Lewis Blood-Type May Affect the Incidence of Gastrointestinal Cancer

Koprowski, Hilary; Błaszczyk, M; Steplewski, Zenon; Brockhaus, Manfred; Magnani, John L.; Ginsburg, Victor

doi:10.1016/s0140-6736(82)92402-3

Cited by 104 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1) had very low Ca 19-9 levels. This may be due to the close relationship of this antigen to the Lewis blood group system, a relationship to which the investigations of Koprowski et al [5] have already drawn attention: approximately 10 % of the population in Europe is Lewis-negative…”

Section: Discussionmentioning

confidence: 99%

Ca 19–9 in Seminal Plasma of Infertile Men

Panidis

Vlassis

Papameletiou

et al. 1988

Archives of Andrology

View full text Add to dashboard Cite

Ca 19-9 levels were determined by radioimmunoassay in the seminal plasma of 108 men divided in (a) eight groups according to etiological diagnosis of infertility and (b) two groups on the basis of normal or abnormal spermiogram. The mean Ca 19-9 (or Ca 19-9-like activity) in the seminal plasma was 114.6 times higher than the upper limit in normal serum. A statistically significant difference was noted in the antigen levels between men with normal and those with abnormal spermiograms, although with wide overlapping of the individual values. There was no correlation between Ca 19-9 levels and the variables of the spermiogram. The prostate seems to be the main site of origin of Ca 19-9 or Ca 19-9-like activity in the seminal plasma.

show abstract

Section: Discussionmentioning

confidence: 99%

Ca 19–9 in Seminal Plasma of Infertile Men

Panidis

Vlassis

Papameletiou

et al. 1988

Archives of Andrology

View full text Add to dashboard Cite

show abstract

“…The cancer-associated carbohydrate antigen Ca 19-9, which is structurally identical with a sialylated Le" blood-group determinant of a inonoganglioside [I] and a mucin [3], has been suggested to be biosynthetically related to a blood-group Lea-active precursor saccharide [4]. In accordance with this, the antigen was found in saliva from most normal individuals belonging to the Le(a + b -) or Le(a-b+) blood group, but not on salivary mucins from Le(a -b-) donors [5].…”

mentioning

confidence: 99%

Primary structures and Lewis blood-group-dependent expression of major sialylated saccharides from mucus glycoproteins of human seminal plasma

et al. 1985

View full text Add to dashboard Cite

The primary structures of four major sialylated saccharide alditols derived from mucus glycoproteins of human seminal plasma were established by fast-atom-bombardment mass spectrometry and methylation analysis. Anomeric configurations of the glycosidic bonds were determined by exoglycosidase digestion and C r 0 3 oxidation.GalN Ac-01 Based on quantitative data from high-pressure liquid chromatography and on structural information, the biosynthetic pathways for neutral and sialylated saccharides related to the Lewis system were proposed. Expression of saccharides A 6, A 7 and A 8 and their asialo counterparts, which are characterized by antigenic determinants H, Le" and Ley, respectively, is qualitatively and quantitatively dependent on the Lewis blood type of the respective donor and correlates with Ca 19-9 activity of its seminal plasma.

show abstract

“…CA19-9 is considered to be a serum marker for carcinomas in the gastrointestinal tract and pancreas, and is also found in carcinomas in the bladder, breast, kidney, and so on. 13,16,18) Therefore, in addition to histochemical studies, careful systemic examinations are indispensable to distinguish choroid plexus carcinoma from metastasis. In the present case, whole body examinations including scintigraphy and positron emission tomography found no evidence of a primary focus of metastasis.…”

Section: Discussionmentioning

confidence: 99%

Choroid Plexus Carcinoma Secreting Carbohydrate Antigen 19-9 in an Adult-Case Report-

Osada

Mori

Yamamoto

et al. 2006

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 53-year-old man presented with a choroid plexus carcinoma in the body of the right lateral ventricle manifesting as gait disturbance due to left mild hemiparesis and papilledema. Subtotal removal of the tumor was performed. Histological examination revealed well-differentiated papillary adenocarcinoma. Immunohistochemical examination showed intense reactivity for carbohydrate antigen 19-9 (CA19-9). The serum level of CA19-9 was significantly high, but decreased rapidly after radiation therapy. Systemic examinations found no malignancy in other organs. This second case of choroid plexus carcinoma producing CA19-9 indicates that CA19-9 may be a useful marker of choroid plexus carcinoma.

show abstract

Lewis Blood-Type May Affect the Incidence of Gastrointestinal Cancer

Cited by 104 publications

References 9 publications

Ca 19–9 in Seminal Plasma of Infertile Men

Ca 19–9 in Seminal Plasma of Infertile Men

Primary structures and Lewis blood-group-dependent expression of major sialylated saccharides from mucus glycoproteins of human seminal plasma

Choroid Plexus Carcinoma Secreting Carbohydrate Antigen 19-9 in an Adult-Case Report-

Contact Info

Product

Resources

About