Level of urinary catecholamine in children with Sleep Disordered Breathing: A systematic review and meta-analysis

Cheng, Esther T.W.; Chan, Raymond N.C.; Chan, KateC.C.; Au, Chun Ting; Li, Albert Martin

doi:10.1016/j.sleep.2022.10.008

Cited by 11 publications

(6 citation statements)

References 44 publications

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“…8 Furthermore, a recent meta-analysis reported that urinary noradrenaline levels were higher in children with SDB, suggesting sympathetic overactivity in such children. 13 Further analysis of our data showed that the alerting network efficiency did not change linearly with disease severity; in fact, it was highest in mild OSA cases and was not correlated with the OAHI. This disparity between cognitive function and disease severity was reported in previous study.…”

Section: Discussionmentioning

confidence: 65%

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Characteristics of the Attentional Network in Children with Sleep-Disordered Breathing

Wu,

Wang,

Wang

et al. 2023

NSS

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To explore the characteristics of the attentional network and related factors in children with sleep-disordered breathing (SDB). Patients and Methods: A total 228 children (200 children aged 6-10 years with snoring or mouth breathing, admitted to our hospital from May 2020 to July 2022, and 28 healthy children recruited from the community as the control group) were enrolled. All participants underwent polysomnography (PSG) and completed the ADHD rating scale and child version of the Attention Network Test. According to their SDB history and obstructive apnea hypopnea index (OAHI), the participants were divided into control (n = 28), primary snoring (PS; n = 67) and obstructive sleep apnea (OSA; n = 133) groups. Results:The OSA and PS groups were younger than controls (P < 0.05). The proportion of boys was higher in the OSA than control group (P < 0.05). Body mass index was higher in the OSA than control and PS groups (P < 0.01). Attention deficit and hyperactive impulsivity scores were independently associated with the OAHI (P < 0.001). The efficiency of the alerting network was higher in the OSA than in controls (P = 0.020), but was not correlated with OAHI after adjusting for age, sex and SDB history duration (P > 0.05). Conclusion:Children with OSA have impaired attention, characterized by excessive alerting network activation. However, alerting network efficiency did not change linearly with disease severity. More research is needed to elucidate the neural mechanisms underlying attention deficits in pediatric OSA.

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Section: Discussionmentioning

confidence: 65%

“… 8 Furthermore, a recent meta-analysis reported that urinary noradrenaline levels were higher in children with SDB, suggesting sympathetic overactivity in such children. 13 …”

Section: Discussionmentioning

confidence: 99%

Characteristics of the Attentional Network in Children with Sleep-Disordered Breathing

Wu,

Wang,

Wang

et al. 2023

NSS

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“…The acknowledgment of the role of inflammatory diseases in this context highlights the need for a holistic approach in both diagnosis and management. Furthermore, the interwoven nature of tobacco habit, obstructive pulmonary disease, obstructive sleep apnea syndrome, obesity, diabetes mellitus, dyslipidemia, and inflammatory diseases is exemplified by their shared characteristic of fostering an increased systemic inflammatory state [1,2,[4][5][6][7][9][10][11][12][13].…”

Section: Inflammation and Atrial Fibrillationmentioning

confidence: 99%

“…Obstructive sleep apnea syndrome favors the increased secretion of catecholaminergic hormones that tend to increase systemic blood pressure values and promote systemic inflammation, thus leading to a dual risk [4,5].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Disease from Pathophysiology to Risk Estimation: Is Inflammation Estimated through Perivascular Attenuation on Computed Tomography the Key?

Tuttolomondo,

Niccoli,

Martini

et al. 2024

Life

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(1) Background: Systemic inflammation stands as a well-established risk factor for ischemic cardiovascular disease, as well as a contributing factor in the development of cardiac arrhythmias, notably atrial fibrillation. Furthermore, scientific studies have brought to light the pivotal role of localized vascular inflammation in the initiation, progression, and destabilization of coronary atherosclerotic disease. (2) Methods: We comprehensively review recent, yet robust, scientific evidence elucidating the use of perivascular adipose tissue attenuation measurement on computed tomography applied to key anatomical sites. Specifically, the investigation extends to the internal carotid artery, aorta, left atrium, and coronary arteries. (3) Conclusions: The examination of perivascular adipose tissue attenuation emerges as a non-invasive and indirect means of estimating localized perivascular inflammation. This measure is quantified in Hounsfield units, indicative of the inflammatory response elicited by dense adipose tissue near the vessel or the atrium. Particularly noteworthy is its potential utility in assessing inflammatory processes within the coronary arteries, evaluating coronary microvascular dysfunction, appraising conditions within the aorta and carotid arteries, and discerning inflammatory states within the atria, especially in patients with atrial fibrillation. The widespread applicability of perivascular adipose tissue attenuation measurement underscores its significance as a diagnostic tool with considerable potential for enhancing our understanding and management of cardiovascular diseases.

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“…Urinary noradrenaline increased in all patients with SDB; instead, subjects with OSA had higher urine levels of noradrenaline and adrenaline. The urinary noradrenaline level is higher in severe OSAS, confirming the autonomic imbalance in children affected by OSA; the authors proposed the possible use of these biomarkers to screen children at risk for SDB and predict the severity also [ 84 ].…”

Section: What Is the Role Of Alternative Diagnostic Tools In The Diag...mentioning

confidence: 99%

Diagnosis of Paediatric Obstructive Sleep-Disordered Breathing beyond Polysomnography

Borrelli,

Corcione,

Cimbalo

et al. 2023

Children

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Obstructive sleep-disordered breathing (SDB) has significant impacts on health, and therefore, a timely and accurate diagnosis is crucial for effective management and intervention. This narrative review provides an overview of the current approaches utilised in the diagnosis of SDB in children. Diagnostic methods for SDB in children involve a combination of clinical assessment, medical history evaluation, questionnaires, and objective measurements. Polysomnography (PSG) is the diagnostic gold standard. It records activity of brain and tibial and submental muscles, heart rhythm, eye movements, oximetry, oronasal airflow, abdominal and chest movements, body position. Despite its accuracy, it is a time-consuming and expensive tool. Respiratory polygraphy instead monitors cardiorespiratory function without simultaneously assessing sleep and wakefulness; it is more affordable than PSG, but few paediatric studies compare these techniques and there is optional recommendation in children. Nocturnal oximetry is a simple and accessible exam that has high predictive value only for children at high risk. The daytime nap PSG, despite the advantage of shorter duration and lower costs, is not accurate for predicting SDB. Few paediatric data support the use of home testing during sleep. Finally, laboratory biomarkers and radiological findings are potentially useful hallmarks of SDB, but further investigations are needed to standardise their use in clinical practice.

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Level of urinary catecholamine in children with Sleep Disordered Breathing: A systematic review and meta-analysis

Cited by 11 publications

References 44 publications

Characteristics of the Attentional Network in Children with Sleep-Disordered Breathing

Characteristics of the Attentional Network in Children with Sleep-Disordered Breathing

Cardiovascular Disease from Pathophysiology to Risk Estimation: Is Inflammation Estimated through Perivascular Attenuation on Computed Tomography the Key?

Diagnosis of Paediatric Obstructive Sleep-Disordered Breathing beyond Polysomnography

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