Lichen planus and dyslipidemia: a systematic review and meta‐analysis of observational studies

Lai, Yi Chun; Yew, Yik Weng; Schwartz, Robert A.

doi:10.1111/ijd.13234

Cited by 40 publications

(47 citation statements)

References 35 publications

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“…In our study we did not find a significant association with autoimmune diseases except for thyroid disease ( López-Jornet et al, 2014 ). A meta-analysis of patients with LP found that they are at an increased risk for hyperlipidemia ( Lai et al, 2016 ). Interestingly in our study, we found a lower risk of dyslipidemia compared with controls and further investigation is necessary to determine the true risk.…”

Section: Discussionmentioning

confidence: 99%

“…This pathophysiologic mechanism is thought to be similar to lichen planus (LP), which LPP is believed to be a follicular variant of ( Bolduc et al, 2016 ). Although there are known associations of LP with autoimmune disorders, hyperlipidemia, metabolic syndrome, hypothyroidism, anxiety, and depression, the relationship between LPP and other diseases has been largely unexplored ( Garcia-Pola et al, 2016 , Hirota et al, 2013 , Lai et al, 2016 , López-Jornet et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients

Brankov

Conic

Atanaskova-Mesinkovska

et al. 2018

International Journal of Women's Dermatology

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BackgroundLichen planopilaris (LPP) is a rare, cicatricial, lymphocyte-mediated alopecia that is thought to have an autoimmune pathogenesis and possibly related to other autoimmune diseases. However, data are limited and studies that examine comorbid conditions are lacking.ObjectivesWe sought to determine the prevalence of systemic comorbid conditions, nutritional deficiencies, psychological problems, and skin cancers in patients with LPP.MethodsWe identified 334 patients with LPP who were seen in the Department of Dermatology at the Cleveland Clinic Foundation between 2000 and 2016. Patients with LPP were compared with 78 control patients with a diagnosis of seborrheic dermatitis.ResultsThere were more female patients with LPP compared with the controls (93.1% vs. 79.5%; p < .001) but the average age did not differ (54.77 ± 12.83 vs. 52.19 ± 15.37; p = .12). Conditions positively associated with LPP were Hashimoto’s thyroiditis (6.3% vs. 0%; p = .023), hypothyroidism (24.3% vs. 12.8%; p = .028), and hirsutism (11.4% vs. 1.3%; p = .006). Negatively associated conditions were allergic rhinitis (15% vs. 24.4%; p = .046), diabetes mellitus type II (11.7% vs. 21.8%; p = .019), hyperlipidemia (38.6% vs. 52.6%; p = .024), vitamin D deficiency (50% vs. 65.4%; p = .014), depression (15.6% vs. 28.9%; p = .018), and sleep problems (7.5% vs. 29.5%; p < .001).ConclusionsOur study further emphasizes that dermatologists should screen patients with LPP for autoimmune disorders that are associated with LPP and complete a full metabolic workup to avoid missing other abnormalities. The importance of atopy, autoimmune disorders, endocrine disorders, nutritional deficiencies, psychological problems, and skin cancers in patients with scarring alopecia should be better understood.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients

Brankov

Conic

Atanaskova-Mesinkovska

et al. 2018

International Journal of Women's Dermatology

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“…A disrupted plasma lipid profile is observed in a number of inflammatory dermatoses, e.g. psoriasis [22] or lichen planus [23]. A relationship between disorders in lipid metabolism and androgenetic alopecia was confirmed in two metaanalyses.…”

Section: Nadciśnienie Tętniczementioning

confidence: 86%

“…dyslipideMiA Dyslipidemie należą do najważniejszych modyfikowalnych czynników ryzyka sercowo-naczyniowego. Zaburzony profil lipidów w osoczu obserwuje się w wielu dermatozach zapalnych, takich jak łuszczyca [22] i liszaj płaski [23]. Związek między zaburzeniami gospodarki lipidowej a łysieniem androgenowym potwierdzono w dwóch metaanalizach.…”

Section: Insulin Resistanceunclassified

Androgenetic alopecia as a cardiovascular risk factor

Wernicka¹,

Wyzgał²,

Waśkiel‐Burnat³

et al. 2018

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Androgenetic alopecia is the most common cause of chronic hair loss. The first reports indicating the relationship between androgenetic alopecia and cardiovascular diseases were published in the 1970s. Epidemiological studies confirmed a more frequent occurrence of ischaemic heart disease, development of atherosclerosis and an increased risk of cardiovascular death in this group of patients. Metabolic syndrome and the presence of its components: arterial hypertension, dyslipidemia, insulin resistance and visceral obesity are more frequent in androgenetic alopecia. The pathomechanism of co-occurring androgenetic alopecia and cardiovascular diseases includes several factors such as genetic (increased sensitivity to androgens and activity of 5α-reductase), hormonal (increased concentration of insulin, aldosterone, leptin) and inflammatory (cytokines, free oxygen radicals). Androgenetic alopecia, especially when it begins before the age of 30, has been identified as an independent cardiovascular risk factor. Women and men with pattern hair loss should be closely monitored for other risk factors to start prophylaxis. streszczenie Łysienie androgenowe stanowi najczęstszą przyczynę utraty włosów u kobiet i mężczyzn. W latach 70. XX wieku pojawiły się pierwsze doniesienia wskazujące na związek łysienia androgenowego z chorobami układu krążenia. Późniejsze badania epidemiologiczne potwierdziły częstsze występowanie w tej grupie pacjentów choroby niedokrwiennej serca, przyspieszony rozwój miażdżycy oraz większe ryzyko zgonu z przyczyn sercowo-naczyniowych. U osób z łysieniem androgenowym częściej stwierdza się zespół metaboliczny oraz obecność jego poszczególnych składowych, takich jak nadciśnienie tętnicze, dyslipidemia, insulinooporność i otyłość trzewna. Patomechanizm współwystępowania łysienia androgenowego i chorób sercowo-naczyniowych jest złożony i obejmuje czynniki genetyczne (zwiększona wrażliwość na androgeny i aktywność 5α-reduktazy), hormonalne (zwiększone stężenie insuliny, aldosteronu, leptyny) oraz zapalne (cytokiny, wolne rodniki tlenowe). Łysienie androgenowe, zwłaszcza rozpoczynające się przed 30. rokiem życia, uznano za niezależny czynnik ryzyka sercowo-naczyniowego. Kobiety i mężczyźni z androgenową utratą włosów powinni być okresowo monitorowani w celu poszukiwania innych czynników ryzyka, aby jak najszybciej rozpocząć działania profilaktyczne.

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“…This pathophysiologic mechanism is thought to be similar to lichen planus (LP), which LPP is believed to be a follicular variant of (Bolduc et al, 2016). Although there are known associations of LP with autoimmune disorders, hyperlipidemia, metabolic syndrome, hypothyroidism, anxiety, and depression, the relationship between LPP and other diseases has been largely unexplored (Garcia-Pola et al, 2016;Hirota et al, 2013;Lai et al, 2016;López-Jornet et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients

2018

Journal of the American Academy of Dermatology

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Background: Lichen planopilaris (LPP) is a rare, cicatricial, lymphocyte-mediated alopecia that is thought to have an autoimmune pathogenesis and possibly related to other autoimmune diseases. However, data are limited and studies that examine comorbid conditions are lacking. Objectives: We sought to determine the prevalence of systemic comorbid conditions, nutritional deficiencies, psychological problems, and skin cancers in patients with LPP. Methods: We identified 334 patients with LPP who were seen in the Department of Dermatology at the Cleveland Clinic Foundation between 2000 and 2016. Patients with LPP were compared with 78 control patients with a diagnosis of seborrheic dermatitis. Results: There were more female patients with LPP compared with the controls (93.1% vs. 79.5%; p b .001) but the average age did not differ (54.77±12.83 vs. 52.19±15.37; p = .12). Conditions positively associated with LPP were Hashimoto's thyroiditis (6.3% vs. 0%; p = .023), hypothyroidism (24.3% vs. 12.8%; p = .028), and hirsutism (11.4% vs. 1.3%; p = .006). Negatively associated conditions were allergic rhinitis (15% vs. 24.4%; p = .046), diabetes mellitus type II (11.7% vs. 21.8%; p = .019), hyperlipidemia (38.6% vs. 52.6%; p = .024), vitamin D deficiency (50% vs. 65.4%; p = .014), depression (15.6% vs. 28.9%; p = .018), and sleep problems (7.5% vs. 29.5%; p b .001). Conclusions: Our study further emphasizes that dermatologists should screen patients with LPP for autoimmune disorders that are associated with LPP and complete a full metabolic workup to avoid missing other abnormalities. The importance of atopy, autoimmune disorders, endocrine disorders, nutritional deficiencies, psychological problems, and skin cancers in patients with scarring alopecia should be better understood.

show abstract

Lichen planus and dyslipidemia: a systematic review and meta‐analysis of observational studies

Cited by 40 publications

References 35 publications

Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients

Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients

Androgenetic alopecia as a cardiovascular risk factor

Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients

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