Lichenoid Tissue Reaction Induced by Local Transfer of Ia-Reactive T-Cell Clones. III. Role of Ia+ Keratinocytes in the Epidermotropic Migration of the T Cells

Clinical perspectives and murine models of lichenoid tissue reaction/interface dermatitis

“…The first murine model of LTR/IFD is mediated by autoaggressive CD4 + cells [40]. Adoptive transfer of some clones of murine helper T cells reactive to self MHC Ia induced LTR/IFD reaction in syngenic mice via IFN-g.…”

Cutaneous drug reactions

“…It has been proposed that there is an upregulation of MHC class II (Ia ^/HLA-DR) expression on keratinocytes, which produces epidermal thymocyte-activating factor (ETAF)/interleukin-I (IL-I). This promotes the preferential migration of epidermotropic lymphocytes [124]. A recent explanation is that certain drugs upregulate the ICAM-I expression on the basal ker-atinocytes, facilitating the adhesion of activated lymphocytes expressing LFA-I, with resultant tissue injury [125].…”

Induction and control of lichenoid tissue reactions

“…To date, three types of approach have been used to elucidate the mechanism(s) by which T cells migrate into the epidermis: the adherence reaction between T cells and cultured KC in vitro by Nickoloff and colleagues [26,27]; and the use of an animal model by us [41][42][43][44][45], in which the LTR is experimentally induced by intradermal inoculation of CD4 + autoreactive T cell clones. Another approach is examination of diseased human tissues for expression of adhesion molecules and cytokines [16,48,56,65].…”