Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy

The search for orally active medications through combinatorial chemistry

“…Limited variation is available but the library succeeded in meeting the objectives of the study so must be regarded as successful. 101 The degree of complexity and the magnitude of a library is expanded enormously when a library becomes the source of another library (a library squared). Not many of these have yet appeared involving nonpeptides but the work of Nielsen, illustrated in Figure 58, is pioneering in this respect.…”

Combinatorial Peptide Libraries: Robotic Synthesis and Analysis by Nuclear Magnetic Resonance, Mass Spectrometry, Tandem Mass Spectrometry, and High-Performance Capillary Electrophoresis Techniques

“…A limiting the concept has been extended to nonpeptide collecfactor is certainly the amount of available resin which tions, such as benzodiazepines, biphenyls, cinnamates, can be handled in synthesis. Due to the divide proceor propanediol derivatives (39,40). It is unlikely that dure in which the smallest element to be separated is the exploitation of combinatorial methods will not lead the bead, there is a single peptide type on each bead to the discovery of new chemical entities which are (one bead/one peptide).…”

Synthesis of Novel Functionalized Polymers for the Diastereoselective Protonation of Chiral Enolates

“…[5] Alternatively, the ether 6 was formed with 51% yield by treatment of 4 with ethyl 2,5-dihydroxybenzoate and potassium carbonate (Scheme 2). [6] The formation of the homopolymers 7a/8a, as well as of statistical copolymers with 5, 9 or 15 equiv.…”