobic conditions. This inhibition may be due to the formation of a dissociable lipoxygenase-nitric oxide complex. With longer incubation periods the ferrous lipoxygenase is oxidised to a ferric form. This oxidation renders the enzyme more susceptible to peroxide activation, causing a timedependent shortening of the kinetic lag phase.

show abstract

“…Chiral purity of biologically derived hydroxylated fatty acids is typically attributed to the lipoxygenase (Lox) family [24][25][26][27][28][29][30][31] with preference usually shown for S-stereoisomer products. In the absence of Lox, however, free-radical mediated peroxidation of AA can yield a racemic mixture of each hydroxylated isomer.…”

Section: Resultsmentioning

confidence: 99%

Identification of hydroxyeicosatetraenoic acid components of schistosomal hemozoin

Carter

Harry

Wright

2007

Biochemical and Biophysical Research Communications

View full text Add to dashboard Cite

During the late stages of Schistosoma mansoni infection, adult schistosomes catabolize host erythrocytic hemoglobin. In order to evade the toxic effects of free heme, the blood fluke biomineralizes dimeric heme into an inert crystalline pigment called hemozoin. In the present study, the chemical reactivity of schistosomal hemozoin (SmHz) toward lipid oxidation was examined and the biological consequences of reactivity were investigated. Mass spectrometric analysis of polar lipid content associated with SmHz identified a variety of primary and secondary polyunsaturated fatty acid oxidation products, including hydroxyeicosatetraenoic acids. Furthermore, RAW 264.7 macrophage-like cells challenged with lipopolysaccharide prior to phagocytosis of SmHz experienced a decrease in nitric oxide production as compared to control experiments. The presence of these biologically active oxidation products suggests native SmHz is capable of modulating the innate immune response and may play a potential role in the pathogenesis of schistosomiasis.

show abstract

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

Cited by 2,161 publications

References 50 publications

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection

Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection

Nitric oxide oxidises a ferrous mammalian lipoxygenase to a pre‐activated ferric species

Identification of hydroxyeicosatetraenoic acid components of schistosomal hemozoin

Contact Info

Product

Resources

About