Light and electron microscopic observations on rat thyroid after administration of some dithiocarbamates

Ivanova-Chemishanska, L; Markov, D; Dashev, G

doi:10.1016/0013-9351(71)90023-5

Cited by 21 publications

(2 citation statements)

References 12 publications

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“…Animals were fed a synthetic pellet diet toxicity of mancozeb are available, 4-7 information on (Lipton's India Ltd., India) and water ad libitum the anti-hyroidal effects are meagre. 8,9 Our earlier study throughout the period of study. has shown abnormal functional and hyperplastic changes of the thyroid gland in male rats after subacute exposure to mancozeb.…”

Section: Introduction Chemicalsmentioning

confidence: 97%

Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations

1997

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Mancozeb, an ethylenebisdithiocarbamate (EBDC), has been studied for its effects on rat thyroid. Single oral administration of mancozeb at different concentrations (9600, 12 000, 15 000 and 18 750 mg kg−1 body wt) has derived the oral LD50 value as 15 000 mg kg−1 body wt. in male rats. Mancozeb at repeated oral doses of 500, 1000 and 1500 mg kg−1 day−1 for periods of 30, 90, 180 and 360 days has produced dose‐dependent signs of toxicity and death of animals. The fungicide caused a significant increase in thyroid/body weight ratio and histopathological changes. Reduced levels of thyroid radioiodine (125I) uptake, serum protein‐bound iodine (PB125I), thyroxine (T4) and reduced activity of thyroid peroxidase (TPO) have also been observed after exposure to mancozeb. Thus, mancozeb has been shown to produce marked structural and functional changes in thyroid of rats.© 1997 John Wiley & Sons, Ltd. © 1997 by John Wiley & Sons, Ltd.

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Section: Introduction Chemicalsmentioning

confidence: 97%

Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations

1997

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“…Dithiocarbamate fungicides such as mancozeb and thiram and the herbicide pronamide reduce serum concentrations of T 4 and increase thyroid mass in rodents. [34][35][36][37][38][39] Mancozeb decreases TPO activity in vitro, 37 suggesting a mode of action via TH synthesis inhibition. Thyroid hormone synthesis inhibitors also decrease circulating T 3 ; however, these effects occur at higher exposures than those that begin to decrease T 4 .…”

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confidence: 99%

Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine

et al. 2009

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Thyroid hormone (TH) disrupting compounds interfere with both thyroidal and extrathyroidal mechanisms to decrease circulating thyroxine (T(4)). This research tested the hypothesis that serum T(4) concentrations of rodents exposed to a mixture of both TH synthesis inhibitors (pesticides) and stimulators of T(4) clearance in the liver (polyhalogenated aromatic hydrocarbons, PHAHs) could be best predicted by an integrated addition model. Female Long-Evans rats, 23 days of age, were dosed with dilutions of a mixture of 18 PHAHs (2 dioxins, 4 dibenzofurans, and 12 PCBs, including dioxin-like and non-dioxin like PCBs) and a mixture of 3 pesticides (thiram, pronamide, and mancozeb) for four consecutive days. Serum was collected 24 hours after the last exposure and T(4) concentrations were measured by radioimmunoassay. Animals exposed to the highest dose of the mixture experienced a 45% decrease in serum T(4). Three additivity model predictions (dose addition, effect addition, and integrated addition) were generated based on single chemical data, and the results were compared. Effect addition overestimated the effect produced by the combination of all 21 chemicals. The results of the dose- and integrated-addition models were similar, and both provided better predictions than the effect-addition model. These results support the use of dose- and integrated additivity models in predicting the effects of complex mixtures.

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Die Kontrolle der Schilddrüsenfunktion mit Radiojod für die toxikologische Untersuchung von Fremdstoffen

Seidler

Härtig

Lewerenz

1975

Nahrung

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Nach einem kurzen Überblick über den Jod‐ und Hormonstoffwechsel von Schilddrüse und Organismus sowie der Diskussion der Aspekte der Prüfung der Schilddrüsenfunktion wird ein für toxikologische Untersuchungen an der Ratte konzipiertes Prüfungssystem unter Einsatz von 131‐J‐NaJ vorgestellt. Nach einer Beobachtungszeit von 48 h werden in der Schilddrüse J+, J+‐T3, J+‐T4, im Serum J+, J+‐T3, J+‐T4, PBJ+, in der Leber J+, PBJ+ sowie im Urin J+ bestimmt. Aus diesen Meßwerten werden durch Rechenoperationen weitere Aussagen abgeleitet. Die analytischen Arbeiten werden eingehend beschrieben. Die Darstellung der Normalwerte, ihre Veränderung bei modellierten Zustandsänderungen mit bekannter Ursache (J, TSH, MTU) und als Beispiel bei der Prüfung von zwei Wirkstoffen (Maneb, ÄTH) zeigen Aussagewert und Grenzen des Verfahrens. Maneb und noch stärker ÄTH verursachten eine ausgeprägte Hypofunktion.

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Light and electron microscopic observations on rat thyroid after administration of some dithiocarbamates

Cited by 21 publications

References 12 publications

Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations

Studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations

Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine

Die Kontrolle der Schilddrüsenfunktion mit Radiojod für die toxikologische Untersuchung von Fremdstoffen

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