The growing complexity of cybersecurity threats demands a robust framework that integrates various security domains, addressing the issue of disjointed security practices that fail to comply with evolving regulations. This paper introduces a novel information security management and compliance framework that integrates operational, technical, human, and physical security domains. The aim of this framework is to enable organizations to identify the requisite information security controls and legislative compliance needs effectively. Unlike traditional approaches, this framework systematically aligns with both current and emerging security legislation, including GDPR, NIS2 Directive, and the Artificial Intelligence Act, offering a unified approach to comprehensive security management. The experimental methodology involves evaluating the framework against five distinct risk scenarios to test its effectiveness and adaptability. Each scenario assesses the framework’s capability to manage and ensure compliance with specific security controls and regulations. The results demonstrate that the proposed framework not only meets compliance requirements across multiple security domains but also provides a scalable solution for adapting to new threats and regulations efficiently. These findings represent a significant step forward in holistic security management, indicating that organizations can enhance their security posture and legislative compliance simultaneously through this integrated framework.