Light and drug distribution with topically administered photosensitizers

Svaasand, Lars O.; Tromberg, Bruce J.; Wyss, P.; Wyss-Desserich, Marie-Therese; Tadir, Yona; Berns, Michael W.

doi:10.1007/bf02134917

Cited by 33 publications

(20 citation statements)

References 8 publications

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“…The absorption of the treatment light at 633 nm is relatively low, which indicates that the treatment effects can be reached to a depth of more than 3 mm [17]. The slow penetration of ALA into the tissue; yielding an uneven distribution of PpIX has therefore been considered the most important limiting factor in achieving better ALA-PDT results in thick BCCs.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified δ-aminolevulinic acid

Thompson

Gustafsson

Pålsson

et al. 2001

J. Porphyrins Phthalocyanines

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ABSTRACT:Various optical techniques were used to investigate relevant parameters involved in photodynamic therapy (PDT) of human basal cell carcinomas (BCCs). The aim of the study was to compare the diagnostic and therapeutic outcome when using topically applied methyl-esterified -aminolevulinic acid (ALA-ME) and -aminolevulinic acid (ALA). A total of 35 pathologically verified BCCs in 14 patients were investigated. A diode laser, emitting continuous light at 633 nm, was used to induce PDT. The diagnostic measurements were performed before, during, and after PDT. Laser-induced fluorescence (LIF) was used to monitor the build-up of the ALA/ALA-ME-induced protoporphyrin IX (PpIX). The superficial tissue perfusion was measured with laser-Doppler perfusion imaging (LDPI) and the temperature of the lesion and the surrounding tissue was imaged with an IR-camera. A clear demarcation between the lesion and the normal skin was detected with LIF before the treatment for both PpIX precursors. The fluorescence measurements suggest that PpIX builds up to a higher degree and more selectively in the tumour following ALA-ME as compared to ALA. The LDPI measurements indicate a local transient restriction in blood perfusion immediately post-PDT. The measurement with the IR-camera revealed a temperature rise of about 1-2°C during the treatment.

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Section: Discussionmentioning

confidence: 99%

Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified δ-aminolevulinic acid

Thompson

Gustafsson

Pålsson

et al. 2001

J. Porphyrins Phthalocyanines

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“…Spectroscopic determinations of the penetration are in reasonable agreement with data obtained by other methods. ALA, being a small hydrophilic molecule, might be expected to penetrate about 3 mm after 3–15 h of topical application 53 . Application times of more than 4 h seem to be necessary for penetration down into thick tumours 37 .…”

Section: Discussionmentioning

confidence: 99%

Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin

Juzeniene

Juzenas

et al. 2006

British Journal of Dermatology

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“…The observations also suggest adequate dosimetry in each group as it has been estimated that only 10% of active photosensitizer remains after an optical dose twice as large as the bleaching fluence. 15 …”

Section: Discussionmentioning

confidence: 99%

Comparison of red and green light in the treatment of Bowen’s disease by photodynamic therapy

Morton

Whitehurst

Moore

et al. 2000

British Journal of Dermatology

141

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Light and drug distribution with topically administered photosensitizers

Cited by 33 publications

References 8 publications

Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified δ-aminolevulinic acid

Photodynamic therapy and diagnostic measurements of basal cell carcinomas using esterified and non-esterified δ-aminolevulinic acid

Topical application of 5-aminolaevulinic acid, methyl 5-aminolaevulinate and hexyl 5-aminolaevulinate on normal human skin

Comparison of red and green light in the treatment of Bowen’s disease by photodynamic therapy

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