Ligand-dependent complex formation between the Angiotensin II receptor subtype AT2 and Na+/H+ exchanger NHE6 in mammalian cells

Pulakat, Lakshmi; Cooper, Shannon; Knowle, Dieter; Mandavia, Chirag; Bruhl, Steven R.; Hetrick, Mary Michelle; Gavini, Nara

doi:10.1016/j.peptides.2004.12.015

Cited by 30 publications

(16 citation statements)

References 52 publications

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“…The data however indicate that RACK1 regulates the distribution of NHE6 between endosomes and the plasma membrane and thereby contributes to the maintenance of endosomal pH [121]. In addition to RACK1, NHE6 binds to the angiotensin II receptor subtype AT2 in a ligand-dependent manner [138]. Although angiotensin II 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 is known to regulate NHE activity in several cell types, the NHE isoform has remained elusive [123].…”

Section: Slc9a6 -Nhe6mentioning

confidence: 94%

Traditional and emerging roles for the SLC9 Na+/H+ exchangers

Fuster

Alexander

2013

Pflugers Arch - Eur J Physiol

144

122

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The SLC9 gene family encodes Na + /H + exchangers (NHEs). These transmembrane proteins transport ions across lipid bilayers in a diverse array of species from prokaryotes to eukaryotes, including plants, fungi and animals. They utilize the electrochemical gradient of one ion to transport another ion against its electrochemical gradient. Currently, 13 evolutionarily conserved NHE isoforms are known in mammals [46,22,128]. The SLC9 gene family (solute carrier classification of transporters:www.bioparadigms.org) is divided into three subgroups [46]. The SLC9A subgroup encompasses plasmalemmal isoforms NHE1-5 (SLC9A1-5) and the predominantly intracellular isoforms NHE6-9 (SLC9A6-9). The SLC9B subgroup consists of two recently cloned isoforms, NHA1 and NHA2 (SLC9B1 and SLC9B2, respectively). The SLC9C subgroup consist of a sperm specific plasmalemmal NHE (SLC9C1) and a putative NHE, SLC9C2, for which there is currently no functional data [46].NHEs participate in the regulation of cytosolic and organellar pH as well as cell volume. In the intestine and kidney, NHEs are critical for transepithelial movement of Na + and HCO 3 -and thus for whole body volume and acid-base homeostasis [46]. Mutations in the NHE6 or NHE9 genes cause neurological disease in humans and are currently the only NHEs directly linked to human disease.However, it is becoming increasingly apparent that members of this gene family contribute to the pathophysiology of multiple human diseases.

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Section: Slc9a6 -Nhe6mentioning

confidence: 94%

Traditional and emerging roles for the SLC9 Na+/H+ exchangers

Fuster

Alexander

2013

Pflugers Arch - Eur J Physiol

144

122

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“…87 Rat NHE6 was further shown to interact with the G protein coupled receptor AT-2. 88 to osmotic adjustment by ion accumulation inside the vacuole or endosomal compartments. This is also apparent from the observation that the genes are equally induced by salt, KCl or osmotic treatments, and that plant and yeast NHX antiporters also confer resistance to high KCl or hyper-osmotic shock in yeast cells.…”

Section: Function Of Nhx Antiportersmentioning

confidence: 99%

Plant NHX cation/proton antiporters

Rodrı́guez-Rosales

Gálvez

Huertas

et al. 2009

Plant Signaling & Behavior

226

147

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Although physiological and biochemical data since long suggested that Na(+)/H(+) and K(+)/H(+) antiporters are involved in intracellular ion and pH regulation in plants, it has taken a long time to identify genes encoding antiporters that could fulfil these roles. Genome sequencing projects have now shown that plants contain a very large number of putative Cation/Proton antiporters, the function of which is only beginning to be studied. The intracellular NHX transporters constitute the first Cation/Proton exchanger family studied in plants. The founding member, AtNHX1, was identified as an important salt tolerance determinant and suggested to catalyze Na(+) accumulation in vacuoles. It is, however, becoming increasingly clear, that this gene and other members of the family also play crucial roles in pH regulation and K(+) homeostasis, regulating processes from vesicle trafficking and cell expansion to plant development.

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“…This effect could be related to the modulation of renal tubular NHE activities. A recent study demonstrated liganddependent complex formation between the AT 2 receptor and NHE6 [33 ]. This interaction could be responsible for the modulation of NHE6 function.…”

Section: Angiotensin II and Sodium Handlingmentioning

confidence: 93%