Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

Abstract

Aim: Cardiac and renal diseases are common disorders that frequently coexist. We tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (EDA-MPs; CD31 CD42b AN V ) and platelet-derived apoptotic microparticles (PDA-MPs; CD31 CD42b AN V ) are useful biomarkers for predicting the presence of cardiorenal disease (CRD). Methods: A total of 68 patients with chronic kidney disease (CKD) and angina pectoris (CKD-AP) undergoing cardiac catheterization were prospectively enrolled into group 1, 10 patients with coronary artery disease (CAD) without CKD were enrolled into group 2 (CAD CKD ) and 10 patients without CAD and CKD were enrolled into group 3 (CAD CKD ). Results: The serum creatinine levels were significantly higher, whereas the estimated glomerular filtration rates (eGFRs) were significantly lower, in group 1 than in the other two groups (all p 0.02). The circulating levels of EDA-MPs and PDA-MPs did not differ between the patients with and without CKD (all p 0.2). However, the circulating levels of EDA-MPs and PDA-MPs were significantly higher in group 2 than in groups 1 and 3 (all p 0.03). In addition, differences were noted in the circulating EDA-MP and PDA-MP levels between groups 1 and 3, although without statistical significance (all p 0.09). Meanwhile, among the CKD patients, the subgroup analysis showed that the levels of MPs were significantly higher in those with CAD than in those without (all p 0.001), while a multivariate analysis demonstrated that CAD was the only factor independently predictive of high levels of circulating EDA-MPs and PDA-MPs (p 0.033). Conclusions:The link with increased circulating levels of MPs is more consistent in patients with CAD than in those with CKD. J Atheroscler Thromb, 2015; 22: 247-256.

Temporal Trends in Clinical Outcomes Following Percutaneous Coronary Intervention in Patients with Renal Insufficiency

“…Renal insufficiency is considered to be an independent risk factor for CAD 1–6) ; furthermore, CAD patients with renal insufficiency have worse clinical outcomes compared with patients without renal insufficiency 7–9) . Coronary revascularization has been demonstrated to be effective in improving prognosis in CAD patients with renal insufficiency 18, 19) .…”

“…Renal insufficiency is an independent risk factor for coronary artery disease (CAD) 1–6) . Furthermore, previous studies reported that CAD patients with renal insufficiency had worse clinical outcomes compared with those without renal insufficiency 7–9) .…”

Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis

“…Stenting in stable coronary atherosclerotic lesions is associated with a substantial release of pMVs (Horn et al, 2015). Interestingly, the link with increased circulating pMV levels is more consistent with coronary artery disease patients than in those with chronic kidney disease (Chen et al, 2014). Indeed, overproduction of pMVs and platelet activation with suppressed aggregation may be even implicated in the pathogenesis of coagulation abnormalities in children with congenital heart disease (Horigome et al, 2002; Ismail and Youssef, 2012).…”

Extracellular Vesicles in Renal Diseases

“…Circulating MPs have been the most studied EVs in humans with CKD and ESRD, conditions in which MPs have been associated with endothelial dysfunction, 67 cardiovascular mortality, 68,69 increased risk for calcification, 70,71 anemia, 72,73 and disease-specific alteration in coagulation. 74 In a study of a heterogeneous group of patients with chronic renal failure and those on peritoneal dialysis and hemodialysis, all patients compared with healthy controls had higher levels of endothelial-derived microparticles (EMPs) and MPs of leukocyte origin.…”