Levodopa Challenge Test Predicts STN-DBS Outcomes in Various Parkinson’s Disease Motor Subtypes: A More Accurate Judgment

Abstract

Background. The relationship between the levodopa challenge test (LDCT) and postoperative subthalamic nucleus-deep brain stimulation (STN-DBS) benefits is controversial in patients with Parkinson’s disease (PD). We aim to evaluate the value of total levodopa response (TLR) and symptom levodopa response (SLR) in predicting postoperative improvement in different PD motor subtypes. Methods. Studies were split into a training set (147 patients) and a validation set (304 patients). We retrospectively collected data from 147 patients who received the Unified Parkinson’s Disease Rating Scale- (UPDRS-) III and the Parkinson’s Disease Questionnaire- (PDQ-) 39 evaluation. Patients were classified into tremor-dominant (TD), akinetic-rigid-dominant (AR), and mixed (MX) groups. Clinically important difference (CID) was employed to dichotomize DBS effects. For patients in each subtype group from the training set, we used the correlation and receiver operator characteristic (ROC) curve analyses to explore the strength of their relations. Areas under the curve (AUCs) were calculated and compared through the DeLong test. Results developed from the training set were applied into the validation set to predict postoperative improvement in different PD motor subtypes. Results. In the validation cohort, TLR significantly correlated with postoperative motor ( p < 0.001 ) and quality of life (QOL) ( p < 0.001 ) improvement in the MX group. The AUC between TLR and UPDRS-III (TU) is 0.800. The AUC between TLR and PDQ-39 (TP) is 0.770. An associated criterion in both TU and TP is around 50%. In the AR group, strong correlation was only found in SLR and PDQ-39 (SP) ( p < 0.001 ). And the AUC of SP is significantly larger than that in TLR and PDQ-39 (TP) ( p = 0.034 ). An associated criterion in SP is around 37%. No significant correlation was found in the TD group. Conclusions. We provide a more accurate judgment for LDCT. TLR strongly correlated with postoperative UPDRS-III and PDQ-39 improvement in MX patients. A TLR > 50 % may indicate a higher possibility of clinically meaningful benefits from STN-DBS comparing to medication only. SLR can well predict QOL improvement in AR patients. Similarly, a SLR > 37 % may indicate a higher possibility of clinically significant benefits from STN-DBS. LDCT provides limited information for TD patients.

Deep brain stimulation of the subthalamic nucleus for Parkinson’s disease: A network imaging marker of the treatment response

“…In this regard, the LCT is thought to provide an estimate of the maximum bene t a patient is likely to experience from STN stimulation. The cutoff criterion for the LCT has been found to vary considerably, and patient strati cation according to this measure can be unreliable [41][42][43]. An unexpected nding in this study was the correlation seen at both sites between stimulation-mediated outcomes and STN StimNet expression recorded in the baseline OFF condition.…”

Morphologic brain network predicts levodopa responsiveness in Parkinson disease

“…It was reported that patients with a motor symptom improvement rate of <30% in the l-dopa impact test responded well to DBS (Zheng et al, 2021); and at our center, DBS was effective in some patients with <33% improvement in the LCT. As the LCT does not fully reflect brain function, it is important to establish other methods for predicting the response of PD patients to DBS.…”

“…A 30% or 33% improvement in Unified Parkinson’s Disease Rating Scale (UPDRS)-III score in the LCT has been set as a threshold for selecting candidates for DBS ( Defer et al, 1999 ); however, it is unclear how this can predict the effectiveness of the DBS operation. It was reported that patients with a motor symptom improvement rate of <30% in the l -dopa impact test responded well to DBS ( Zheng et al, 2021 ); and at our center, DBS was effective in some patients with <33% improvement in the LCT. As the LCT does not fully reflect brain function, it is important to establish other methods for predicting the response of PD patients to DBS.…”

Cerebrotendinous xanthomatosis tremor successfully controlled post-ventral intermediate nucleus-deep brain stimulation: a case report

“…Although the predictive value of the levodopa challenge score on parkinsonian symptoms control with DBS implantation is well documented ( 13 ) it was unclear whether the patient would benefit from the procedure given his mixed rest and action-postural tremor alongside a poor levodopa challenge score. Focusing on the limiting tremor symptoms impacting his dominant hand, meaningful improvements were achieved.…”