Light and electron microscopic studies of the effect of combined topical calcipotriol and PUVA therapy on patients with vitiligo

Mohamed, Abeer A.K.; EL-Saman, Shereen F.

doi:10.1097/01.ehx.0000394884.67992.01

Cited by 4 publications

(4 citation statements)

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“…As a form of cellular defense mechanism against toxic substances, vacuolation in hepatocytes has been recognized as ballooning degeneration. (13) Apoptosis and necrotic cell death have been associated with cellular degeneration. (14) When amoxicillin/clavulanic acid induces apoptosis, it's accompanied by a rise in oxidative reactive molecules and a fall in antioxidants.…”

Section: Discussionmentioning

confidence: 99%

The Possible Ameliorative Effect of Vitamin C Against Amoxicillin-Clavulanic Acid Toxicity in the liver of Adult Male Albino Rats

Mohammed,

galal,

Mahmoud

et al. 2024

Sohag Medical Journal

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Background: Amoxicillin/clavulanic acid (AC) is used to treat a variety of bacterial infections, most frequently linked to drug-induced hepatotoxicity. Vitamin C is a necessary, water-soluble micronutrient serves as an antioxidant and cofactor for several enzymes, Aim of the work: Our research aimed to study the potential Ameliorative role of vitamin C against the amoxicillin-clavulanic acid induced hepatotoxic effects on the liver of the adult male albino rats. Materials and methods: 03 adult albino rats were used. The animals were equally divided into three groups, each of them consisting of 10 rats. Group I: "control" Animals were not subjected to any treatment. Group II: were given Amoxicillin-Clavulanic Acid. Group III: were given Amoxicillin-Clavulanic Acid and Vitamin C treated it. At the end of the experiment, blood samples and livers were collected for biochemical and histological study. Results: Administration (AC) had apparent hepatotoxic effects in the form of elevations in blood liver enzymes, disruption of the antioxidant capacity of liver tissue. Co-administration of Vitamin C could reduce all the biochemical and histological effects of AC. Conclusion: Vitamin C has protective and therapeutic effects on AC-induced liver damage in rats.

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Section: Discussionmentioning

confidence: 99%

The Possible Ameliorative Effect of Vitamin C Against Amoxicillin-Clavulanic Acid Toxicity in the liver of Adult Male Albino Rats

Mohammed,

galal,

Mahmoud

et al. 2024

Sohag Medical Journal

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“…Cheville (2009) reported that damaged hepatocytes in MSG treated rats is mainly due to they have various surface receptors for toxins and little oxygen. Abdel Hameed, (2004) added that the vacuolation of hepatocytes is considered as a type of cellular defensive mechanism against toxic agents, whereas, these vacuoles can collect the toxic elements and preventing them from disruption of the functional activities of these cells (Cheville, 2009). found that, supplementation of MSG to adult rats was associated with oxidative stress on the liver tissue leading to hepatocellular damage.…”

Section: Discussionmentioning

confidence: 99%

Adverse effects of MSG and aspartame on the liver of Female Albino Rats and their offspring and the possible ameliorative role Opuntia ficus-indica Fruit

Ghanem,

El-beltagy,

Kamel

et al. 2023

Delta University Scientific Journal

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Monosodium glutamate (MSG) and aspartame are the most food addaitives allover-the world. Prolonged xposure to the two additives results in several adverse effects on the differnet body organs. Recently, natural palnts and their fruits are considered as a new medical approach for alleviating of many diseases. In the curunt work we attempt to evaluate the possible ameliorative role of Opuntia ficus-indica Fruit against adverse effects of MSG and aspartame on the liver of mother's rats and their offspring. 36 pregnant rats were used in these studies, they were classified into 6 groups(six for each); control, MSG, aspartame, MSG+ Opuntia ficus-indica Fruit, Aspartame+ Opuntia ficus-indica Fruit and MSG+Aspartame + Opuntia ficus-indica Fruit. At the end of weaning (21 day postnatal), the mothers rats and and their pups were sacrificed, the blood was collected and the whole liver was removed to investigate the histopathological and biochemical changes induced in the liver. The obtained results revealed severe histopathological signs in the liver of MSG and aspartame supplemented mother's rats and their pups, these signs included dilated hepatic sinosoids, dialted central veins, pyknotic hepatocytes and presence of multiple Kupffer cells. Also, remarkable apoptosis appeared in the hepatocytes that indicated by strong expression of P53 and weak expression for Bcl-2. An obvious increase in the liver enzymes (ALT&AST) and caspase-3 but significant decrease in the levels of antioxidants (SOD&CAT) were observed in MSG and aspartame supplemented mother's rats and their pups. Suppelementaion of Opuntia ficusindica Fruit juice was successfully ameliorated the deleterious histopathological and biochemical alterations induced by MSG and aspartame. This amelioration was mainly attributed to the vital phytochemical and antioxidant nutrients in this fruit.

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“…Study conducted by Mohamed and El-Saman [106] on vitiligo patients using light and electron microscopy, showed complete loss of melanin pigment granules in the epidermis, mononuclear cellular infiltration in the dermis, and marked positive ICAM-1 expression over keratinocytes in the epidermis and around endothelial and inflammatory cells in the dermis of the vitiligo sections. The above authors have reported that the biopsies of vitiligous skin samples exhibited significant ultrastructural changes of degenerative nature in the keratinocytes.…”

Section: A Vitiligomentioning

confidence: 96%

Current Challenges in Understanding the Story of Skin Pigmentation — Bridging the Morpho-Anatomical and Functional Aspects of Mammalian Melanocytes

Ali¹,

Naaz²

2015

Muscle Cell and Tissue

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Melanocytes are specialized dendritic melanin producing pigment cells, which have originated from the pluripotent embryonic cells and are termed as neural crest cells NCC . The primary locations of these cells are basal layer of epidermis and hair follicles. "esides this, they are also found in the inner ear, nervous system, and heart with spatial specific functions. There are other cells able to produce melanin but of different embryonic origin pigmented epithelium of retina, some neurons, and adipocytes . Melanocytes of the epidermis and hair are cells which share some common structural features but in general they form biologically different populations living in unique niches of the skin. Ultra structurally, melanocytes differ from each other on the basis of their locations and function. Principal function of epidermal melanocytes is photoprotection and thermoregulation by packaging melanin pigment into melanosomes and delivering them to neighboring keratinocytes. It is unfair to think that melanocytes reap all the glory for their role in pigmenting the skin and providing it critical protection against UV damage. They probably play a significant role in diverse physiological functions and their particular functions in all target places are much wider than the melanin synthesis only. "lternation in any structure and function of these pigmentary cells affects the process of pigmentation/melanogenesis which leads to pigmentary disorders like hyperpigmentation or hypopigmentation.Keywords: Melanocytes, ultrastructure, receptors, pigmentation, disorders © 2015 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. . IntroductionThe biology of skin pigmentation plays a critical role in assorted physiological faculties from lower to higher vertebrates, like social interaction, camouflage, mimicry, sexual display as well as distinct racial coloration as seen in human beings. The pigmented biopolymer referred to as melanin is predominant in contributing color to skin, hair, and eyes of mammals. Melanin destined for pigmentation is produced in melanosomes, which are exclusively synthesized within melanocytes and in retinal pigment epithelial RPE [ ]. Melanocytes are the key components of the pigmentary system because of their ability to produce melanin. These cells are found at many locations throughout the body. Mammalian melanocytes can be classified as cutaneous follicular and epidermal and extracutaneous e.g., choroidal, cochlear [ ]. Though all of them have derived from pluripotent, NCC and have the capacity to synthesize melanin, their distinct task in all target places are much broader than the melanin synthesis solely.The existence of melanocytes is not only restricted to the epidermis but they are also found in other locations of the human body such as hair, iris, part o...

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Light and electron microscopic studies of the effect of combined topical calcipotriol and PUVA therapy on patients with vitiligo

Cited by 4 publications

References 22 publications

The Possible Ameliorative Effect of Vitamin C Against Amoxicillin-Clavulanic Acid Toxicity in the liver of Adult Male Albino Rats

The Possible Ameliorative Effect of Vitamin C Against Amoxicillin-Clavulanic Acid Toxicity in the liver of Adult Male Albino Rats

Adverse effects of MSG and aspartame on the liver of Female Albino Rats and their offspring and the possible ameliorative role Opuntia ficus-indica Fruit

Current Challenges in Understanding the Story of Skin Pigmentation — Bridging the Morpho-Anatomical and Functional Aspects of Mammalian Melanocytes

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