Levels of Tumor Necrosis Factor-Alpha, Interleukin-6, and Interferon- Gamma during the Active Phases of Bechet’s Disease, Pustular Psoriasis, Palmoplantar Pustulosis, and Stevens-Johnson Syndrome: A Pilot Study

Nakamura, Satoshi

doi:10.4172/2155-9554.1000175

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…The present study found a significant positive correlation between serum levels of TNF-a and PASI score (P = 0.03); this result is in agreement with that of some investigators [26,29] and in disagreement with that of others [25].…”

Section: Discussionsupporting

confidence: 90%

Study of tumor necrosis factor-α-308 promoter polymorphism in psoriasis vulgaris

El-Farargy¹,

Farag²,

Azmy³

et al. 2014

Journal of the Egyptian Womenʼs Dermatologic Society

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Section: Discussionsupporting

confidence: 90%

Study of tumor necrosis factor-α-308 promoter polymorphism in psoriasis vulgaris

El-Farargy¹,

Farag²,

Azmy³

et al. 2014

Journal of the Egyptian Womenʼs Dermatologic Society

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“…Similarly, Kyolic aged garlic extract was found to significantly reduce the inflammatory marker TNF-alpha in hypertensive patients (3). High ratios of IL-6/ TNF-α were found relevant in the modulation of both innate and adaptive immune responses in newborns (24), and play a role in the etiology of a number of autoimmune diseases (25).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Kyolic Aged Garlic Extract on Gut Microbiota, Inflammation, and Cardiovascular Markers in Hypertensives: The GarGIC Trial

Ried¹,

Travica²,

Sali³

2018

Front. Nutr.

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Background: Previous research suggests Kyolic-aged-garlic-extract to be effective in reducing blood pressure in a large proportion of hypertensive patients similar to first-line standard antihypertensive medication. High blood pressure has been linked to gut dysbiosis, with a significant decrease in microbial richness and diversity in hypertensives compared to normotensives. Furthermore, gut dysbiosis has been associated with increased inflammatory status and risk of cardiovascular events.Objective: To assess the effect of Kyolic aged GARlic extract on Gut microbiota, Inflammation, and Cardiovascular markers, including blood pressure, pulse wave velocity and arterial stiffness.Methods: A total of 49 participants with uncontrolled hypertension completed a double-blind randomized placebo-controlled trial of 12-weeks, investigating the effect of daily intake of aged-garlic-extract (1.2 g containing 1.2 mg S-allylcysteine) or placebo on blood pressure, pulse wave velocity and arterial stiffness, inflammatory markers, and gut microbiota.Results: Mean blood pressure was significantly reduced by 10 ± 3.6 mmHg systolic and 5.4 ± 2.3 mmHg diastolic compared to placebo. Vitamin B12 status played a role in responsiveness to garlic on blood pressure in 17% of patients. Garlic significantly lowered central blood pressure, pulse pressure and arterial stiffness (p < 0.05). Trends observed in inflammatory markers TNF-α and IL-6 need to be confirmed in larger trials. Furthermore, aged-garlic-extract improved gut microbiota, evident by higher microbial richness and diversity with a marked increase in Lactobacillus and Clostridia species after 3 months of supplementation.Conclusions: Kyolic-aged-garlic-extract is effective in reducing blood pressure in patients with uncontrolled hypertension, and has the potential to improve arterial stiffness, inflammation, and gut microbial profile. Aged-garlic-extract is highly tolerable with a high safety profile as a stand-alone or adjunctive antihypertensive treatment, with multiple benefits for cardiovascular health.Trial Registration: Australian New Zealand Clinical Trial Registry ACTRN12616000185460 (https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=370096)

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Levels of Tumor Necrosis Factor-Alpha, Interleukin-6, and Interferon- Gamma during the Active Phases of Bechet’s Disease, Pustular Psoriasis, Palmoplantar Pustulosis, and Stevens-Johnson Syndrome: A Pilot Study

Cited by 2 publications

References 6 publications

Study of tumor necrosis factor-α-308 promoter polymorphism in psoriasis vulgaris

Study of tumor necrosis factor-α-308 promoter polymorphism in psoriasis vulgaris

The Effect of Kyolic Aged Garlic Extract on Gut Microbiota, Inflammation, and Cardiovascular Markers in Hypertensives: The GarGIC Trial

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