Abstract:Leukocytes interact physically with other cells using cell surface receptors. The largest group of such receptors are non-catalytic tyrosine phosphorylated receptors (NTRs), also called immunoreceptors. Although NTRs have structurally diverse extracellular domains, they signal by a shared mechanism, involving phosphorylation of cytoplasmic tyrosine residues by SRC-family tyrosine kinases. How ligand binding to NTRs induces this phosphorylation, also called NTR triggering, remains controversial, with roles sugg… Show more
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