Ligand–Receptor Interactions and Their Implications in Delivering Certain Signaling for Bone Regeneration

Katagiri, Takenobu; Tsukamoto, Sho; Osawa, Kenji; Kokabu, Shoichiro

doi:10.1007/978-3-319-13266-2_1

Cited by 3 publications

(1 citation statement)

References 74 publications

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“…Moreover, anionic sulphated polysaccharides such as heparin (HEP, basal isoelectric point 3.5-4) and dextran sulphate (DS, basal isoelectric point 4-5) can be used as counter polyelectrolytes to enhance the activity of GFs by protecting their ligands. 28 For these reasons, developing a growth factor delivery system using a highly optimized LBL assembly process would provide highly promising loading capacity and tunable controlled release beneficial for various biomedical applications. Here we report the development, optimisation, and evaluation of an LBL assembly technique to incorporate a high concentration of GFs, specifically TGF-β1, PDGF-ββ, and IGF-1, into surface-activated polymeric implants.…”

Section: Introductionmentioning

confidence: 99%

Sustained delivery of growth factors with high loading efficiency in a layer by layer assembly

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Sustained delivery of growth factors with high loading efficiency in a layer by layer assembly

et al. 2020

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Nutritional properties and plausible benefits of Pearl millet (Pennisetum glaucum) on bone metabolism and osteoimmunology : a mini-review

Nani

Belarbi

Khan

et al. 2020

Nor. Afr. J. Food Nutr. Res.

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Bone is a hard connective tissue that undergoes a systematic renewal. This highly dynamic organ is made up of four different types of cells, however, bone formation is commonly attributed to osteoblasts and bone resorption to osteoclasts. Bone tissue formation occurs during embryonic development and in certain post-birth pathological conditions. The immune system could influence the functions of bone cells, and the crosstalk between hematopoietic, immune, and bone cells is known as osteoimmunology. Indeed, cytokines produced by immune cells, including TNF-α and IL-6, are critically implicated in bone pathogenesis. It is well established that diet plays an important role in bone health and function. Indeed, an antioxidant nutraceuticals-rich diet, of which pearl millet is one, can be effective in treating osteoporosis. Pearl millet (PM) is an African native cereal that constitutes the staple food for African Sahel region inhabitants as well as for many peoples in rural regions in India. Pearl millet grains’ content in amino acids, minerals, and phytochemicals may contribute to promoting bone health and metabolism. Accordingly, in the current review, we discuss the putative effects of PM nutrients, with a focus on polyphenols, bone metabolism and osteoimmunology. In the light of our previous studies and others from the literature, we suggest that PM whole grains can be effective in the prevention and management of bone pathogenesis. Keywords: PM whole grains, nutrients, polyphenols, osteoblasts, osteoclasts, osteoimmunology, TNF-α.

show abstract

Nutritional properties and plausible benefits of Pearl millet (Pennisetum glaucum) on bone metabolism and osteoimmunology : a mini-review

Nani

Belarbi

Khan

et al. 2020

Nor. Afr. J. Food Nutr. Res.

View full text Add to dashboard Cite

Bone is a hard connective tissue that undergoes a systematic renewal. This highly dynamic organ is made up of four different types of cells, however, bone formation is commonly attributed to osteoblasts and bone resorption to osteoclasts. Bone tissue formation occurs during embryonic development and in certain post-birth pathological conditions. The immune system could influence the functions of bone cells, and the crosstalk between hematopoietic, immune, and bone cells is known as osteoimmunology. Indeed, cytokines produced by immune cells, including TNF-α and IL-6, are critically implicated in bone pathogenesis. It is well established that diet plays an important role in bone health and function. Indeed, antioxidant nutraceuticals-rich diet, of which pearl millet is one, can be effective in treating osteoporosis. Pearl millet (PM) is an African native cereal that constitutes the staple food for African Sahel region inhabitants as well as for many peoples in rural regions in India. Pearl millet grains content in amino acids, minerals, and phytochemicals may contribute to promoting bone health and metabolism. Accordingly, in the current review, we discuss the putative effects of PM nutrients, with a focus on polyphenols, on bone metabolism and osteoimmunology. In the light of our previous studies and others from literature, we speculate that PM whole grains may be effective in the prevention and management of bone pathogenesis. Keywords: PM whole grains, polyphenols, osteoblasts, osteoclasts, osteoimmunology, TNF-α.

show abstract

Ligand–Receptor Interactions and Their Implications in Delivering Certain Signaling for Bone Regeneration

Cited by 3 publications

References 74 publications

Sustained delivery of growth factors with high loading efficiency in a layer by layer assembly

Sustained delivery of growth factors with high loading efficiency in a layer by layer assembly

Nutritional properties and plausible benefits of Pearl millet (Pennisetum glaucum) on bone metabolism and osteoimmunology : a mini-review

Nutritional properties and plausible benefits of Pearl millet (Pennisetum glaucum) on bone metabolism and osteoimmunology : a mini-review

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