Life Style-Related Diseases of the Digestive System: Endocrine Disruptors Stimulate Lipid Accumulation in Target Cells Related to Metabolic Syndrome

Wada, Koichiro; Sakamoto, Hirotada; Nishikawa, Kenji; Sakuma, Satoru; Nakajima, Atsushi; Fujimoto, Yohko; Kamisaki, Yoshínori

doi:10.1254/jphs.fm0070034

Cited by 88 publications

(58 citation statements)

References 19 publications

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“…Obesity occurs by adipocyte hypertrophy or hyperplasia. Hypertrophy seems to be the initial steps towards adipocyte cell dysfunction (Monteiro, 2009;Monteiro et al, 2006) and POPs action on these mechanisms may promote their dysregulation (Grun and Blumberg, 2009;Wada et al, 2007). Our data did not reveal a correlation between the ΣPOP levels and adipocyte size from the corresponding tissue, probably because we analysed an obese population, and adipocytes are at the limit of lipid accumulation (Tan and Vidal-Puig, 2008;Virtue and Vidal-Puig, 2010).…”

Section: Discussionmentioning

confidence: 54%

Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals—Depot differences and dysmetabolism implications

Pestana

Faria

Sá

et al. 2014

Environmental Research

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A B S T R A C TBackground: The role of persistent organic pollutants (POPs) with endocrine disrupting activity in the aetiology of obesity and other metabolic dysfunctions has been recently highlighted. Adipose tissue (AT) is a common site of POPs accumulation where they can induce adverse effects on human health. Objectives: To evaluate the presence of POPs in human visceral (vAT) and subcutaneous (scAT) adipose tissue in a sample of Portuguese obese patients that underwent bariatric surgery, and assess their putative association with metabolic disruption preoperatively, as well as with subsequent body mass index (BMI) reduction. Methods: AT samples (n¼ 189) from obese patients (BMI Z35) were collected and the levels of 13 POPs were determined by gas chromatography with electroncapture detection (GC-ECD). Anthropometric and biochem-ical data were collected at the time of surgery. BMI variation was evaluated after 12 months and adipocyte size was measured in AT samples. Results: Our data confirm that POPs are pervasive in this obese population (96.3% of detection on both tissues), their abundance increasing with age (RS ¼ 0.310, po0.01) and duration of obesity (RS ¼ 0.170, po0.05). We observed a difference in AT depot POPs storage capability, with higher levels of ΣPOPs in vAT (213.97204.2 compared to 155.17147.4 ng/g of fat, po0.001), extremely relevant when evaluating their metabolic impact. Furthermore, there was a positive correlation between POP levels and the presence of metabolic syndrome components, namely dysglycaemia and hypertension, and more importantly with cardiovascular risk (RS ¼ 0.277, po0.01), with relevance for vAT (RS ¼ 0.315, po0.01). Finally, we observed an interesting relation of higher POP levels with lower weight loss in older patients. Conclusion: Our sample of obese subjects allowed us to highlight the importance of POPs stored in AT on the development of metabolic dysfunction in a context of obesity, shifting the focus to their metabolic effects and not only for their recognition as environmental obesogens.

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Section: Discussionmentioning

confidence: 54%

Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals—Depot differences and dysmetabolism implications

Pestana

Faria

Sá

et al. 2014

Environmental Research

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“…There is a complex relationship between prenatal exposure to oestrogen and offspring weight at maturity [70]. BPA has been found to stimulate lipid accumulation and the differentiation of preadipocytes into mature cells [71]. It seems that PPAR may be a link to explain the molecular mechanisms of EDC impact on the pathogenesis of obesity.…”

Section: Obesitymentioning

confidence: 99%

“…Istnieje zależność pomiędzy prenatalną ekspozycją na estrogeny a masą ciała potomstwa w okresie dojrzałości [70]. Wykazano, że BPA również wykazuje zdolność do stymulacji odkładania lipidów w adipocytach oraz wpływa na dojrzewanie preadipcytów [71]. Wydaje się, że molekularny mechanizm działania EDC poprzez receptory PPAR może tłumaczyć ich negatywną rolę w patogenezie otyłości.…”

Section: Bisfenol a (Bpa) -22-bis(p-hydroksyfenylo) Propanunclassified

Stanowisko Polskiego Towarzystwa Endokrynologicznego dotyczące związków endokrynnie czynnych (EDC)

Rutkowska

Rachoń

Milewicz

et al. 2015

Endokrynologia Polska

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With the reference to the position statements of the Endocrine Society, the Paediatric Endocrine Society, and the European Society of Paediatric Endocrinology, the Polish Society of Endocrinology points out the adverse health effects caused by endocrine disrupting chemicals (EDCs) commonly used in daily life as components of plastics, food containers, pharmaceuticals, and cosmetics. The statement is based on the alarming data about the increase of the prevalence of many endocrine disorders such as: cryptorchidism, precocious puberty in girls and boys, and hormone-dependent cancers (endometrium, breast, prostate). In our opinion, it is of human benefit to conduct epidemiological studies that will enable the estimation of the risk factors of exposure to EDCs and the probability of endocrine disorders. Increasing consumerism and the industrial boom has led to severe pollution of the environment with a corresponding negative impact on human health; thus, there is great necessity for the biomonitoring of EDCs in Poland. StreszczenieW nawiązaniu do opublikowanych ostatnio stanowisk Towarzystwa Endokrynologicznego (Endocrine Society), Towarzystwa Endokrynologii Pediatrycznej (Pediatric Endocrine Society) oraz Europejskiego Towarzystwa Endokrynologii Pediatrycznej (European Society of Pediatric Endocrinology), Polskie Towarzystwo Endokrynologiczne (PTE) zwraca uwagę na negatywne skutki zdrowotne spowodowane ekspozycją na związki endokrynnie czynne (EDC, endocrine disrupting chemicals) używane w przemyśle jako składowe plastików, opakowań żywności, leków oraz kosmetyków. Postępująca urbanizacja, industrializacja i konsumpcjonizm prowadzą do zwiększonego skażenia środowiska, które wpływa negatywnie na organizmy żywe, w tym również na ludzkie zdrowie. Obecnie znanych jest ponad 800 związków, które wykazują zdolność zaburzania czynności układu dokrewnego. Narastająca częstość występowania przypadków zaburzeń endokrynnych, zaburzeń rozwoju narządów płciowych, zaburzeń metabolicznych zwraca szczególną uwagę na potencjalną rolę czynników środowiskowych. Stanowisko PTE zostało sprowokowane alarmującymi danymi o wzroście częstości występowania: zaburzeń płodności, wnętrostwa, przedwczesnego dojrzewania płciowego dziewcząt i chłopców, nowotworów hormonozależnych, w tym raka endometrium, sutka, gruczołu krokowego, jajnika i jąder. W opinii autorów konieczne jest przeprowadzenie w Polsce reprezentatywnych, długoterminowych badań epidemiologicznych pozwalających na ocenę związku pomiędzy ekspozycją na EDC a występowaniem zaburzeń czynności gruczołów wydzielania wewnętrznego. Niezwykle ważne wydaje się stworzenie wielodyscyplinarnej grupy badawczej. Uzyskane wyniki po przedstawieniu przedstawicielom rządu, mogłyby umożliwić wprowadzenie stosownych rozporządzeń prawnych.

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“…Both sex steroids and leptin are involved in early organizational effects in the hypothalamus that affect respectively the central control of reproduction [40 • ] and energy balance [41 • ]. Peripherally, whereas EDC effects on male and female reproductive tract have been extensively described [2 • ], EDCs appeared more recently to cause induction of cell differentiation and adipogenesis [42] as well as lipid accumulation in differentiated adipocytes [43]. Gestational and lactational exposure to BPA resulted in increased adipogenesis at weaning in female rats [44].…”

Section: Endocrine Disruption Of Growth and Development: A Common Earmentioning

confidence: 99%

Early homeostatic disturbances of human growth and maturation by endocrine disrupters

Bourguignon

Parent

2010

Current Opinion in Pediatrics

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Purpose of reviewWe attempt to delineate and integrate aspects of growth and development that could be affected by endocrine disrupters [endocrine-disrupting compounds (EDC)], an increasing public health concern. Recent findingsEpidemiological and experimental data substantiate that fetal and early postnatal life are critical periods of exposure to endocrine disrupters, with possible transgenerational effects. The EDC effects include several disorders of the reproductive system throughout life (abnormalities of sexual differentiation, infertility or subfertility and some neoplasia) and disorders of energy balance (obesity and metabolic syndrome). The mechanisms are consistent with the concept of 'developmental origin of adult disease'. They could involve crosstalk between the factors controlling reproduction and those controlling energy balance, both in the hypothalamus and peripherally. SummaryDue to ubiquity of endocrine disrupters and lifelong stakes of early exposure, individual families should be provided by pediatricians with recommendations following the precautionary principle, that is prevention or attenuation of conditions possibly detrimental to health before the evidence of such adverse effects is complete and undisputable.

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Life Style-Related Diseases of the Digestive System: Endocrine Disruptors Stimulate Lipid Accumulation in Target Cells Related to Metabolic Syndrome

Cited by 88 publications

References 19 publications

Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals—Depot differences and dysmetabolism implications

Persistent organic pollutant levels in human visceral and subcutaneous adipose tissue in obese individuals—Depot differences and dysmetabolism implications

Stanowisko Polskiego Towarzystwa Endokrynologicznego dotyczące związków endokrynnie czynnych (EDC)

Early homeostatic disturbances of human growth and maturation by endocrine disrupters

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