Ligand Exchange Chromatography

Davankov, V. A.; Semechkin, A.V.

doi:10.1201/9781351074025

Cited by 33 publications

(16 citation statements)

References 135 publications

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“…Although a limited number of racemates, such as amino acids, are separated by the method, applications of the method to chiral drug analysis are rare. Various aspects of ligand‐exchange chromatography have been reviewed (Davankov, ; Davankov, Navratil, & Walton, ; Davankov & Semechkin, ). The other approach (the indirect one) involves the formation of a covalently bonded diastereomeric pair via the reaction of the racemic analyte with a suitable chiral derivatization reagent (CDR), prior to LC separation step.…”

Section: Introductionmentioning

confidence: 99%

Enantioresolution of (RS)‐baclofen by liquid chromatography: A review

Batra

Bhushan

2016

Biomedical Chromatography

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Baclofen is a commonly used racemic drug and has a simple chemical structure in terms of the presence of only one stereogenic center. Since the desirable pharmacological effect is in only one enantiomer, several possibilities exist for the other enantiomer for evaluation of the disposition of the racemic mixture of the drug. This calls for the development of enantioselective analytical methodology. This review summarizes and evaluates different methods of enantioseparation of (RS)-baclofen using both direct and indirect approaches, application of certain chiral reagents and chiral stationary phases (though very expensive). Methods of separation of diastereomers of (RS)-baclofen prepared with different chiral derivatizing reagents (under microwave irradiation at ease and in less time) on reversed-phase achiral columns or via a ligand exchange approach providing high-sensitivity detection by the relatively less expensive methods of TLC and HPLC are discussed. The methods may be helpful for determination of enantiomers in biological samples and in pharmaceutical formulations for control of enantiomeric purity and can be practiced both in analytical laboratories and industry for routine analysis and R&D activities.

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Section: Introductionmentioning

confidence: 99%

Enantioresolution of (RS)‐baclofen by liquid chromatography: A review

Batra

Bhushan

2016

Biomedical Chromatography

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“…Any compound forming labile coordination complexes with transition elements can be separated by the ligand exchange technique . Due to the high selectivity and complex stabilities, the ligand‐exchange technique has been widely applied in the chromatographic technique . Ligand‐exchange was introduced as a new separation technique by Helfferich .…”

Section: Introductionmentioning

confidence: 99%

“…In this process, ligand represents the analyte undergoes ligand‐exchange. Since its introduction by Davankov and Rogozhin , ligand exchange chromatography has become one of the most promising techniques for both analysis and purification of positional isomers, and nowadays, a great number of researches have emerged regarding different applications of the ligand‐exchange .…”

Section: Introductionmentioning

confidence: 99%

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Ligand Exchange Chromatography of Nitrophenol Positional Isomers on Co‐CMEDA‐Silica Gel

Ayar

2016

CLEAN Soil Air Water

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Nitrophenols are common pollutants detected in industrial effluents because they are used as basic raw materials in various industrial processes. Due to their toxicity to living things they are chemical species that need to be constantly monitored. Hence, the separation of nitrophenol isomers is very important to determine their levels in the environment. Since technical p‐nitrophenol is contaminated with m‐nitrophenol and the other aromatic compounds, the selective separation of p‐nitrophenol from undesired impurities has become one of the important issues of the paracetamol synthesis. In the present work, a new chromatographic method for the separation of nitrophenol isomers on Co(II)‐tris(carboxymethyl)ethylenediamine‐silica gel (Co‐CMEDA‐Silica gel) has been developed using high performance liquid chromatography (HPLC). The chromatographic conditions were optimized by studying the effects of mobile phase composition. The positional isomers of nitrophenol (o‐, m‐, and p‐nitrophenol) could be separated by using ternary mobile phases with water/methanol/acetonitrile in the ratio 5:20:75 under isocratic conditions. The baseline separation of nitrophenol isomers has been achieved successfully with the stepwise gradient elution.

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“…In addition to an improved separation power for amino acids, these phases showed chiral recognition ability for hydroxy acids, dipeptides and barbiturates. A lot of publications appeared in the following on this field [13][14][15][16].…”

Section: Separation By Liquid Chromatographymentioning

confidence: 99%

Chiral Separation by Ligand Exchange

Gbitz¹,

Schmid²

2006

Chiral Separation Techniques

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The principle of chiral ligand-exchange, introduced by Davankov, has become a widely used technique for chiral separation in both chromatography and in electromigration techniques. This simple technique makes use of the formation of mixed metal chelate complexes between a chiral selector and both enantiomers of an analyte. In HPLC, the chiral selector can be either bonded to the stationary phase or added to the mobile phase. In CE the chiral selector is simply added to the electrolyte. A relatively new approach represents CEC, where capillaries contain a chiral stationary phase. More than thousand papers appeared in the field of chiral ligand-exchange. To cite all papers would require several books.The present article gives an overview of both milestones and our activities on chiral separation using the principle of ligand-exchange. Recent advances in chip technology for chiral separations and new approaches regarding improvement of detection sensitivity are mentioned.Keywords: ligand-exchange; chiral selectors; chemically bonded phases; dynamically coated phases; monolithic phases; HPLC; capillary electrophoresis; capillary electro chromatography ХИРАЛНИ РАЗДВОЈУВАЊА СО ИЗМЕНА НА ЛИГАНДИПринципот на измена на лиганди, воведен од Даванков, стана широко користена техника за хирални раздвојувања и во хроматографските и во електромиграциските техники. Оваа едноставна техника го користи образувањето на мешани металoхелатни комплекси помеѓу хирален селектор и обата енантиомерa на аналитот. Во високоефикасната течна хроматографија (HPLC) хиралниот селектор може да биде врзан на стационарната фаза или додаден во мобилната фаза. Во капиларната електрофореза (CE) хиралниот селектор едноставно се додава во електролитот. Капиларната електрохроматографија (CEC) претставува релативно нов пристап, каде што капиларите содржат хирална стационарна фаза. Објавени се повеќе од илјада трудови од областа на хирални раздвојувања со измена на лиганди и потребни би биле повеќе книги за сите тие да се соберат.Во овој труд е даден преглед на главните развојни точки и на нашата работа на хирални разделувања со употреба на принципот на измена на лиганди. Освен тоа, наведени се и последните достигнувања на чип-технологијата за хирални раздвојувања и новите пристапи поврзани со подобрување на осетливоста на детекцијата.Клучни зборови: измена на лиганди; хирални селектори; хемиски врзани фази; динамички нанесени фази; монолитни фази; HPLC; капиларна електрофореза; капиларна електрохроматографија MJCCA9 -576

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Ligand Exchange Chromatography

Cited by 33 publications

References 135 publications

Enantioresolution of (RS)‐baclofen by liquid chromatography: A review

Enantioresolution of (RS)‐baclofen by liquid chromatography: A review

Ligand Exchange Chromatography of Nitrophenol Positional Isomers on Co‐CMEDA‐Silica Gel

Chiral Separation by Ligand Exchange

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