Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

Warmink-Perdijk, Willemijn D.B.; Peters, Lilian L.; Tigchelaar, Ettje F.; Dekens, Jackie; Jankipersadsing, Soesma A; Zhernakova, Alexandra; Bossers, Willem; Sikkema, Jan; Jonge, Ank de; Reijneveld, Sijmen A.; Verkade, Henkjan J.; Koppelman, Gerard H.; Wijmenga, Cisca; Kuipers, Folkert; Scherjon, Sicco A.

doi:10.1007/s10654-020-00614-7

Cited by 24 publications

(22 citation statements)

References 57 publications

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“… 1 Since 2016, LLNEXT has been recruiting an additional generation through inclusion of mother–baby pairs, with partners also invited to participate to generate parent–baby trios. 2 …”

Section: Cohort Descriptionmentioning

confidence: 99%

“…To identify genetic and environmental risk factors for COVID-19 and address the medical, social and psychological impacts of the pandemic, a multidisciplinary group of researchers rapidly developed and implemented an extensive COVID-19 questionnaire, leading to the development of the Lifelines COVID-19 cohort. The questionnaire collects data about COVID-19 related symptoms, current health issues and societal impacts from participants recruited from the Lifelines population cohort 1 and the Lifelines NEXT (LLNEXT) birth cohort, 2 which are both monitoring the health of the northern Dutch population (provinces of Drenthe, Groningen and Friesland). Via a (bi)weekly questionnaire, the project gathers information about COVID-19 symptoms, associated comorbidities and environmental factors, changes in work and employment, COVID-19 related worries, loneliness and the mental health and societal impacts of the pandemic.…”

Section: Introductionmentioning

confidence: 99%

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Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

et al. 2021

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PurposeThe Lifelines COVID-19 cohort was set up to assess the psychological and societal impacts of the COVID-19 pandemic and investigate potential risk factors for COVID-19 within the Lifelines prospective population cohort.ParticipantsParticipants were recruited from the 140 000 eligible participants of Lifelines and the Lifelines NEXT birth cohort, who are all residents of the three northern provinces of the Netherlands. Participants filled out detailed questionnaires about their physical and mental health and experiences on a weekly basis starting in late March 2020, and the cohort consists of everyone who filled in at least one questionnaire in the first 8 weeks of the project.Findings to date>71 000 unique participants responded to the questionnaires at least once during the first 8 weeks, with >22 000 participants responding to seven questionnaires. Compiled questionnaire results are continuously updated and shared with the public through the Corona Barometer website. Early results included a clear signal that younger people living alone were experiencing greater levels of loneliness due to lockdown, and subsequent results showed the easing of anxiety as lockdown was eased in June 2020.Future plansQuestionnaires were sent on a (bi)weekly basis starting in March 2020 and on a monthly basis starting July 2020, with plans for new questionnaire rounds to continue through 2020 and early 2021. Questionnaire frequency can be increased again for subsequent waves of infections. Cohort data will be used to address how the COVID-19 pandemic developed in the northern provinces of the Netherlands, which environmental and genetic risk factors predict disease susceptibility and severity and the psychological and societal impacts of the crisis. Cohort data are linked to the extensive health, lifestyle and sociodemographic data held for these participants by Lifelines, a 30-year project that started in 2006, and to data about participants held in national databases.

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“… 1 Since 2016, LLNEXT has been recruiting an additional generation through inclusion of mother–baby pairs, with partners also invited to participate to generate parent–baby trios. 2 …”

Section: Cohort Descriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

et al. 2021

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“…Lifelines was also designed to recruit multiple participants within families to produce a multi-generational cohort that could map individual and community health across life-course [1]. Since 2016, Lifelines NEXT has been recruiting an additional generation through inclusion of mother-baby pairs, with partners also invited to participate to generate parent-baby trios [2]. In addition, sub-cohorts within Lifelines such as Lifelines DEEP [8] and Lifelines DAG3 have collected much more detailed biological measurements, including genotype, metagenomics, metabolomics and transcriptomics.…”

Section: Methodsmentioning

confidence: 99%

“…Besides linkage to other Lifelines data, the Lifelines COVID-19 cohort data can also be linked to societal data held by Statistics Nederland, to drug prescription data held by IADB.nl via the Pharmlines initiative [22] and to SARS-CoV-2 testing data (including serological data) held by Certe and other Dutch laboratories. Overlap with enriched Lifelines datasets in Lifelines Deep [8], Lifelines DAG3 (an on-going project with metagenomic sequencing the gut microbiome of 10,000 Lifelines participants) and Lifelines NEXT [2] will also allow for research projects with a different scope. Given that there is now genetic data for 17,911 of the 68,501 COVID-19 cohort participants generated through the UMCG Genetics Lifelines Initiative (UGLI), it will be possible to look at genetic risk (and protective) factors.…”

Section: Links To Other National and International Programsmentioning

confidence: 99%

“…To identify genetic and environmental risk factors for COVID-19 and address the medical, social and psychological aspects of the pandemic, we developed and implemented a COVID-19 questionnaire, leading to the development of the Lifelines COVID-19 cohort. The questionnaire collects data about COVID-19–related symptoms, current health issues and societal impacts from participants recruited from the Lifelines population cohort [1] and the Lifelines NEXT birth cohort [2], which both monitor the health of the northern Dutch population.…”

Section: Introductionmentioning

confidence: 99%

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The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

Intyre

Lanting

Deelen

et al. 2020

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The COVID−19 pandemic has affected billions of people around the world not only through the infection itself but also through its wider impact on public health and daily life. To assess the effects of the pandemic, a team of researchers across a wide range of disciplines developed and implemented the Lifelines COVID−19 questionnaire, leading to the development of the Lifelines COVID−19 cohort. This cohort is recruited from participants of the Lifelines prospective population cohort and the Lifelines NEXT birth cohort, and participants were asked to fill out detailed questionnaires about their physical and mental health and experiences on a weekly basis starting in late March of 2020 and on a bi−weekly basis staring in June 2020. The Lifelines region covers the three Northern provinces of the Netherlands−Drenthe, Groningen and Friesland−which together account for about 10% of the Dutch population. To date, >70,000 people have responded to the questionnaires at least once, and the questionnaire program is still ongoing. Data collected by the questionnaires will be used to address four aspects of the outbreak: (1) how the COVID−19 pandemic developed in the three northern provinces of the Netherlands, (2) which environmental risk factors predict disease susceptibility and severity, (3) which genetic risk factors predict disease susceptibility and severity and (4) what are the psychological and societal impacts of the crisis.

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The Impact of Early-Life Exposures on Women’s Reproductive Health in Adulthood

2021

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Purpose of Review To review the effects of early-life, preconception, and prior-generation exposures on reproductive health in women. Recent Findings Women’s early-life factors can affect reproductive health by contributing to health status or exposure level on entering pregnancy. Alternately, they can have permanent effects, regardless of later-life experience. Nutrition, social class, parental smoking, other adverse childhood experiences, environmental pollutants, infectious agents, and racism and discrimination all affect reproductive health, even if experienced in childhood or in utero. Possible transgenerational effects are now being investigated through three- or more-generation studies. These effects occur with mechanisms that may include direct exposure, behavioral, endocrine, inflammatory, and epigenetic pathways. Summary Pregnancy is increasingly understood in a life course perspective, but rigorously testing hypotheses on early-life effects is still difficult. In order to improve the health outcomes of all women, we need to expand our toolkit of methods and theory. Supplementary Information The online version contains supplementary material available at 10.1007/s40471-021-00279-0.

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Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

Cited by 24 publications

References 57 publications

Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

The Impact of Early-Life Exposures on Women’s Reproductive Health in Adulthood

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