Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats

Soffritti, Morando; Belpoggi, Fiorella; Tibaldi, Eva; Esposti, Davide Degli; Lauriola, Michelina

doi:10.1289/ehp.10271

Cited by 161 publications

(180 citation statements)

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“…The authors state, based on the results of their study, that aspartame induces cancer in the livers and lungs of male Swiss mice, reiterating their previous conclusions that aspartame is a carcinogenic agent in rodents (Soffritti et al, 2006(Soffritti et al, , 2007. Halldorsson et al (2010) investigated preterm delivery in a cohort of 59 334 pregnant Danish women.…”

Section: Assessment 1 Introductionmentioning

confidence: 94%

“…In its scientific statement, the ANS Panel has indicated that it will undertake a detailed analysis of the study results and conclusions reported by Soffritti et al (2010), including the suggested implication of methanol. ) on a further ERF study investigating the effects of a life-span exposure to low doses of aspartame in rats (Soffritti et al, 2007). This opinion also took into consideration additional data submitted by the Ramazzini Foundation in February 2009.…”

Section: Assessment 1 Introductionmentioning

confidence: 99%

“…The authors reported a dose-related increased incidence of males bearing malignant tumours, an increase in the incidence of lymphomas/leukaemias in males from the high-dose group, a dose-related increase in the incidence of lymphomas/leukaemias in females and a dose-related increased incidence of mammary carcinomas in females. The ANS Panel concluded that, on the basis of all the evidence available, including the data presented in Soffritti et al (2007), there was no indication of any genotoxic or carcinogenic potential of aspartame and no reason to revise the previously established ADI for aspartame of 40 mg/kg body weight/day.…”

Section: Assessment 1 Introductionmentioning

confidence: 99%

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Statement of EFSA on the scientific evaluation of two studies related to the safety of artificial sweeteners

2011

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The European Food Safety Authority was asked to provide scientific advice on two studies, namely a carcinogenicity study in mice (Soffritti et al., 2010) and a prospective cohort study on the association between intakes of artificially sweetened soft drinks and preterm delivery (Halldorsson et al., 2010) and to conclude on the need to revise previous evaluations of aspartame or of the other sweeteners authorised in the European Union. The study by Soffritti et al. (2010) is a long‐term carcinogenicity study in mice with transplacental exposure to the artificial sweetener aspartame. The authors concluded that, based on their results, aspartame induces cancer in the livers and lungs of male Swiss mice. EFSA has evaluated this carcinogenicity study and has concluded that, on the basis of the information available in the publication, the validity of the study and its statistical approach cannot be assessed and that its results cannot be interpreted. Furthermore, in view of the generally recognised lack of relevance for human risk assessment of the type of tumours observed in Swiss mice when they are induced by non‐genotoxic compounds, EFSA concluded that the results presented in Soffritti et al. (2010) do not provide a sufficient basis to reconsider the previous evaluations by EFSA on aspartame. Halldorsson et al. (2010) investigated preterm delivery in a cohort of 59 334 pregnant women. The authors concluded that their results show an association between intake of artificially sweetened soft drinks and preterm delivery in the cohort. EFSA assessed this study and concluded that there is no evidence available to support a causal relationship between the consumption of artificially sweetened soft drinks and preterm delivery and that additional studies are required to reject or confirm an association. Overall, EFSA concluded that the information available from the Soffritti et al. (2010) and Halldorsson et al. (2010) publications do not give reason to reconsider the previous evaluations of aspartame or of other food additive sweeteners authorised in the European Union.

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Section: Assessment 1 Introductionmentioning

confidence: 94%

Section: Assessment 1 Introductionmentioning

confidence: 99%

Section: Assessment 1 Introductionmentioning

confidence: 99%

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Statement of EFSA on the scientific evaluation of two studies related to the safety of artificial sweeteners

2011

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“…The authors state: ''In the last 20 years, the overall incidences of lymphomas/leukemias in [ERF] control rats were reported to be 20.6% (range 8.0-30.9%) among 2,265 male rats and 13.3% (range 4.0-25%) among 2,274 female rats [Soffritti et al, 2007]. Thus, even for lifetime studies, the incidences of lymphomas/ leukemias in the ERF bioassay are relatively low and stable across studies, generally allowing for discernment of treatment-related effects.''…”

Section: To the Editormentioning

confidence: 99%

Comment on “Evaluation of evidence for infection as the mode of action for induction of rat lymphoma” by Caldwell et al. [2008]

Goodman¹,

Beyer²,

Beck³

2008

Environ and Mol Mutagen

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“…Asimismo, el estudio en ratas demostró que la exposición prenatal al aspartame aumenta los efectos carcinogenéticos (Sofritti et al, 2007). Vale la pena señalar que dichos estudios insumen periodos de ensayo que muchas veces exceden la vida del animal, es decir que la manifestación clínica del cáncer que se observa hoy en una persona responde a una exposición al tóxico que data de 20 a 30 años.…”

Section: Introductionunclassified

Edulcorantes naturales

Alonso

2010

lgr

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Natural sweeteners constitute at present, an excellent alternative for their inclusion in the food industry, although this industry has used chemical products like aspartame, aclsufame-k, saccharine, or cyclamate, the harmlessness of these substances has always been in discussion in the main academic food forums, generating bewilderment among low-calorie consumers, even multiple doubts among the regulatory authorities, especially when we speak about consuming these substances for long periods of time. Referring to medicinal plants, some safer sweetener alternatives have been studied in the last years, and at the same time, keep the index of sweetness in suitable levels for the human consumption. Among the most studied we have thaumatin, monellina or steviosides, which are already part of many food products.Keywords: sweeteners, aspartame, thaumatin, steviosides, monellin, sucralose, saccharine. Reseña bibliográfica / ReviewFor ma su ge ri da de ci tar: Alonso, J.R. 2010. Edulcorantes Naturales. La Granja. Vol.12(2). Pp. 3-12. ISSN: 13903799 ResumenLos edulcorantes naturales constituyen, en la actualidad, una excelente alternativa en la industria alimenticia. Si bien esta industria emplea desde hace varios años productos químicos como el aspartame, acelsufame-K, sacarina o ciclamato, la inocuidad de estas sustancias ha estado siempre como tema de discusión en los principales foros académicos alimenticios, generando desconcierto entre los consumidores de productos bajos en calorías, e incluso múltiples dudas entre las propias autoridades regulatorias, en especial cuando se habla del largoplacismo de toma de estas sustancias. En las plantas medicinales se ha investigado en los últimos años alternativas edulcorantes mucho más seguras, y que a la vez, mantengan el índice de dulzor en niveles adecuados para el consumo humano. Entre las sustancias más estudiadas figuran la taumatina, monellina o los esteviósidos, los cuales ya forman parte de muchos productos alimenticios.

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Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats

Cited by 161 publications

References 17 publications

Statement of EFSA on the scientific evaluation of two studies related to the safety of artificial sweeteners

Statement of EFSA on the scientific evaluation of two studies related to the safety of artificial sweeteners

Comment on “Evaluation of evidence for infection as the mode of action for induction of rat lymphoma” by Caldwell et al. [2008]

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