Licorice: A Potential Herb in Overcoming SARS-CoV-2 Infections

Ng, Swee Li; Khaw, Kooi Yeong; Ong, Yong Sze; Goh, Hui Poh; Kifli, Nurolaini; Teh, Siew Phooi; Ming, Long Chiau; Kotra, Vijay; Goh, Bey Hing

doi:10.1177/2515690x21996662

Cited by 26 publications

(19 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, glabridin also effectively inhibited SARS-CoV-2 at the entry treatment in our study. Other investigators confirmed that glycyrrhizin and licorice extracts overcome SARS-CoV-2 infection [ 41 , 42 ]. The molecular docking study indicated licorice active compounds such as glycyrrhizic acid, liquiritigenin and glabridin against main protease of SARS-CoV-2.…”

Section: Discussionmentioning

confidence: 81%

The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro

et al. 2022

View full text Add to dashboard Cite

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in 2019 has led to a global health crisis. Mutations of the SARS-CoV-2 genome have impeded the development of effective therapeutics and vaccines against SARS-CoV-2. Natural products are important for discovering therapeutics to treat the 2019 coronavirus disease (COVID-19). In the present study, we investigated the antiviral activity of herbal drug extracts from Polygala Root, Areca, and Quercus Bark and natural compounds derived from herbal drug such as baicalin and glabridin, with IC 50 values of 9.5 µg/ml, 1.2 µg/ml, 5.4 µg/ml, 8.8 µM, and 2.5 µM, respectively, against SARS CoV-2 infection in vitro. Certain herbal drug extracts and natural compounds were found to inhibit viral RNA levels and infectious titers of SARS-CoV-2 in a dose-dependent manner. Furthermore, viral protein analyses showed that herbal drug extracts and natural compounds effectively inhibited SARS-CoV-2 in the various entry treatments. Our study revealed that three herbal drugs are good candidates for further in vivo and clinical studies. Supplementary Information The online version contains supplementary material available at 10.1007/s11418-021-01596-w.

show abstract

Section: Discussionmentioning

confidence: 81%

The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro

et al. 2022

View full text Add to dashboard Cite

show abstract

“…For example, the molecular docking and network pharmacology approach confirmed that licorice glycoside E can inhibit 3CLpro to block SARS-CoV-2 replication by targeting phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PIK3CG) and E2F transcription factor 1 (E2F1) through the PI3K-Akt signaling pathway [ 87 , 88 ]. Furthermore, licorice phenol in Huashi Baidu decoction can bind to Mpro and ACE2, which could hinder SARS-CoV-2 replication and block viral binding sites [89] . Glycyrrhizin, a main compound of licorice, has been reported to have antiviral effects on SARS-associated coronaviruses (CoVs), human immunodeficiency virus type 1 (HIV-1), and chronic hepatitis C virus [ 90 , 91 ].…”

Section: Possible Therapeutic Effects Of the Herbs In Jshd For Covid-19 Treatmentmentioning

confidence: 99%

Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms

Tseng

Lee

et al. 2022

Pharmacological Research - Modern Chinese Medicine

View full text Add to dashboard Cite

Background : SARS-CoV-2 has led to a sharp increase in the number of hospitalizations and deaths from pneumonia and multiorgan disease worldwide; therefore, SARS-CoV-2 has become a global health problem. Supportive therapies remain the mainstay treatments against COVID-19, such as oxygen inhalation, antiviral drugs, and antibiotics. Traditional Chinese medicine (TCM) has been shown clinically to relieve the symptoms of COVID-19 infection, and TCMs can affect the pathogenesis of SARS-CoV-2 infection in vitro . Jing Si Herbal Drink (JSHD), an eight herb formula jointly developed by Tzu Chi University and Tzu Chi Hospital, has shown potential as an adjuvant treatment for COVID-19 infection. A randomized controlled trial (RCT) of JSHD as an adjuvant treatment in patients with COVID-19 infection is underway Objectives : This article aims to explore the efficacy of the herbs in JSHD against COVID-19 infection from a mechanistic standpoint and provide a reference for the rational utilization of JSHD in the treatment of COVID-19. Method : We compiled evidence of the herbs in JSHD to treat COVID-19 in vivo and in vitro . Results : We described the efficacy and mechanism of action of the active ingredients in JSHD to treat COVID-19 based on experimental evidence. JSHD includes 5 antiviral herbs, 7 antioxidant herbs, and 7 anti-inflammatory herbs. In addition, 2 herbs inhibit the overactive immune system, 1 herb reduces cell apoptosis, and 1 herb possesses antithrombotic ability. Conclusion : Although experimental data have confirmed that the ingredients in JSHD are effective against COVID-19, more rigorously designed studies are required to confirm the efficacy and safety of JSHD as a COVID-19 treatment.

show abstract

“…The active metabolites of licorice such as glycyrrhizin may inhibit the binding of S protein to ACE2 receptor and reduce viral entry (Bailly & Vergoten, 2020), but the exact mechanism is still unknown. Subsequently, they also inhibited the catalytic activity of 3C like protease, essential for viral replication and assembly in the host cell (Ng et al, 2021) (Figure 7).…”

Section: F I G U R Ementioning

confidence: 99%

A review on phytochemicals, pharmacological activities, drug interactions, and associated toxicities of licorice (Glycyrrhizasp.)

et al. 2021

View full text Add to dashboard Cite

Since the beginning, human beings have consistently been using plants and their components for the prevention and treatment of various ailments. However, in the last few decades, plant-based medicines and health supplements are gaining more acceptability and rapid popularity. Licorice (Glycyrrhiza sp.) is a terrestrial herb belonging to the family Fabaceae and primarily cultivated in European, Middle Eastern, and South Asian countries. Ethnomedicinal uses of licorice have frequently been described in the world's renowned medical systems, including Ayurveda, Unani, Chinese, Korean, Japanese, African, and European traditional medical systems. To date, 30 species of licorice are known, and among them, G. glabra, G. inflata, and G. uralensis are significantly explored for nutritional and pharmacological benefits. The wide range of commercially available products, including herbal preparations, health supplements, cosmetics, and food and feeds preparations use licorice as active ingredient. Glabridin, licochalcone A, glycyrrhizin, and 18-glycyrrhetinic acid are the notable phytochemicals isolated from licorice and immensely explored for biological and pharmacological activities. Nevertheless, the excessive intake of licorice has also been associated with a wide spectrum of adverse effects on human health. Among them, several are reported to be mediated by modulation of drug-metabolizing cytochrome P-450 enzymes. In the present review, we provide a comprehensive description of the current knowledge of licorice, including historical development, phytoconstituents, species-specific marker metabolites, herb-drug interaction, pharmacological uses, food additive application, and toxicities. We believe this review will provide excellent information to physicians, researchers, and personnel of different scientific regulatory bodies.

show abstract

Licorice: A Potential Herb in Overcoming SARS-CoV-2 Infections

Cited by 26 publications

References 31 publications

The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro

The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro

Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms

A review on phytochemicals, pharmacological activities, drug interactions, and associated toxicities of licorice (Glycyrrhizasp.)

Contact Info

Product

Resources

About