Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders
Christina Michalski,
Zhexing Wen
Abstract:Communication between the immune and the nervous system is essential for human brain development and homeostasis. Disruption of this intricately regulated crosstalk can lead to neurodevelopmental, psychiatric, or neurodegenerative disorders. While animal models have been essential in characterizing the role of neuroimmunity in development and disease, they come with inherent limitations due to species specific differences, particularly with regard to microglia, the major subset of brain resident immune cells. … Show more
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