Lifestyle Interventions Improving Cannabinoid Tone During COVID-19 Lockdowns May Enhance Compliance With Preventive Regulations and Decrease Psychophysical Health Complications

Brugnatelli, Viola; Facco, Enrico; Zanette, Gastone

doi:10.3389/fpsyt.2021.565633

Cited by 4 publications

(4 citation statements)

References 102 publications

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“…In agreement with what recently suggested [97], we provide further evidence on the need for strategies aimed to restore ECS homeostasis in order to counteract the effects of SI and avoid the development of psychiatric conditions, also suggesting the importance of an environmental trigger that could be used to revert those epigenetic mechanisms accounting for the alterations observed. Of particular relevance in the last years, it is the possible role played by nutrition on the prevention of mental disorders [98].…”

Section: Discussionsupporting

confidence: 91%

Endocannabinoid system genes regulation in the effects evoked by social isolation in rats

Girella,

Bartolomeo,

Dainese

et al. 2023

Preprint

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Social isolation is a state of lack of social connections, involving the modulation of different molecular signalling cascades and associated with high risk of mental health issues. To investigate if and how gene expression is modulated by social experience at the central level, we analyzed the effects of 5 weeks of social isolation in rats focusing on endocannabinoid system genes transcription in key brain regions involved in emotional control. We observed selective reduction in mRNA levels for fatty acid amide hydrolase (Faah) and cannabinoid receptor type 1 (Cnr1) genes in the amygdala complex and of Cnr1 in the prefrontal cortex of socially isolated rats when compared to controls, and these changes appears to be partially driven by trimethylation of Lysine 27 and acetylation of Lysine 9 at Histone 3. The alterations of Cnr1 transcriptional regulation result also directly correlated with those of oxytocin receptor gene. We here suggest that to counteract the effects of SI, it is of relevance to restore the endocannabinoid system homeostasis via the use of environmental triggers able to revert those epigenetic mechanisms accounting for the alterations observed.

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Section: Discussionsupporting

confidence: 91%

Endocannabinoid system genes regulation in the effects evoked by social isolation in rats

Girella,

Bartolomeo,

Dainese

et al. 2023

Preprint

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“…Endocannabinoid signalling is essential for stress adaptation and can be downregulated in the presence of external stressors causing anxiety and depression, such as domestic burdens, violence or increased workload [53]. The COVID-19 pandemic has led to a worldwide crisis stemming from both the fear of lockdown and the disease itself.…”

Section: Anxiolytic Properties Of Cannabinoidsmentioning

confidence: 99%

“…CBD, a compound with anxiolytic, antidepressant and antipsychotic properties, could prove beneficial in decreasing stress and isolation-induced aggression, as well as help to restore the endocannabinoid homeostasis [53]. Small randomised controlled clinical trials and observational studies proved the potential of CBD in reducing anxiety among various groups of patients [54].…”

Section: Anxiolytic Properties Of Cannabinoidsmentioning

confidence: 99%

Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection

Janecki

Graczyk

Lewandowska

et al. 2022

IJMS

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The COVID-19 pandemic caused by the SARS-CoV-2 virus made it necessary to search for new options for both causal treatment and mitigation of its symptoms. Scientists and researchers around the world are constantly looking for the best therapeutic options. These difficult circumstances have also spurred the re-examination of the potential of natural substances contained in Cannabis sativa L. Cannabinoids, apart from CB1 and CB2 receptors, may act multifacetedly through a number of other receptors, such as the GPR55, TRPV1, PPARs, 5-HT1A, adenosine and glycine receptors. The complex anti-inflammatory and antiviral effects of cannabinoids have been confirmed by interactions with various signaling pathways. Considering the fact that the SARS-CoV-2 virus causes excessive immune response and triggers an inflammatory cascade, and that cannabinoids have the ability to regulate these processes, it can be assumed that they have potential to be used in the treatment of COVID-19. During the pandemic, there were many publications on the subject of COVID-19, which indicate the potential impact of cannabinoids not only on the course of the disease, but also their role in prevention. It is worth noting that the anti-inflammatory and antiviral potential are shown not only by well-known cannabinoids, such as cannabidiol (CBD), but also secondary cannabinoids, such as cannabigerolic acid (CBGA) and terpenes, emphasizing the role of all of the plant’s compounds and the entourage effect. This article presents a narrative review of the current knowledge in this area available in the PubMed, Scopus and Web of Science medical databases.

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“…Multiple studies have investigated stress in HCW utilizing questionnaires, alone or in combination with salivary or hair cortisol/cortisone concentrations, during the COVID-19 pandemic [ 5 , 20 – 25 ]. Because of these important physiological roles of endocannabinoids and endocannabinoid-like compounds in the stress response, in this study we attempted to verify their role relative to the stress impact of the pandemic on HCW.…”

Section: Introductionmentioning

confidence: 99%

Endocannabinoids, endocannabinoid-like compounds and cortisone in head hair of health care workers as markers of stress and resilience during the early COVID-19 pandemic

Biener,

Mueller,

Lin

et al. 2024

Transl Psychiatry

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The pandemic caused by SARS-CoV-2 impacted health systems globally, creating increased workload and mental stress upon health care workers (HCW). During the first pandemic wave (March to May 2020) in southern Germany, we investigated the impact of stress and the resilience to stress in HCW by measuring changes in hair concentrations of endocannabinoids, endocannabinoid-like compounds and cortisone. HCW (n = 178) recruited from multiple occupation and worksites in the LMU-University-Hospital in Munich were interviewed at four interval visits to evaluate mental stress associated with the COVID-19 pandemic. A strand of hair of up to 6 cm in length was sampled once in May 2020, which enabled retrospective individual stress hormone quantifications during that aforementioned time period. Perceived anxiety and impact on mental health were demonstrated to be higher at the beginning of the COVID-19 pandemic and decreased significantly thereafter. Resilience was stable over time, but noted to be lower in women than in men. The concentrations of the endocannabinoid anandamide (AEA) and the structural congeners N-palmitoylethanolamide (PEA), N-oleoylethanolamide (OEA) and N-stearoylethanolamide (SEA) were noted to have decreased significantly over the course of the pandemic. In contrast, the endocannabinoid 2-arachidonoylglycerol (2-AG) levels increased significantly and were found to be higher in nurses, laboratory staff and hospital administration than in physicians. PEA was significantly higher in subjects with a higher resilience but lower in subjects with anxiety. SEA was also noted to be reduced in subjects with anxiety. Nurses had significantly higher cortisone levels than physicians, while female subjects had significant lower cortisone levels than males. Hair samples provided temporal and measurable objective psychophysiological-hormonal information. The hair endocannabinoids/endocannabinoid-like compounds and cortisone correlated to each other and to professions, age and sex quite differentially, relative to specific periods of the COVID-19 pandemic.

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Lifestyle Interventions Improving Cannabinoid Tone During COVID-19 Lockdowns May Enhance Compliance With Preventive Regulations and Decrease Psychophysical Health Complications

Cited by 4 publications

References 102 publications

Endocannabinoid system genes regulation in the effects evoked by social isolation in rats

Endocannabinoid system genes regulation in the effects evoked by social isolation in rats

Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 Infection

Endocannabinoids, endocannabinoid-like compounds and cortisone in head hair of health care workers as markers of stress and resilience during the early COVID-19 pandemic

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