Licochalcone A exerts antitumor activity in bladder cancer cell lines and mice models

Zhang, Yue-Yang; Huang, Changjun; Liu, Shaoming; Wang, Bin; Guo, Jun; Bai, Jian-Qi; Fan, Xuetong; Jia, Yijun

doi:10.4314/tjpr.v15i6.6

Cited by 24 publications

(6 citation statements)

References 18 publications

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“…In C3H/HeN mice carrying UM-UC-3 cells, LA (40 mg/kg) enhanced the activity of cytotoxic T lymphocytes and increased the number of CD4 + CD25 + Foxp3+ regulatory T cells. This suggests that LA can be used to treat bladder cancer by modulating the immune response ( Zhang et al, 2016 ).…”

Section: Anticancer Effects Of Licochalcones On Tumor Cellsmentioning

confidence: 99%

Anticancer effects of licochalcones: A review of the mechanisms

et al. 2023

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Cancer is a disease with a high fatality rate representing a serious threat to human health. Researchers have tried to identify effective anticancer drugs. Licorice is a widely used traditional Chinese medicine with various pharmacological properties, and licorice-derived flavonoids include licochalcones like licochalcone A, licochalcone B, licochalcone C, licochalcone D, licochalcone E, and licochalcone H. By regulating the expression in multiple signaling pathways such as the EGFR/ERK, PI3K/Akt/mTOR, p38/JNK, JAK2/STAT3, MEK/ERK, Wnt/β-catenin, and MKK4/JNK pathways, and their downstream proteins, licochalcones can activate the mitochondrial apoptosis pathway and death receptor pathway, promote autophagy-related protein expression, inhibit the expression of cell cycle proteins and angiogenesis factors, regulate autophagy and apoptosis, and inhibit the proliferation, migration, and invasion of cancer cells. Among the licochalcones, the largest number of studies examined licochalcone A, far more than other licochalcones. Licochalcone A not only has prominent anticancer effects but also can be used to inhibit the efflux of antineoplastic drugs from cancer cells. Moreover, derivatives of licochalcone A exhibit strong antitumor effects. Currently, most results of the anticancer effects of licochalcones are derived from cell experiments. Thus, more clinical studies are needed to confirm the antineoplastic effects of licochalcones.

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Section: Anticancer Effects Of Licochalcones On Tumor Cellsmentioning

confidence: 99%

Anticancer effects of licochalcones: A review of the mechanisms

et al. 2023

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“…For instance, the administration of LA (40 mg/kg) to C3H/HeN mice bearing UM-UC-3 cells enhanced the activity of cytotoxic T lymphocytes and counts of CD4 + CD25 + Foxp3 + T regulatory T cells. Thus, LA might treat bladder cancer by modulating the tumor immune microenvironment ( Zhang et al, 2016 ). Administration of 10 mg/kg of LA attenuated the development of AngII-induced abdominal aortic aneurysm in mice through inhibiting expression of miR-181b, upregulating SIRT1/HO-1 signaling, and suppressing elastin degradation, matrix metalloproteinase and pro-inflammatory cytokines ( Hou et al, 2019 ).…”

Section: Anticancer Properties Of Lamentioning

confidence: 99%

Role of Licochalcone A in Potential Pharmacological Therapy: A Review

Xie

Jiang

et al. 2022

Front. Pharmacol.

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Licochalcone A (LA), a useful and valuable flavonoid, is isolated from Glycyrrhiza uralensis Fisch. ex DC. and widely used clinically in traditional Chinese medicine. We systematically updated the latest information on the pharmacology of LA over the past decade from several authoritative internet databases, including Web of Science, Elsevier, Europe PMC, Wiley Online Library, and PubMed. A combination of keywords containing “Licochalcone A,” “Flavonoid,” and “Pharmacological Therapy” was used to help ensure a comprehensive review. Collected information demonstrates a wide range of pharmacological properties for LA, including anticancer, anti-inflammatory, antioxidant, antibacterial, anti-parasitic, bone protection, blood glucose and lipid regulation, neuroprotection, and skin protection. LA activity is mediated through several signaling pathways, such as PI3K/Akt/mTOR, P53, NF-κB, and P38. Caspase-3 apoptosis, MAPK inflammatory, and Nrf2 oxidative stress signaling pathways are also involved with multiple therapeutic targets, such as TNF-α, VEGF, Fas, FasL, PI3K, AKT, and caspases. Recent studies mainly focus on the anticancer properties of LA, which suggests that the pharmacology of other aspects of LA will need additional study. At the end of this review, current challenges and future research directions on LA are discussed. This review is divided into three parts based on the pharmacological effects of LA for the convenience of readers. We anticipate that this review will inspire further research.

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“…Pharmacological Activities of Chalcones: The biological effects of chalcones were found to be dependent on the presence, the number and position of functional groups such as methoxy, glycosides, hydroxyl, halogens in both A and B rings 75 . They present a broad spectrum of biological activities such as antifungal 76 , antifilarial, larvicidal, anticonvulsant 66 , anticancer 77,78 , antiinflammatory 79 , neuroprotective 79 , antimalarial 80 , antibacterial 81 , antilipidemic 82 , antihyperglycemic 82 , antiviral 83 , antimycobacterial 84 , antiprotozoal (antileishmanial and antitrypanosoma) 85 , antiangiogenic 86 , antiplatelet 87 , anti-HIV 88 and Two chalconoids from the desert plant Pulicaria incisa prevented cell death by inhibiting reactive oxygen species (ROS) 89 . The chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A.…”

Section: Fig 3: Pharmacological Activities Of Chalconementioning

confidence: 99%

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2020

IJPSR

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Plants are a valuable source of secondary metabolites. Many phytochemicals are obtained from the plant sources that are used as valuable medicinal agents. Chalcones are one of the important secondary metabolites obtained from many edible plants like foods, vegetables, tea, spices and natural foodstuffs. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumulate to an appreciable degree in most plants. Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family that possess a wide variety of cytoprotective and modulatory functions, which may have therapeutic potential for multiple diseases. The largest number of natural chalcones has been isolated from species of the Leguminosae, Asteraceae and Moraceae families. Chalcone accumulating plants have often been used in traditional medicine and These chalcones and their derivatives have shown important antimicrobial, antifungal, anti-mycobacterial, antimalarial, antiviral, antiinflammatory, antioxidant, anti-tumor, antileishmanial, anticancer properties. The purpose of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants and to describe the recent efforts of scientists in a pharmacological screening of chalcones, studying importance of chalcones and their biological activities. INTRODUCTION: Chalcones are a group of phenolic or flavonoid compounds widely distributed in plant kingdom 1. They are both intermediates and end products in flavonoid synthesis, act as defensive compounds, participated in pathogens interactions and contribute to the medicinal value of herbs 2. Naturally occurring chalcones and their synthetic derivatives show a wide spectrum of biological activities 3. For these reasons, chalcones are an object of continuously growing interest amongst scientists 4 .

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Licochalcone A exerts antitumor activity in bladder cancer cell lines and mice models

Cited by 24 publications

References 18 publications

Anticancer effects of licochalcones: A review of the mechanisms

Anticancer effects of licochalcones: A review of the mechanisms

Role of Licochalcone A in Potential Pharmacological Therapy: A Review

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