Licorice extract increases cyclophosphamide teratogenicity by upregulating the expression of cytochrome P‐450 2B mRNA

Park, Dongsun; Yang, Yaewon; Choi, Ehn‐Kyoung; Yang, Goeun; Bae, Dae-Kwon; Lee, Sun Hee; Kim, Tae Kyun; Kyung, Jangbeen; Kim, Dajeong; Choi, Kyung‐Chul; Kim, Yun-Bae

doi:10.1002/bdrb.20327

Cited by 13 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we found that licorice extract improved the fertilizing ability of BALB/cA mouse sperm in vitro and that the fertilized eggs developed normally. It was reported that licorice extract increased cyclophosphamide teratogenicity and upregulated the mRNA expression of cytochrome P-450 2B in rats [10]. These results indicate that licorice root contains multiple components with biological activity.…”

Section: Discussionmentioning

confidence: 62%

Improved In Vitro Fertilization Ability of Mouse Sperm Caused by the Addition of Licorice Extract to the Preincubation Medium

Tung¹,

Shoyama²,

Wada³

et al. 2014

TORSJ

View full text Add to dashboard Cite

Artificial fertilization is used for the stable production of domestic animals, conservation of rare animals, and infertility treatment. However, the success rate of artificial fertilization is limited; thus, a more effective approach is desired. Cattle workers in Japan often add licorice grass to the herbage given to their animals before performing artificial insemination in an effort to increase the pregnancy rate. To examine the effects of licorice on fertilization success in mice, an aqueous extract of licorice was added to the culture medium used for insemination. The results were compared to those using glycyrrhizin, a major active constituent of licorice. The fertilization rate was improved by the aqueous licorice extract, but not specifically by glycyrrhizin. Thus, flavonoids in licorice other than glycyrrhizin may improve the success rate of artificial fertilization.

show abstract

Section: Discussionmentioning

confidence: 62%

Improved In Vitro Fertilization Ability of Mouse Sperm Caused by the Addition of Licorice Extract to the Preincubation Medium

Tung¹,

Shoyama²,

Wada³

et al. 2014

TORSJ

View full text Add to dashboard Cite

show abstract

“…Park et al reported that licorice extract increased cyclophosphamide teratogenicity and upregulated the mRNA expression of cytochrome P-450 2B in rats [29]. The results suggest that licorice root contains various bioactive components.…”

Section: In Vitro Fertilization Of Mouse Sperm By Licorice Crude Extrmentioning

confidence: 95%

In Vitro Fertilization Activators for Future

Tanaka¹,

Wada²,

Tung³

et al. 2017

Biological Activities and Action Mechanisms of Licorice Ingredients

View full text Add to dashboard Cite

Artificial insemination is an indispensable technology for cattle breeding and is used for treating infertility in humans. Thus, new or improved methods are needed to increase the efficiency of artificial insemination. In vitro fertilization (IVF) has been developed in mice. Although many mouse lines produced using IVF have been preserved by freezing embryos and/or fertilized eggs, the more efficient IVF using freezing preservation or long-term refrigeration of sperm is expected to preserve mouse lines more easily. In this chapter, we introduce the active compounds in licorice to improve the rate of IVF. We previously reported that the rate of IVF in mice was improved by adding a water extract of licorice (Glycyrrhiza uralensis), but not glycyrrhizin, to the artificial insemination culture medium. Recently, we analyzed the active ethyl acetate fraction containing high levels of flavonoids. This fraction was further purified by bioassay-guided separation to isolate isoliquiritigenin and formononetin, which contributed to the improved rate of IVF. Isoliquiritigenin and formononetin may be useful therapeutic agents for infertility treatment.

show abstract

“…It has been shown that G. uralensis increases cyclophosphamide teratogenicity potential due to induction of CYP 2B activity (Park et al ., ). This pharmacokinetic interaction should be noticed for G. glabra owing to its inducing effects on CYP isoenzymes.…”

Section: Licorice and Glycyrrhizin‐related Drug Interactionmentioning

confidence: 97%

Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review

Nazari

Rameshrad

Hosseinzadeh

2017

Phytotherapy Research

211

110

View full text Add to dashboard Cite

Licorice (Glycyrrhiza glabra) has been considered as an herbal drug since ancient time. Nowadays, it is a well-known spice that possesses worth pharmacological effects. However, some relevant articles have revealed negative impacts of licorice in health. By considering the great wishes in using herbal medicine, it is important to show adverse effects of herbal medicine in health. At present, there are misunderstandings toward the safety of herbal medicines. Herein, we gathered scientific research projects on the toxicity effects of licorice and glycyrrhizin to highlight their safety. In this regards, we categorized our findings about the toxicity effects of licorice and glycyrrhizin in acute, sub-acute, sub-chronic, and chronic states. Besides, we discussed on the cytotoxicity, genotoxicity, mutagenicity, and carcinogenicity of licorice and glycyrrhizin as well as their developmental toxicity. This review disclosed that G. glabra and glycyrrhizin salts are moderately toxic. They need to be used with caution during pregnancy. G. glabra and glycyrrhizin possess selective cytotoxic effects on cancerous cells. The most important side effects of licorice and glycyrrhizin are hypertension and hypokalemic-induced secondary disorders. Licorice side effects are increased by hypokalemia, prolonged gastrointestinal transient time, decreased type 2 11-beta-hydroxysteroid dehydrogenase activities, hypertension, anorexia nervosa, old age, and female sex. Copyright © 2017 John Wiley & Sons, Ltd.

show abstract

Licorice extract increases cyclophosphamide teratogenicity by upregulating the expression of cytochrome P‐450 2B mRNA

Abstract: The results indicate that repeated intake of licorice may aggravate cyclophosphamide-induced body weight loss and malformations of fetuses by upregulating CYP2B.

Cited by 13 publications

References 32 publications

Improved In Vitro Fertilization Ability of Mouse Sperm Caused by the Addition of Licorice Extract to the Preincubation Medium

Improved In Vitro Fertilization Ability of Mouse Sperm Caused by the Addition of Licorice Extract to the Preincubation Medium

In Vitro Fertilization Activators for Future

Toxicological Effects of Glycyrrhiza glabra (Licorice): A Review

Contact Info

Product

Resources

About