LHRH-functionalized superparamagnetic iron oxide nanoparticles for breast cancer targeting and contrast enhancement in MRI

Meng, Juan; Fan, Jun; Galiana, Gigi; Branca, Rosa T.; Clasen, Patrick L.; Ma, Shaohua; Zhou, Jianxin; Leuschner, Carola; Kumar, Challa S. S. R.; Hormes, J.; Otiti, Tom; Beye, Aboubaker Chédikh; Harmer, M. P.; Kiely, Christopher J.; Warren, W. S.; Haataja, Mikko; Soboyejo, W. O.

doi:10.1016/j.msec.2008.09.039

Cited by 82 publications

(34 citation statements)

References 30 publications

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“…More recently studied ligands, though, include peptides (e.g. chlorotoxin [31], RGD [32], lung cancer targeting peptide [33], CREKA [34], bombesin [35], F3 [36, 37], A54 [38], LHRH [39]), antibodies (e.g. Anti-HER2 [40], Anti-EGFR/EGFRvIII [41, 42]), and small molecules (e.g.…”

Section: Targeting Mnps To Tumorsmentioning

confidence: 99%

Cancer theranostics: the rise of targeted magnetic nanoparticles

Cole¹,

Yang²,

David³

2011

Trends in Biotechnology

380

221

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Interest in utilizing magnetic nanoparticles (MNP) for biomedical applications has grown considerably over the past two decades. This excitement is driven in large part by the success of MNPs as contrast agents in magnetic resonance imaging (MRI). The recent investigative trend with respect to cancer has continued down a diagnostic path, but has also turned toward concurrent therapy – giving rise to the distinction of MNPs as potential “theranostics”. Here we review both the key technical principles of MNPs and the ongoing advancement toward a cancer theranostic MNP. Recent progress in diagnostics, hyperthermia treatments, and drug delivery are all considered. We conclude by identifying current barriers to clinical translation of MNPs and offer considerations for their future development.

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Section: Targeting Mnps To Tumorsmentioning

confidence: 99%

Cancer theranostics: the rise of targeted magnetic nanoparticles

Cole¹,

Yang²,

David³

2011

Trends in Biotechnology

380

221

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“…The functionalization of these nanoparticles with targeting agents have been also used for targeted imaging via the site-specific accumulation of nanoparticles at the targets of interest. [62][63][64] The recent research on SPIO nanoparticles is opening up wide horizons for their use as diagnostic agents in MRI as well as for drug delivery vehicles. The current optimization of the properties of these magnetic particles is directed to (1) provide an increase in magnetic nanoparticle concentration in blood vessels, (2) reduce early clearance from the body, (3) minimize nonspecific cell interactions, thus minimizing side effects, and (4) increase their internalization efficiency within target cells, thus reducing the total dose required.…”

Section: Iron-oxide Based Contrast Agents For Mri Applicationmentioning

confidence: 99%

Red Blood Cells as Carriers of Iron Oxide-Based Contrast Agents for Diagnostic Applications

Antonelli¹,

Magnani²

2014

j biomed nanotechnol

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New biomedical strategies are being developed to improve disease detection, therapeutic monitoring, and treatment efficacy in several contexts for example in anti-angiogenic chemotherapy, and prevention of cardiovascular disorders. The use of contrast agents to improve the sensitivity and resolution of diagnostic imaging modalities, detect lesions or organs, and evaluate organ function was immediately recognized. In the last years, superparamagnetic iron oxide (SPIO) nanoparticles have been clinically used as MRI contrast agents for the diagnosis of liver diseases, due to their ability to shorten T 2 * relaxation times. After the intravenous administration, SPIO nanoparticles are rapidly eliminated from the bloodstream since they are selectively taken up by the Kupffer cells in the liver, spleen, and bone marrow thus improving the clinical tumor detection in these tissues. However, for the investigation of vascular system including functional cardiac diagnosis, angiography and cardiac wall motion assessment, contrast agents with long blood circulation time would be necessary. In fact, imaging applications for long-term monitoring require the repeated administration of SPIO bolus injections, which complicates quantitative comparisons due to the temporal variations in concentration. In this context, researchers have developed several SPIO delivery systems based on red blood cells (RBCs) used as carriers to increase the blood circulation time of contrast agents. Encapsulation of SPIOs into RBCs appears the most attractive strategy to obtain magnetic RBC-constructs suitable for MRI and MPI analyses of blood vascular system.

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“…International collaborations among the United States and Africa, [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] J oint US-Africa Materials Institute (JUAMI) will be held December 10-21, 2018, in Kampala, Uganda. JUAMI features tutorials on cutting-edge energy materials topics, hands-on experiments and learning activities, and research seminars.…”

Section: In Summarymentioning

confidence: 99%

Strengthening diversity and cooperation through international collaborations: A focus on Africa, South America, and the Caribbean

Soboyejo

Madsen

2018

MRS Bull.

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Africa is the second largest continent in terms of size and population.1,2 With approximately 1.256 billion people (about 15% of the world’s population) and a land area of 30.3 million square kilometers (including adjacent islands), it occupies about 20.4% of the earth’s total land area.1 A significant fraction of the people in the Caribbean* and South America are of African descent, and there are many historical and cultural links among the people of these regions.3 South America has 422.5 million people, and the Caribbean has about 39.12 million people;1 hence, the total population of all three areas represents about 20% of the world’s population.1,2 Similarities in climate also mean that common approaches can be explored for establishing sustainable building materials, and the range of development indices offer unique opportunities for collaborations in research and education that can facilitate human development.4

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LHRH-functionalized superparamagnetic iron oxide nanoparticles for breast cancer targeting and contrast enhancement in MRI

Cited by 82 publications

References 30 publications

Cancer theranostics: the rise of targeted magnetic nanoparticles

Cancer theranostics: the rise of targeted magnetic nanoparticles

Red Blood Cells as Carriers of Iron Oxide-Based Contrast Agents for Diagnostic Applications

Strengthening diversity and cooperation through international collaborations: A focus on Africa, South America, and the Caribbean

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