Licorice Ameliorates Postural Hypotension Caused by Diabetic Autonomic Neuropathy

Basso, Alessia; Paola, Luca Dalla; Erle, G; Boscaro, Marco; Armanini, Decio

doi:10.2337/diacare.17.11.1356

Cited by 20 publications

(13 citation statements)

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“…Fernie (1897) suggests that the sugar of licorice is safe for diabetics. A positive effect of licorice in postural hypotension has been reported in autonomic diabetic neuropathy (Basso et al, 1994).…”

Section: Other Miscellaneous Endocrine Effectsmentioning

confidence: 91%

History of The Endocrine Effects of Licorice

Armanini¹,

Fiore²,

Mattarello³

et al. 2002

Exp Clin Endocrinol Diabetes

159

116

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The history of licorice as an officinal plant dates back thousands of years, and licorice is still appreciated as a medicinal root. Many of its endocrine properties can be derived from observations of Authors of the ancient world, when hormones were not known. Inappropriate use of licorice can produce pseudoaldosteronism, by inactivating 11beta-hydroxysteroiod-dehydrogenase and by binding to mineralocorticoid receptors. Licorice possesses many other therapeutic properties as to potentiate the action of cortisol, to reduce testosterone synthesis, especially in women, to exert an estrogen-like activity and to reduce body fat mass. The chronological development of research on these effects is described.

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Section: Other Miscellaneous Endocrine Effectsmentioning

confidence: 91%

History of The Endocrine Effects of Licorice

Armanini¹,

Fiore²,

Mattarello³

et al. 2002

Exp Clin Endocrinol Diabetes

159

116

View full text Add to dashboard Cite

show abstract

“…Pyridostigmine, an acetylcholinesterase inhibitor, is also an increasingly accepted option as it improves sympathetic ganglionic transmission and thereby enhances vascular tone without exacerbating supine hypertension. 78 At least one anecdotal report 79 suggests that glycyrrhizic acid-containing preparations (licorice) may relieve symptoms of postural hypotension caused by diabetic autonomic neuropathy. Additionally, pacemakers can be used to treat OH in patients with bradycardia.…”

Section: Treatmentmentioning

confidence: 99%

A Review of the Etiology, Asssociated Comorbidities, and Treatment of Orthostatic Hypotension

Perlmuter

Sarda²,

Casavant³

et al. 2013

American Journal of Therapeutics

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The magnitude of increase in systolic blood pressure in response to the shift from supine to upright posture is considered to reflect the adequacy of orthostatic regulation. Orthostatic integrity is largely maintained by the interaction between the skeletal muscle pump, neurovascular compensation, neurohumoral effects, and cerebral blood flow regulation. Various physiological states and disease conditions may disrupt these mechanisms as seen in vasovagal syncope, dysautonomic orthostatic intolerance, and postural orthostatic tachycardia syndrome. Orthostatic hypotension (OH) and decreased cerebral blood flow are strongly related. Even subclinical OH has been associated to different degrees with impaired cognitive function, decreased effort, reduced motivation, increased hopelessness, and signs of attention-deficit hyperactivity disorder and dementia, diabetes mellitus, and Parkinson disease. Furthermore, subclinical levels of inadequate blood pressure regulation in response to orthostasis have been linked to increased depression and anxiety and intergenerational behavioral sequelae between mother and child. Identifying causes of subclinical and clinical OH is critical in improving quality of life for both children and older adults. A better understanding of the underlying causes responsible for the etiology of OH could lead to a rational design of novel effective therapeutic regimens for the treatment of this condition and associated comorbidities.

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“…Their efficacy to treat recurrent aphthous stomatitis, postextubation sore throat, gastrointestinal and skin disorders, cancer, and hepatitis B and C have been evaluated in clinical studies (Nassiri Asl and Hosseinzadeh, ; Hosseinzadeh and Nassiri Asl, ). Licorice could be used in patients with postural hypotension attributable to autonomic diabetic neuropathy (Basso et al ., ) and hirsutism and polycystic ovary syndrome (Armanini et al ., ). The efficacy of licorice in combination with Cinnamomum verum , Hypericum perforatum , Paeonia lactiflora , Tribulus terrestris , and lifestyle intervention has been proved in women with polycystic ovary syndrome (Arentz et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review

Nazari

Rameshrad

Hosseinzadeh

2017

Phytotherapy Research

211

110

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Licorice (Glycyrrhiza glabra) has been considered as an herbal drug since ancient time. Nowadays, it is a well-known spice that possesses worth pharmacological effects. However, some relevant articles have revealed negative impacts of licorice in health. By considering the great wishes in using herbal medicine, it is important to show adverse effects of herbal medicine in health. At present, there are misunderstandings toward the safety of herbal medicines. Herein, we gathered scientific research projects on the toxicity effects of licorice and glycyrrhizin to highlight their safety. In this regards, we categorized our findings about the toxicity effects of licorice and glycyrrhizin in acute, sub-acute, sub-chronic, and chronic states. Besides, we discussed on the cytotoxicity, genotoxicity, mutagenicity, and carcinogenicity of licorice and glycyrrhizin as well as their developmental toxicity. This review disclosed that G. glabra and glycyrrhizin salts are moderately toxic. They need to be used with caution during pregnancy. G. glabra and glycyrrhizin possess selective cytotoxic effects on cancerous cells. The most important side effects of licorice and glycyrrhizin are hypertension and hypokalemic-induced secondary disorders. Licorice side effects are increased by hypokalemia, prolonged gastrointestinal transient time, decreased type 2 11-beta-hydroxysteroid dehydrogenase activities, hypertension, anorexia nervosa, old age, and female sex. Copyright © 2017 John Wiley & Sons, Ltd.

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Licorice Ameliorates Postural Hypotension Caused by Diabetic Autonomic Neuropathy

Cited by 20 publications

References 0 publications

History of The Endocrine Effects of Licorice

History of The Endocrine Effects of Licorice

A Review of the Etiology, Asssociated Comorbidities, and Treatment of Orthostatic Hypotension

Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review

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