Lidocaine‐Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo‐Controlled, Double‐Blind, Crossover Study

Aihara, Seishi; Yamada, S.; Shichijo, Satoru; Fukumitsu, Kento; Kondo, Mio; Hirashima, Yutaro; Oka, Hideaki; Kamimura, Taro; Harada, Atsumi; Nakano, Toshiaki; Tsuruya, Kazuhiko; Kitazono, Takanari

doi:10.1111/1744-9987.12813

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…It is indicated as an amide-type local anesthetic that causes sensory nerve block by interfering with the passage of sodium ions through the membrane of nerve cells. It is used to produce local analgesia on normal intact skin or genital mucous membranes for superficial minor surgery after application under occlusive dressing [1].…”

Section: Introductionmentioning

confidence: 99%

Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers

Li,

Cai,

et al. 2023

BMC Pharmacol Toxicol

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Background EMLA cream is a local anesthetic. The pharmacokinetics and dermal effects of a topical anesthetic formulation has not been evaluated in healthy Chinese volunteers. Materials and methods The Pharmacokinetics of the lidocaine/prilocaine test (T) or reference (R, EMLA) cream were evaluated in a fasting, single-dose, two-period crossover bioequivalent study conducted in 40 healthy Chinese volunteers. Meanwhile, the dermal effects including blanching, erythema, temperature sensation, edema, and skin rash were also evaluated during the study. Results After applied 15 g of the cream for 4 h to a 100 cm2 area under plastic occlusive film on the skin of the thigh of healthy volunteers, the results of the pharmacokinetic study showed that the active components absorbed in skin from topical products was relatively low compared with most system absorption drugs. After the removal of the residual anesthetic cream, there was a vascular biphasic response with initial transient blanching which reaches a peak at 4.5 h and later more persisting period erythema. The change of temperature sensory sensitivity reached the peak value at 4.5-6 h.There was no statistically significant difference of the changes after application the lidocaine/prilocaine T or R cream in subjects. In general, the lidocaine/prilocaine T or R cream was well tolerated. Conclusion The method described a model for investigations of pharmacokinetics and pharmacodynamics of topical lidocaine/prilocaine cream. Except the plasma drug level indicator, these pharmacodynamics data should also be evaluated in the anesthetic transdermal pharmacokinetics study. Clinical Trial Registration CTR20211544; registered in http://www.chinadrugtrials.org.cn/ at September 2021.

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Section: Introductionmentioning

confidence: 99%

Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers

Li,

Cai,

et al. 2023

BMC Pharmacol Toxicol

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“…The literature shows that lidocaine preparations and several non-drug measures have positive effects to alleviate AVF puncture pain, including lidocaine formulations that include lidocaine cream [ 12 ], lidocaine spray [ 13 ], or nanoemulsion [ 14 ]. Complementary and alternative medicine (CAM) approaches have been shown to enhance pain relief, including music therapy [ 7 ], aromatherapy [ 10 ], Rose fixed oil [ 15 ], cryotherapy [ 9 ], moxibustion [ 16 ], herb ( Fumaria parviflora L. [ 17 ]), and relaxation training [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Auricular Point Acupressure Combined with Compound Lidocaine Cream to Manage Arteriovenous Fistula Puncture Pain: A Multicenter Randomized Controlled Trial

Wei

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Arteriovenous fistula (AVF) puncture pain is an inevitable problem for maintenance hemodialysis (MHD) patients and may seriously endanger the physical and mental health of patients with MHD. Studies have shown that drug or nondrug measures can reduce AVF puncture pain, but much improvement is needed. When combined with compound lidocaine cream (CLC) in the treatment of AVF puncture pain, auricular point acupressure (APA)—a therapeutic method in which specific points on the auricle of the outer ear are stimulated to treat various disorders of the body—and the therapeutic value and synergistic effects of auriculotherapy merit further investigation. Methods. 120 MHD patients were recruited at blood purification centers in three hospitals between January 2016 and April 2019. After completion of the baseline survey, all patients were randomly divided by the envelope method into a control group, APA group, CLC group, and APA combined with CLC, with 30 subjects per group. The numerical rating scale (NRS) of pain was used to measure the pain before intervention and 1, 4, and 8 weeks after intervention. The State-Trait Anxiety Inventory (STAI), General Comfort Questionnaire (GCQ), blood pressure, and heart rates were obtained before and after the intervention. Results. Pain, anxiety, comfort, blood pressure (BP), and heart rates (HR) of the three groups were better than those of the control group; the difference was statistically significant ( P < 0.05 ). In addition, the APA combined with CLC group was better than the APA group and CLC group, respectively, in those outcomes ( P < 0.05 ). Conclusion. Both APA and CLC can effectively relieve AVF puncture pain, and the combined application has more outstanding effects.

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Pain management with transdermal drug administration: A review

Bian

Zhou³

et al. 2022

International Journal of Pharmaceutics

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Lidocaine‐Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated With Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo‐Controlled, Double‐Blind, Crossover Study

Cited by 5 publications

References 13 publications

Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers

Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers

Auricular Point Acupressure Combined with Compound Lidocaine Cream to Manage Arteriovenous Fistula Puncture Pain: A Multicenter Randomized Controlled Trial

Pain management with transdermal drug administration: A review

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