Levels of Circulating Intercellular Adhesion Molecule-1 and -3 but Not Circulating Endothelial Leucocyte Adhesion Molecule Are Increased in Patients With Rheumatoid Vasculitis

Abstract

The aim of this study was to investigate whether levels of circulating adhesion molecules reflect vascular inflammation in rheumatoid vasculitis (RV). Levels of circulating intercellular adhesion molecule-1 (cICAM-1), c-ICAM-3 and circulating endothelial leucocyte adhesion molecule (cE-selectin) were determined in 14 patients with RV and compared to 47 patients with rheumatoid arthritis (RA) and 100 healthy donors (HD). Enzyme-linked immunosorbent assays were used to quantify cICAM-1, cICAM-3 and cE-selectin. We found that in RV significantly (P < 0.0001) elevated levels of cICAM-1 and cICAM3, but not cE-selectin, were found when compared with RA patients. Levels > 2 S.D. above the mean level of HD were present for cICAM-1, cICAM-3 and cE-selectin in 57, 71 and 21%, respectively of patients with RV and 2, 21 and 44%, respectively of the RA patients. Increased levels of both cICAM-1 and cICAM-3 were found in 43% of the RV patients and in none of the RA patients. Comparison of the serum levels of patients studied in an active and inactive phase of RV revealed significantly lower levels of cICAM-3 levels in the inactive phase. In conclusion we find that determination of cICAM-1 and cICAM-3 may be useful as a marker of vascular inflammation in patients with RV.

Soluble intercellular adhesion molecule 1 in spondylarthropathies

“…This is in agreement with previous papers [5,6] whereas other studies have reported elevated levels in this condition [7,8]. Our RA patients were older than the SpA patients and controls, but Cush et al [4] and Kuryliszyn-Moskal et al [8] did not find a correlation between slCAM-1 and age in RA.…”

“…In rheumatoid arthritis (RA), several studies have reported normal [5,6] or elevated levels of sICAM-1 [4,7] with sometimes a weak correlation with disease activity [4] or extra-articular features such as vasculitis [5,8]. In a previous study [9] we found an increased expression of LFA-1 on the surface of granulocytes in spondylarthropathies and LFA-1 expression correlated with total IgA levels in the serum of these patients.…”

Clinical Relevance of Cytokines, Chemokines and Adhesion Molecules in Systemic Vasculitis

“…The ICAM-1 protein, TNF-, and E-selectin are expressed in ECs and perivascular mononuclear cells in areas of microvascular damage in the salivary glands of RV patients (Flipo et al 1997). Furthermore, RV patients have elevated levels of sICAM-1 (Voskuyl et al 1995;Kuryliszyn-Moskal, Bernacka et al 1996;Witkowska et al 2003). In addition, Voskuyl et al (Voskuyl, Martin et al 1995) demonstrated the involvement of ICAM-3 and ICAM-1 in patients with RV.…”

“…Furthermore, RV patients have elevated levels of sICAM-1 (Voskuyl et al 1995;Kuryliszyn-Moskal, Bernacka et al 1996;Witkowska et al 2003). In addition, Voskuyl et al (Voskuyl, Martin et al 1995) demonstrated the involvement of ICAM-3 and ICAM-1 in patients with RV. This involvement suggests that ICAM-1 and ICAM-3 in serum may be useful markers of vascular inflammation in patients with RV, and these proteins may play a crucial role in vasculitis development in RA.…”

Cutaneous Vasculitis in Patients With Rheumatoid Arthritis

“…В развитии васкулита при РА могут участвовать моле-кулы межклеточной адгезии 1 (ICAM1), Е-селектин и фак-тор некроза опухоли α (ФНОα) [18,19].…”