Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis

Öztürk, Şule; Erkısa, Merve; Oran, Seyhan; Ulukaya, Engin; Çelikler, Serap; Arı, Ferda

doi:10.1080/01480545.2019.1573825

Cited by 22 publications

(24 citation statements)

References 23 publications

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“…As far as we are concerned, our study is the first to report on the apoptotic effects of Bryoria capillaris, therefore a comparison of results could not be performed for this lichen species. However, Bryoria capillaris extracts have been shown in various studies to have anti-proliferative effects on breast and lung cancer cells in a dose-dependent manner [33], which is also supported by our study. Lobaria pulmonaria (LP); Annexin V/7'AAD staining flow cytometry results (scatterplots), statistical analysis (bar graphs), ±SD changes between experiments (tables) and protein levels of PCNA, caspase-3 and PARP by western blot (right panel) on PC-3 cells with three different extraction of acetone (results compiled in A), ethanol (results compiled in B) and methanol (results compiled in C) respectively.…”

Section: Plos Onesupporting

confidence: 91%

“…In addition, Lobaria pulmonaria methanolic extract was reported to have a higher phenolic content, antioxidant activity, and reducing powers than U. longissima, U. florida [46]. Another study demonstrated that Lobaria pulmonaria has anti-proliferative effect on breast and lung cancer cells in a dose-dependent manner [33]. In our findings, prostate cancer cells exhibited significant cytotoxic effects in a dose and time-dependent manner in all three extraction methods.…”

Section: Plos Onesupporting

confidence: 65%

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Differential anti-proliferative and apoptotic effects of lichen species on human prostate carcinoma cells

et al. 2020

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Section: Plos Onesupporting

confidence: 91%

Section: Plos Onesupporting

confidence: 65%

Differential anti-proliferative and apoptotic effects of lichen species on human prostate carcinoma cells

et al. 2020

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“…Lichens contain diverse species and exhibit multiple functions such as in traditional medicine, and the preparation of food, perfume, and dye [ 32 ]. Recently, the cell killing effect of lichen extracts has received attention in the treatment of several types of cancer as shown by several studies [ 11 , 12 , 13 ] except for oral cancer. In the current study, we investigated the anticancer effect and mechanism of MEUB against oral cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…For example, methanol extract of U. intermedia Ach. was reported to induce cell killing of human breast and lung cancer cells [ 11 ]. Water extract of U. longissima Ach.…”

Section: Introductionmentioning

confidence: 99%

Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress

Tang

et al. 2020

Antioxidants

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Some lichens provide the resources of common traditional medicines and show anticancer effects. However, the anticancer effect of Usnproliea barbata (U. barbata) is rarely investigated, especially for oral cancer cells. The aim of this study was to investigate the cell killing function of methanol extracts of U. barbata (MEUB) against oral cancer cells. MEUB shows preferential killing against a number of oral cancer cell lines (Ca9-22, OECM-1, CAL 27, HSC3, and SCC9) but rarely affects normal oral cell lines (HGF-1). Ca9-22 and OECM-1 cells display the highest sensitivity to MEUB and were chosen for concentration effect and time course experiments to address its cytotoxic mechanisms. MEUB induces apoptosis of oral cancer cells in terms of the findings from flow cytometric assays and Western blotting, such as subG1 accumulation, annexin V detection, and pancaspase activation as well as poly (ADP-ribose) polymerase (PARP) cleavage. MEUB induces oxidative stress and DNA damage of oral cancer cells following flow cytometric assays, such as reactive oxygen species (ROS)/mitochondrial superoxide (MitoSOX) production, mitochondrial membrane potential (MMP) depletion as well as overexpression of γH2AX and 8-oxo-2′deoxyguanosine (8-oxodG). All MEUB-induced changes in oral cancer cells were triggered by oxidative stress which was validated by pretreatment with antioxidant N-acetylcysteine (NAC). In conclusion, MEUB causes preferential killing of oral cancer cells and is associated with oxidative stress, apoptosis, and DNA damage.

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“…The extract of Usnea intermedia exerted the strongest anti-proliferative effects especially observed in H1299 and MDA-MB-231 cells. The extract of U. intermedia also induced apoptosis confirmed via the phosphatidylserine translocation, increased caspase 3/7 activity, loss of mitochondrial membrane potential and the formation of pyknotic nuclei [113]. Isolates from Nemania serpens and Nemania aenea var.…”

Section: Determination Of Lichens' Extracts Effect Against Cancer Cellsmentioning

confidence: 92%

Anticancer Potential of Lichens’ Secondary Metabolites

et al. 2020

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Lichens produce different classes of phenolic compounds, including anthraquinones, xanthones, dibenzofuranes, depsides and depsidones. Many of them have revealed effective biological activities such as antioxidant, antiviral, antibiotics, antifungal, and anticancer. Although no clinical study has been conducted yet, there are number of in vitro and in vivo studies demonstrating anticancer effects of lichen metabolites. The main goal of our work was to review most recent published papers dealing with anticancer activities of secondary metabolites of lichens and point out to their perspective clinical use in cancer management.

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Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis

Cited by 22 publications

References 23 publications

Differential anti-proliferative and apoptotic effects of lichen species on human prostate carcinoma cells

Differential anti-proliferative and apoptotic effects of lichen species on human prostate carcinoma cells

Methanol Extract of Usnea barbata Induces Cell Killing, Apoptosis, and DNA Damage against Oral Cancer Cells through Oxidative Stress

Anticancer Potential of Lichens’ Secondary Metabolites

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