Lichenoid eruptions in children

A Rare Case of Lichen Spinulosus After Golimumab Treatment

“…Ama bu birlikteliklerin tesadüfi olduğu dü- şünülmüştür. 1,3 Olgumuz da ankilozan spondilit olup, buna yönelik bir yıldır golimumab tedavisi almaktaidi.…”

“…Diğer sebepler; atopi, HIV enfeksiyonu ve lityum tedavisi olarak ortaya konmuştur. 2,3 Çalışmada, daha önce literatürde rastlanmayan ve erişkin bir hastada anti-tümör nekrozis faktör (TNF) tedavisi (golimumab) sonrası gelişen liken spinulozus olgusu ilk olması sebebiyle sunulması amaçlanmıştır.…”

Caso para diagnóstico

“…It is often localized, rarely disseminated, affects mostly the genital region, upper extremities, thorax and abdomen. [1][2][3][4][5][6][7][8][9][10] Occasionally, palmoplantar, oral and nail lesions (thickening, linear striations, pittings, and roughness) can be observed. 5,[7][8][9][10] There are atypical forms of the disease, described as keratodermic, follicular, vesicular, hemorrhagic, petechiae or perforating; 5,7-10 Köebner's phenomenon can also be found.…”

“…[1][2][3][4][5][6][7][8][9][10] Occasionally, palmoplantar, oral and nail lesions (thickening, linear striations, pittings, and roughness) can be observed. 5,[7][8][9][10] There are atypical forms of the disease, described as keratodermic, follicular, vesicular, hemorrhagic, petechiae or perforating; 5,7-10 Köebner's phenomenon can also be found. 1,2,4,5,7 The histopathology of this dermatosis is fairly typical, described as a lymphohistiocytic dermal infiltrate, sharply demarcated and round, surrounded by hyperplastic dermal pappilae (classically known as the "ball and clay" infiltrate), and parakeratosis with epidermal atrophy right above the infiltrate.…”

“…5,[7][8][9][10] There are atypical forms of the disease, described as keratodermic, follicular, vesicular, hemorrhagic, petechiae or perforating; 5,7-10 Köebner's phenomenon can also be found. 1,2,4,5,7 The histopathology of this dermatosis is fairly typical, described as a lymphohistiocytic dermal infiltrate, sharply demarcated and round, surrounded by hyperplastic dermal pappilae (classically known as the "ball and clay" infiltrate), and parakeratosis with epidermal atrophy right above the infiltrate. [1][2][3][4][5][7][8][9][10] Degenerative alterations of the basement layer, identical to those found in lichen planus lesions, may be seen, but contrary to lichen planus, direct immunofluorescence on lichen nitidus does not usually reveal immunoglobulin or complement deposits.…”