Lifestyle and gallstone disease: Scope for primary prevention

Sachdeva, Sandeep; Khan, Zulfia; Ansari, M. Athar; Khalique, Najam; Anees, Afzal

doi:10.4103/0970-0218.91327

Cited by 53 publications

(64 citation statements)

References 16 publications

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“…Case-control study (2)(3)(4)(5) Cross-sectional study (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) Gallstones in pregnancy (21)(22)(23) Letter/editorial/news/note/comment (24)(25)(26)(27)(28)(29)(30) Meta-analysis No protocol Eligibility criteria 6 Specify study characteristics (e.g., PICOS, length of follow-up) and report characteristics (e.g., years considered, language, publication status) used as criteria for eligibility, giving rationale.…”

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confidence: 99%

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Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies

Aune¹,

Leitzmann²,

Vatten³

2016

Journal of Physical Activity and Health

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Background:Physical activity has been hypothesized to reduce the risk of gallbladder disease (gallstones, cholecystitis, cholecystectomy); however, results from epidemiological studies have not always shown statistically significant associations. We conducted a systematic review and meta-analysis to clarify the presence and strength of an association between physical activity and gallbladder disease risk.Methods:PubMed and Embase databases were searched for studies of physical activity and gallbladder disease up to 9th of January 2015. Prospective studies reporting relative risk (RR) estimates and 95% confidence intervals (CIs) of gallbladder disease associated with physical activity were included. Summary RRs were estimated using a random effects model.Results:Eight studies including 6958 cases and 218,204 participants were included. The summary RR for the highest versus the lowest level of physical activity was 0.75 (95% CI: 0.69–0.81, n = 8) and there was no evidence of heterogeneity, I2 = 0%). In the dose-response analysis the summary relative risk per 20 MET-hours of activity was 0.85 (95% CI: 0.80–0.90, I2 = 0%, n = 2) for leisure-time physical activity, 0.83 (95% CI: 0.76–0.90, I2 = 0%, n = 2) for vigorous physical activity, and 0.86 (95% CI: 0.76–0.98, I2 = 0%, n = 2) for nonvigorous physical activity.Conclusion:Our analysis confirms a protective effect of physical activity on risk of gallbladder disease.

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confidence: 99%

“…Search strategy 3 We searched the Pubmed and Embase databases from inception (1966 and 1947, 4 respectively) up to 9 th of January 2015 for eligible studies. As part of a larger project on risk 5 factors for gallbladder disease we used broad search terms in the (Supplementary text).…”

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confidence: 99%

Physical Activity and the Risk of Gallbladder Disease: A Systematic Review and Meta-Analysis of Cohort Studies

Aune¹,

Leitzmann²,

Vatten³

2016

Journal of Physical Activity and Health

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“…Sachdeva et al in their study comprising of 150 patients, also found that hypertension was the commonest associated comorbidity (19%), followed by diabetes mellitus (10%). [25] 26% patients in our study had history of prior abdominal surgery. These figures were similar to those found by Wongworawat et al [26] In their study comprising of 504 patients, 175 patients (34.7%) had undergone prior abdominal surgery.…”

Section: Disscusionmentioning

confidence: 68%

A Prospective Study of 100 Consecutive Laparoscopic Cholecystectomies

Huda¹,

Kumar²,

Singh³

2017

AIMDR

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Background: Cholelithiasis, the leading cause for hospital admissions related to gastrointestinal problems, had been traditionally dealt by open cholecystectomy. Erich Muhe performed the first laparoscopic cholecystectomy on September 12, 1985. In September 1992, a National Institute of Health (NIH) consensus conference held in Bethesda concluded that laparoscopic cholecystectomy should be the treatment of choice for gallstone disease. This study on laparoscopic cholecystectomy was done to illustrate the clinical manifestations and peroperative findings in gallstone disease. Methods: We prospectively studied 100 consecutive cases undergoing laparoscopic cholecystectomy at our institute. Presenting complaints, laboratory investigations and USG findings were noted. Standard 4-port laparoscopic cholecystectomy was performed, with closed method using Veress needle preferred for the first (umbilical) port. All peroperative findings were analyzed. Results: Majority of the patients were female (79%), and the average age of the patients was 40.18 years. Pain in upper abdomen was the most common presenting complaint (93%) and an association with meal was found in 85%. Peroperatively, multiple calculi were found in 77%, with impaction of calculus at neck seen in 10% of the patients. Distended gall bladder was seen in 19%, and mucocele in 3%. Shrunken gall bladder was observed in 4%. Difficult Calot's triangle, due to adhesions, was found in 22%. Biliary tree or vascular anomaly was seen in 8%. Mean postoperative hospital stay was 1.92 days. Conclusion: Pain abdomen in gallstone disease is commonly seen in association with meals. Thick-walled gall bladder, adhesions at Calot's triangle, and distended gall bladder are common peroperative findings.

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“…In a hospital-based case-control study, it was found that significant predictor variables of gallstone disease were abdominal adiposity, inadequate physical activity, and high intake of saturated fats [4]. The authors suggest that the majority of the risk factors are amenable to primary prevention, and screening and surveillance of these risk factors can be incorporated into the primary healthcare system.…”

Section: Introductionmentioning

confidence: 95%