Lichen planus is associated with human herpesvirus type 7 replication and infiltration of plasmacytoid dendritic cells

Abstract

We conclude that HHV-7 replicates in LP lesions, but not in psoriasis, another inflammatory skin condition. HHV-7 is possibly involved in the pathogenesis of LP. These preliminary data make further research on this topic of interest.

Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus

“…Viral infections have recently been linked with OLP. Herpes Simplex virus-1 (HSV-1), Cytomegalovirus (CMV), Human Herpes virus-6 (HHV-6) (5, 6), Epstein-Barr virus (EBV) (5,7,8), Human Papilloma virus (HPV) (7) and Hepatitis C virus (HCV) (5,6) are virus types that have been studied in the etiopathogenesis of OLP. The aim of the present study was to assess the prevalence of HSV, EBV and HPV in histologically diagnosed OLP cases and to evaluate whether any specific clinical variants or histopathological features show a higher frequency of these viruses.…”

Evaluation of the Diagnostic Value of Plasmacytoid Dendritic Cells in Differentiating the Lymphocytic Cicatricial Alopecias

“…Specifically, recent evidence suggests a significant role of PDCs in LE pathogenesis [6,7]. Although PDCs have been shown to be increased in all forms of cutaneous LE and lichen planus, their prominence and patterns of distribution in the two diseases were different [6,7,8,9,10,11]. PDCs were constantly more prominent and detected as distinct perivascular and periadnexal clusters in LE, while in lichen planus they were commonly increased in the upper dermis and in the epidermis adjacent to necrotic keratinocytes [6,7,8,9,10,11].…”

“…Although PDCs have been shown to be increased in all forms of cutaneous LE and lichen planus, their prominence and patterns of distribution in the two diseases were different [6,7,8,9,10,11]. PDCs were constantly more prominent and detected as distinct perivascular and periadnexal clusters in LE, while in lichen planus they were commonly increased in the upper dermis and in the epidermis adjacent to necrotic keratinocytes [6,7,8,9,10,11]. Recently, Walsh et al [11 ]showed a significant diagnostic value of three criteria pertaining to PDCs (representation of ≥10% of inflammatory infiltrate, arrangement in clusters of ≥10 cells, presence at the dermoepidermal junction, DEJ) in differentiating hypertrophic LE from its mimickers.…”

Dermatological Skin Diseases Associated with Human Herpes Viruses 6, 7 and 8: Review

“…Otuz üç hastanın biyopsi örneklerinin değerlendirildiği bir çalışmada, liken planus lezyonlarında lezyonsuz deriye göre anlamlı derecede fazla HHV-7 ile enfekte hücreler izlenmiştir. 34 Ayrıca, nörosarkoidozlu bir hastada serebrospinal sıvıda HHV-7 saptandığı bildirilmiştir. 35 HHV-7 tanısında kullanılan testler ve testlerin değerlendirilmesindeki zorluklar HHV-6'ya benzemektedir.…”